SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4D8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		8 / 11 CYH A 323
ILE A 327
ALA A 330
VAL A 364
ARG A 367
MET A 368
ARG A 370
VAL A 379
 4D8  A 601 ( 4.0A)
None
4D8  A 601 (-3.1A)
None
GOL  A 602 (-4.5A)
4D8  A 601 (-4.0A)
GOL  A 602 (-3.3A)
None
 0.33A 1n4hA-4s15A:
36.7		 1n4hA-4s15A:
59.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		8 / 11 GLN A 289
CYH A 323
ILE A 327
ALA A 330
VAL A 364
MET A 368
ARG A 370
VAL A 379
 4D8  A 601 ( 2.7A)
4D8  A 601 ( 4.0A)
None
4D8  A 601 (-3.1A)
None
4D8  A 601 (-4.0A)
GOL  A 602 (-3.3A)
None
 0.74A 1n4hA-4s15A:
36.7		 1n4hA-4s15A:
59.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		5 / 12 GLN A 289
CYH A 323
ALA A 330
PHE A 391
HIS A 484
 4D8  A 601 ( 2.7A)
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 ( 4.5A)
None
 0.89A 3b0wA-4s15A:
30.1		 3b0wA-4s15A:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		9 / 12 GLN A 289
LEU A 295
CYH A 323
ALA A 330
MET A 368
ALA A 371
VAL A 379
PHE A 391
CYH A 396
 4D8  A 601 ( 2.7A)
None
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 (-4.0A)
4D8  A 601 ( 4.0A)
None
4D8  A 601 ( 4.5A)
4D8  A 601 ( 4.7A)
 0.60A 3b0wA-4s15A:
30.1		 3b0wA-4s15A:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		5 / 12 GLN A 289
CYH A 323
ALA A 330
LEU A 394
HIS A 484
 4D8  A 601 ( 2.7A)
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 ( 4.5A)
None
 0.98A 3b0wB-4s15A:
30.7		 3b0wB-4s15A:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		6 / 12 GLN A 289
LEU A 295
ALA A 330
ALA A 371
VAL A 379
LEU A 394
 4D8  A 601 ( 2.7A)
None
4D8  A 601 (-3.1A)
4D8  A 601 ( 4.0A)
None
4D8  A 601 ( 4.5A)
 1.36A 3b0wB-4s15A:
30.7		 3b0wB-4s15A:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		9 / 12 GLN A 289
LEU A 295
CYH A 323
ALA A 330
MET A 368
ALA A 371
VAL A 379
PHE A 391
LEU A 394
 4D8  A 601 ( 2.7A)
None
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 (-4.0A)
4D8  A 601 ( 4.0A)
None
4D8  A 601 ( 4.5A)
4D8  A 601 ( 4.5A)
 0.46A 3b0wB-4s15A:
30.7		 3b0wB-4s15A:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens) 		7 / 9 LEU A 295
ALA A 330
VAL A 364
ARG A 367
MET A 368
ARG A 370
ALA A 371
 None
4D8  A 601 (-3.1A)
None
GOL  A 602 (-4.5A)
4D8  A 601 (-4.0A)
GOL  A 602 (-3.3A)
4D8  A 601 ( 4.0A)
 0.62A 5g44A-4s15A:
34.9		 5g44A-4s15A:
50.19