SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4CT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 10 VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-2.9A)
 0.47A 1jdvA-3o4vA:
23.4
1jdvD-3o4vA:
23.3		 1jdvA-3o4vA:
26.36
1jdvD-3o4vA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 10 VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 (-2.2A)
 0.39A 1jdvA-5k1zA:
24.1
1jdvD-5k1zA:
24.1		 1jdvA-5k1zA:
23.27
1jdvD-5k1zA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 10 VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-2.9A)
 0.46A 1jdvB-3o4vA:
23.1
1jdvC-3o4vA:
22.9		 1jdvB-3o4vA:
26.36
1jdvC-3o4vA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 10 VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 (-2.2A)
 0.36A 1jdvB-5k1zA:
23.8
1jdvC-5k1zA:
23.3		 1jdvB-5k1zA:
23.27
1jdvC-5k1zA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 10 VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-2.9A)
 0.46A 1jdvA-3o4vA:
23.4
1jdvD-3o4vA:
23.3		 1jdvA-3o4vA:
26.36
1jdvD-3o4vA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 10 VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 (-2.2A)
 0.38A 1jdvA-5k1zA:
24.1
1jdvD-5k1zA:
24.1		 1jdvA-5k1zA:
23.27
1jdvD-5k1zA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		7 / 12 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
4CT  A 233 (-2.9A)
 0.49A 1jdvE-3o4vA:
23.2
1jdvF-3o4vA:
23.0		 1jdvE-3o4vA:
26.36
1jdvF-3o4vA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		7 / 12 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
4CT  A 301 (-2.2A)
 0.44A 1jdvE-5k1zA:
23.9
1jdvF-5k1zA:
23.4		 1jdvE-5k1zA:
23.27
1jdvF-5k1zA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		4 / 8 SER A 197
ASP A 198
GLU A  13
GLU A  12
 4CT  A 301 ( 2.8A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 4.5A)
None
 0.87A 1knyA-5k1zA:
undetectable
1knyB-5k1zA:
undetectable		 1knyA-5k1zA:
23.31
1knyB-5k1zA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		4 / 6 ASN A  73
GLY A  51
ILE A  50
ILE A 178
 None
None
4CT  A 233 (-3.7A)
None
 0.89A 1n49D-3o4vA:
undetectable		 1n49D-3o4vA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.8A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.46A 1odiA-3o4vA:
17.8		 1odiA-3o4vA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 11 GLY A  80
GLU A 173
MET A 174
GLU A 175
SER A 197
 4CT  A 301 (-3.4A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
 0.35A 1odiA-5k1zA:
17.2		 1odiA-5k1zA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.8A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.50A 1odiB-3o4vA:
25.2		 1odiB-3o4vA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 11 GLY A  80
GLU A 173
MET A 174
GLU A 175
SER A 197
 4CT  A 301 (-3.4A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
 0.45A 1odiB-5k1zA:
25.5		 1odiB-5k1zA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.8A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.42A 1odiC-3o4vA:
24.9		 1odiC-3o4vA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 11 GLY A  80
GLU A 173
MET A 174
GLU A 175
SER A 197
 4CT  A 301 (-3.4A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
 0.41A 1odiC-5k1zA:
25.3		 1odiC-5k1zA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.8A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.49A 1odiD-3o4vA:
25.2		 1odiD-3o4vA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 11 GLY A  80
GLU A 173
MET A 174
GLU A 175
SER A 197
 4CT  A 301 (-3.4A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
 0.44A 1odiD-5k1zA:
25.5		 1odiD-5k1zA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.8A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.49A 1odiE-3o4vA:
25.2		 1odiE-3o4vA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 11 GLY A  80
GLU A 173
MET A 174
GLU A 175
SER A 197
 4CT  A 301 (-3.4A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
 0.44A 1odiE-5k1zA:
25.5		 1odiE-5k1zA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.8A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.49A 1odiF-3o4vA:
24.8		 1odiF-3o4vA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 11 GLY A  80
GLU A 173
MET A 174
GLU A 175
SER A 197
 4CT  A 301 (-3.4A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
 0.44A 1odiF-5k1zA:
25.3		 1odiF-5k1zA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		7 / 9 SER A  76
GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
4CT  A 233 (-2.9A)
 0.53A 1pk7A-3o4vA:
23.8		 1pk7A-3o4vA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		6 / 9 GLY A  80
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 4CT  A 301 (-3.4A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
4CT  A 301 (-2.2A)
 0.51A 1pk7A-5k1zA:
23.9		 1pk7A-5k1zA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 8 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.53A 1pk7B-3o4vA:
24.0		 1pk7B-3o4vA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 10 GLY A  79
VAL A 171
GLU A 172
SER A 196
ASP A 197
 None
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.3A)
4CT  A 233 (-2.9A)
 1.44A 1pk7C-3o4vA:
24.8		 1pk7C-3o4vA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		8 / 10 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
4CT  A 233 (-2.9A)
 0.47A 1pk7C-3o4vA:
24.8		 1pk7C-3o4vA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		7 / 10 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
4CT  A 301 (-2.2A)
 0.47A 1pk7C-5k1zA:
24.7		 1pk7C-5k1zA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		8 / 10 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
4CT  A 233 (-2.9A)
 0.43A 1pk9A-3o4vA:
23.7		 1pk9A-3o4vA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		7 / 10 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
4CT  A 301 (-2.2A)
 0.43A 1pk9A-5k1zA:
23.8		 1pk9A-5k1zA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		7 / 9 SER A  76
GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
4CT  A 233 (-2.9A)
 0.44A 1pk9B-3o4vA:
24.0		 1pk9B-3o4vA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		6 / 9 GLY A  80
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 4CT  A 301 (-3.4A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
4CT  A 301 (-2.2A)
 0.43A 1pk9B-5k1zA:
24.0		 1pk9B-5k1zA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		8 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
4CT  A 233 (-2.9A)
 0.37A 1pk9C-3o4vA:
24.7		 1pk9C-3o4vA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		7 / 11 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
4CT  A 301 (-2.2A)
 0.39A 1pk9C-5k1zA:
24.8		 1pk9C-5k1zA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 11 MET A  10
GLY A  80
GLU A 173
SER A 197
ASP A 198
 4CT  A 301 ( 2.9A)
4CT  A 301 (-3.4A)
None
4CT  A 301 ( 2.8A)
4CT  A 301 (-2.2A)
 1.16A 1pk9C-5k1zA:
24.8		 1pk9C-5k1zA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		7 / 10 SER A  76
GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
4CT  A 233 (-2.9A)
 0.51A 1pw7A-3o4vA:
23.8		 1pw7A-3o4vA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		6 / 10 GLY A  80
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 4CT  A 301 (-3.4A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
4CT  A 301 (-2.2A)
 0.48A 1pw7A-5k1zA:
23.9		 1pw7A-5k1zA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 9 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
 0.42A 1pw7B-3o4vA:
24.3		 1pw7B-3o4vA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 9 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
 0.47A 1pw7B-5k1zA:
24.2		 1pw7B-5k1zA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		7 / 9 SER A  76
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
4CT  A 233 (-2.9A)
 0.48A 1pw7C-3o4vA:
24.7		 1pw7C-3o4vA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		6 / 9 VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
4CT  A 301 (-2.2A)
 0.48A 1pw7C-5k1zA:
24.6		 1pw7C-5k1zA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
 0.41A 1vhwA-3o4vA:
24.7
1vhwD-3o4vA:
24.6		 1vhwA-3o4vA:
24.21
1vhwD-3o4vA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 11 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
 0.39A 1vhwA-5k1zA:
24.2
1vhwD-5k1zA:
24.1		 1vhwA-5k1zA:
22.61
1vhwD-5k1zA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 9 SER A  76
GLY A  78
VAL A 171
MET A 173
GLU A 174
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
 0.38A 1vhwB-3o4vA:
24.8
1vhwF-3o4vA:
24.5		 1vhwB-3o4vA:
24.21
1vhwF-3o4vA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
 0.39A 1vhwC-3o4vA:
24.7
1vhwE-3o4vA:
24.7		 1vhwC-3o4vA:
24.21
1vhwE-3o4vA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 11 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
 0.39A 1vhwC-5k1zA:
24.2
1vhwE-5k1zA:
24.3		 1vhwC-5k1zA:
22.61
1vhwE-5k1zA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
 0.39A 1vhwA-3o4vA:
24.7
1vhwD-3o4vA:
24.6		 1vhwA-3o4vA:
24.21
1vhwD-3o4vA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 11 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
 0.39A 1vhwA-5k1zA:
24.2
1vhwD-5k1zA:
24.1		 1vhwA-5k1zA:
22.61
1vhwD-5k1zA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
 0.40A 1vhwC-3o4vA:
24.7
1vhwE-3o4vA:
24.7		 1vhwC-3o4vA:
24.21
1vhwE-3o4vA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 11 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
 0.39A 1vhwC-5k1zA:
24.2
1vhwE-5k1zA:
24.3		 1vhwC-5k1zA:
22.61
1vhwE-5k1zA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 10 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
 0.42A 1vhwB-3o4vA:
24.8
1vhwF-3o4vA:
24.5		 1vhwB-3o4vA:
24.21
1vhwF-3o4vA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 10 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
 0.40A 1vhwB-5k1zA:
24.5
1vhwF-5k1zA:
24.2		 1vhwB-5k1zA:
22.61
1vhwF-5k1zA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 10 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.51A 1z35A-3o4vA:
23.8		 1z35A-3o4vA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		6 / 10 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
 0.52A 1z35A-5k1zA:
23.7		 1z35A-5k1zA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 9 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.42A 1z37A-3o4vA:
23.9		 1z37A-3o4vA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		6 / 9 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
 0.35A 1z37A-5k1zA:
23.7		 1z37A-5k1zA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 11 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-2.9A)
 0.48A 2ac7A-3o4vA:
23.7
2ac7B-3o4vA:
23.7		 2ac7A-3o4vA:
22.22
2ac7B-3o4vA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		6 / 11 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 (-2.2A)
 0.43A 2ac7A-5k1zA:
23.9
2ac7B-5k1zA:
23.9		 2ac7A-5k1zA:
21.95
2ac7B-5k1zA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 11 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-2.9A)
 0.47A 2ac7A-3o4vA:
23.7
2ac7B-3o4vA:
23.7		 2ac7A-3o4vA:
22.22
2ac7B-3o4vA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		6 / 11 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 (-2.2A)
 0.42A 2ac7A-5k1zA:
23.9
2ac7B-5k1zA:
23.9		 2ac7A-5k1zA:
21.95
2ac7B-5k1zA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		4 / 7 MET A  10
ARG A 194
ILE A  14
GLU A  12
 4CT  A 301 ( 2.9A)
4CT  A 301 ( 4.2A)
None
None
 1.47A 2nsiA-5k1zA:
undetectable
2nsiB-5k1zA:
undetectable		 2nsiA-5k1zA:
22.03
2nsiB-5k1zA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		4 / 7 GLU A  12
MET A  10
ARG A 194
ILE A  14
 None
4CT  A 301 ( 2.9A)
4CT  A 301 ( 4.2A)
None
 1.44A 2nsiA-5k1zA:
undetectable
2nsiB-5k1zA:
undetectable		 2nsiA-5k1zA:
22.03
2nsiB-5k1zA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		4 / 7 MET A  10
ARG A 194
ILE A  14
GLU A  12
 4CT  A 301 ( 2.9A)
4CT  A 301 ( 4.2A)
None
None
 1.44A 2nsiC-5k1zA:
undetectable
2nsiD-5k1zA:
undetectable		 2nsiC-5k1zA:
22.03
2nsiD-5k1zA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		4 / 7 GLU A  12
MET A  10
ARG A 194
ILE A  14
 None
4CT  A 301 ( 2.9A)
4CT  A 301 ( 4.2A)
None
 1.45A 2nsiC-5k1zA:
undetectable
2nsiD-5k1zA:
undetectable		 2nsiC-5k1zA:
22.03
2nsiD-5k1zA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		4 / 4 ALA A 168
VAL A 171
PHE A 165
THR A 176
 None
4CT  A 233 ( 4.9A)
None
None
 1.28A 2pkkA-3o4vA:
3.0		 2pkkA-3o4vA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		4 / 7 GLU A 174
ARG A 193
GLU A 172
SER A 147
 4CT  A 233 (-3.0A)
4CT  A 233 ( 4.7A)
None
None
 1.18A 2zt7A-3o4vA:
3.3		 2zt7A-3o4vA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		4 / 7 GLU A 175
ARG A 194
GLU A 173
SER A 149
 4CT  A 301 (-2.2A)
4CT  A 301 ( 4.2A)
None
None
 1.23A 2zt7A-5k1zA:
undetectable		 2zt7A-5k1zA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		4 / 7 MET A  10
ARG A 194
ILE A  14
GLU A  12
 4CT  A 301 ( 2.9A)
4CT  A 301 ( 4.2A)
None
None
 1.47A 3e7gA-5k1zA:
undetectable
3e7gB-5k1zA:
undetectable		 3e7gA-5k1zA:
21.98
3e7gB-5k1zA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		4 / 7 GLU A  12
MET A  10
ARG A 194
ILE A  14
 None
4CT  A 301 ( 2.9A)
4CT  A 301 ( 4.2A)
None
 1.49A 3e7gA-5k1zA:
undetectable
3e7gB-5k1zA:
undetectable		 3e7gA-5k1zA:
21.98
3e7gB-5k1zA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		4 / 7 MET A  10
ARG A 194
ILE A  14
GLU A  12
 4CT  A 301 ( 2.9A)
4CT  A 301 ( 4.2A)
None
None
 1.41A 3e7gC-5k1zA:
undetectable
3e7gD-5k1zA:
undetectable		 3e7gC-5k1zA:
21.98
3e7gD-5k1zA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 GLY A  51
THR A 176
ALA A   8
GLU A  12
ALA A 150
 None
None
4CT  A 233 ( 3.7A)
4CT  A 233 ( 4.0A)
GOL  A 235 (-4.0A)
 1.04A 3g89A-3o4vA:
undetectable		 3g89A-3o4vA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 11 GLY A  51
THR A 176
ALA A   8
GLU A  12
ALA A 150
 None
None
4CT  A 233 ( 3.7A)
4CT  A 233 ( 4.0A)
GOL  A 235 (-4.0A)
 1.03A 3g89B-3o4vA:
undetectable		 3g89B-3o4vA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 GLY A  51
THR A 176
ALA A   8
GLU A  12
ALA A 150
 None
None
4CT  A 233 ( 3.7A)
4CT  A 233 ( 4.0A)
GOL  A 235 (-4.0A)
 1.09A 3g8bA-3o4vA:
undetectable		 3g8bA-3o4vA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 GLY A  51
THR A 176
ALA A   8
GLU A  12
ALA A 150
 None
None
4CT  A 233 ( 3.7A)
4CT  A 233 ( 4.0A)
GOL  A 235 (-4.0A)
 1.07A 3g8bB-3o4vA:
undetectable		 3g8bB-3o4vA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 12 GLY A   8
ILE A  14
LEU A 212
GLU A 173
VAL A  78
 None
None
None
None
4CT  A 301 (-4.1A)
 1.06A 3o7wA-5k1zA:
undetectable		 3o7wA-5k1zA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		4 / 5 ASP A 198
SER A 197
VAL A  78
GLY A  80
 4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
4CT  A 301 (-4.1A)
4CT  A 301 (-3.4A)
 0.95A 3rxhA-5k1zA:
undetectable		 3rxhA-5k1zA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_A_ADNA251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 9 SER A  76
VAL A 171
GLU A 172
MET A 173
GLU A 174
 4CT  A 233 (-3.2A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
 0.50A 3u40A-3o4vA:
23.9
3u40F-3o4vA:
23.3		 3u40A-3o4vA:
26.46
3u40F-3o4vA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_B_ADNB251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 10 SER A  76
VAL A 171
GLU A 172
MET A 173
GLU A 174
 4CT  A 233 (-3.2A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
 0.44A 3u40B-3o4vA:
23.9
3u40C-3o4vA:
23.9		 3u40B-3o4vA:
26.46
3u40C-3o4vA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		7 / 12 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-2.9A)
 0.41A 3u40B-3o4vA:
23.9
3u40C-3o4vA:
23.9		 3u40B-3o4vA:
26.46
3u40C-3o4vA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		6 / 12 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 (-2.2A)
 0.30A 3u40B-5k1zA:
24.0
3u40C-5k1zA:
23.8		 3u40B-5k1zA:
27.44
3u40C-5k1zA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		7 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-2.9A)
 0.40A 3u40D-3o4vA:
24.2
3u40E-3o4vA:
23.7		 3u40D-3o4vA:
26.46
3u40E-3o4vA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		6 / 11 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 (-2.2A)
 0.33A 3u40D-5k1zA:
24.2
3u40E-5k1zA:
23.8		 3u40D-5k1zA:
27.44
3u40E-5k1zA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		7 / 12 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-2.9A)
 0.38A 3u40D-3o4vA:
24.2
3u40E-3o4vA:
23.7		 3u40D-3o4vA:
26.46
3u40E-3o4vA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		6 / 12 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 (-2.2A)
 0.31A 3u40D-5k1zA:
24.2
3u40E-5k1zA:
23.8		 3u40D-5k1zA:
27.44
3u40E-5k1zA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_F_ADNF251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 10 SER A  76
VAL A 171
GLU A 172
MET A 173
GLU A 174
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-2.9A)
 0.72A 3u40A-3o4vA:
23.9
3u40F-3o4vA:
23.3		 3u40A-3o4vA:
26.46
3u40F-3o4vA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_F_ADNF251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 10 VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 (-2.2A)
 0.60A 3u40A-5k1zA:
23.9
3u40F-5k1zA:
23.5		 3u40A-5k1zA:
27.44
3u40F-5k1zA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		7 / 11 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
ASP A 197
 4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
4CT  A 233 (-2.9A)
 0.45A 3uawA-3o4vA:
24.2		 3uawA-3o4vA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		7 / 11 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
4CT  A 301 (-2.2A)
 0.38A 3uawA-5k1zA:
24.6		 3uawA-5k1zA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 10 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
 0.47A 3uayA-3o4vA:
23.9		 3uayA-3o4vA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 10 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
 0.42A 3uayA-5k1zA:
24.5		 3uayA-5k1zA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 12 LEU A 212
GLY A  77
ILE A  14
PHE A  75
ALA A  79
 None
None
None
None
4CT  A 301 (-4.5A)
 1.15A 4a6dA-5k1zA:
undetectable		 4a6dA-5k1zA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 11 PHE A 208
ASN A 199
GLY A 205
ALA A 216
MET A  10
 4CT  A 301 (-3.5A)
None
None
None
4CT  A 301 ( 2.9A)
 1.34A 4a6nA-5k1zA:
undetectable		 4a6nA-5k1zA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 10 GLY A   7
GLU A 174
GLY A  75
SER A  76
PHE A 207
 None
4CT  A 233 (-3.0A)
None
4CT  A 233 (-3.2A)
4CT  A 233 (-4.5A)
 0.81A 4bwlC-3o4vA:
undetectable		 4bwlC-3o4vA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		7 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.47A 4d9hA-3o4vA:
24.1		 4d9hA-3o4vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 11 SER A  76
GLY A  78
VAL A 171
SER A 196
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
4CT  A 233 (-3.3A)
4CT  A 233 (-2.9A)
 0.77A 4d9hA-3o4vA:
24.1		 4d9hA-3o4vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		6 / 11 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
 0.36A 4d9hA-5k1zA:
25.0		 4d9hA-5k1zA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 11 GLY A  80
VAL A 172
MET A 174
SER A 197
ASP A 198
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
4CT  A 301 (-3.0A)
4CT  A 301 ( 2.8A)
4CT  A 301 (-2.2A)
 0.75A 4d9hA-5k1zA:
25.0		 4d9hA-5k1zA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 9 SER A  76
GLY A  78
VAL A 171
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.63A 4da6A-3o4vA:
23.7		 4da6A-3o4vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 9 SER A  76
GLY A  78
VAL A 171
SER A 196
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
4CT  A 233 (-3.3A)
4CT  A 233 (-2.9A)
 0.94A 4da6A-3o4vA:
23.7		 4da6A-3o4vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 9 GLY A  80
VAL A 172
MET A 174
GLU A 175
SER A 197
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
 0.61A 4da6A-5k1zA:
24.6		 4da6A-5k1zA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 9 GLY A  80
VAL A 172
MET A 174
SER A 197
ASP A 198
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
4CT  A 301 (-3.0A)
4CT  A 301 ( 2.8A)
4CT  A 301 (-2.2A)
 0.90A 4da6A-5k1zA:
24.6		 4da6A-5k1zA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 10 GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.47A 4da7A-3o4vA:
24.2		 4da7A-3o4vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		6 / 10 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
 0.43A 4da7A-5k1zA:
25.0		 4da7A-5k1zA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		7 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.51A 4danA-3o4vA:
23.7		 4danA-3o4vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 11 SER A  76
GLY A  78
VAL A 171
MET A 173
SER A 196
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
4CT  A 233 (-3.6A)
4CT  A 233 (-3.3A)
4CT  A 233 (-2.9A)
 0.83A 4danA-3o4vA:
23.7		 4danA-3o4vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		7 / 11 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
4CT  A 301 (-2.2A)
 0.67A 4danA-5k1zA:
24.6		 4danA-5k1zA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		7 / 12 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.52A 4danA-3o4vA:
23.7
4danB-3o4vA:
23.9		 4danA-3o4vA:
20.73
4danB-3o4vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		7 / 12 SER A  76
GLY A  78
VAL A 171
MET A 173
GLU A 174
SER A 196
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
4CT  A 233 (-2.9A)
 0.76A 4danA-3o4vA:
23.7
4danB-3o4vA:
23.9		 4danA-3o4vA:
20.73
4danB-3o4vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		7 / 12 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
4CT  A 301 (-2.2A)
 0.67A 4danA-5k1zA:
24.6
4danB-5k1zA:
24.7		 4danA-5k1zA:
20.99
4danB-5k1zA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		4 / 6 GLU A 174
ARG A 193
GLU A 172
SER A 147
 4CT  A 233 (-3.0A)
4CT  A 233 ( 4.7A)
None
None
 1.20A 4kr3A-3o4vA:
undetectable		 4kr3A-3o4vA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		4 / 6 GLU A 175
ARG A 194
GLU A 173
SER A 149
 4CT  A 301 (-2.2A)
4CT  A 301 ( 4.2A)
None
None
 1.13A 4kr3A-5k1zA:
undetectable		 4kr3A-5k1zA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		4 / 7 VAL A 146
ILE A 161
ILE A 152
ALA A 199
 None
None
GOL  A 235 (-4.1A)
4CT  A 233 ( 4.1A)
 0.89A 4lv9A-3o4vA:
undetectable		 4lv9A-3o4vA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		4 / 7 VAL A 146
ILE A 161
ILE A 152
ALA A 199
 None
None
GOL  A 235 (-4.1A)
4CT  A 233 ( 4.1A)
 0.93A 4lv9B-3o4vA:
undetectable		 4lv9B-3o4vA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		4 / 5 GLU A 174
ALA A 175
GLU A 172
GLU A  12
 4CT  A 233 (-3.0A)
None
None
4CT  A 233 ( 4.0A)
 1.49A 5dwkC-3o4vA:
undetectable		 5dwkC-3o4vA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 9 SER A  76
GLY A  78
VAL A 171
MET A 173
GLU A 174
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
 0.35A 5i3cA-3o4vA:
24.3		 5i3cA-3o4vA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		6 / 10 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
 0.39A 5i3cB-3o4vA:
24.8		 5i3cB-3o4vA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		5 / 10 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
 0.44A 5i3cB-5k1zA:
24.4		 5i3cB-5k1zA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		7 / 11 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-3.0A)
4CT  A 233 (-3.3A)
 0.44A 5i3cC-3o4vA:
24.3		 5i3cC-3o4vA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE
(Helicobacter
pylori) 		6 / 11 GLY A  80
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
 4CT  A 301 (-3.4A)
4CT  A 301 ( 4.5A)
None
4CT  A 301 (-3.0A)
4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
 0.45A 5i3cC-5k1zA:
24.0		 5i3cC-5k1zA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 ALA A  55
MET A   9
ILE A  50
GLY A  75
ILE A 178
 None
4CT  A 233 ( 3.8A)
4CT  A 233 (-3.7A)
None
None
 1.12A 5m24A-3o4vA:
undetectable		 5m24A-3o4vA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 12 VAL A  13
GLU A  12
THR A  60
ARG A 193
GLY A  51
 None
4CT  A 233 ( 4.0A)
None
4CT  A 233 ( 4.7A)
None
 1.34A 5m50B-3o4vA:
3.6		 5m50B-3o4vA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 9 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
 0.35A 5zncA-3o4vA:
23.6		 5zncA-3o4vA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		5 / 9 SER A  76
VAL A 171
GLU A 172
MET A 173
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-2.9A)
 1.03A 5zncA-3o4vA:
23.6		 5zncA-3o4vA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		4 / 4 VAL A 171
GLY A  78
ASP A 197
ASP A 200
 4CT  A 233 ( 4.9A)
4CT  A 233 (-3.8A)
4CT  A 233 (-2.9A)
None
 1.32A 6cjkC-3o4vA:
undetectable		 6cjkC-3o4vA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 3o4v MTA/SAH NUCLEOSIDASE
(Escherichia
coli) 		3 / 3 SER A 219
SER A 218
ALA A   8
 None
None
4CT  A 233 ( 3.7A)
 0.68A 6dwnC-3o4vA:
undetectable		 6dwnC-3o4vA:
14.89