SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4AD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		4 / 8 TYR A 240
ARG A 227
TYR A 226
THR A 177
 4AD  A 500 ( 3.5A)
4AD  A 500 (-3.1A)
None
None
 1.40A 1ceaA-3m4pA:
undetectable
1ceaB-3m4pA:
undetectable		 1ceaA-3m4pA:
12.44
1ceaB-3m4pA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		5 / 12 ARG A 227
GLU A 246
TYR A 351
GLY A 378
GLY A 418
 4AD  A 500 (-3.1A)
None
None
4AD  A 500 ( 4.3A)
None
 1.00A 1httB-3m4pA:
15.1		 1httB-3m4pA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		5 / 12 ARG A 227
GLU A 246
TYR A 351
GLY A 378
GLY A 418
 4AD  A 500 (-3.1A)
None
None
4AD  A 500 ( 4.3A)
None
 1.06A 1httD-3m4pA:
15.1		 1httD-3m4pA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		3 / 3 LEU A 237
LEU A 223
MET A 222
 4AD  A 500 (-4.4A)
None
None
 0.87A 2itzA-3m4pA:
undetectable		 2itzA-3m4pA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		3 / 3 ILE A 341
MET A 352
ARG A 381
 None
None
4AD  A 500 (-3.3A)
 0.87A 4lnwA-3m4pA:
undetectable		 4lnwA-3m4pA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		3 / 3 ILE A 341
MET A 352
ARG A 381
 None
None
4AD  A 500 (-3.3A)
 0.88A 4lnxA-3m4pA:
undetectable		 4lnxA-3m4pA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		6 / 10 ARG A 227
GLU A 229
HIS A 236
GLY A 422
ARG A 425
ILE A 436
 4AD  A 500 (-3.1A)
4AD  A 500 (-4.2A)
4AD  A 500 (-4.5A)
4AD  A 500 (-3.7A)
4AD  A 500 (-3.8A)
None
 0.65A 6bniA-3m4pA:
30.2		 6bniA-3m4pA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		6 / 10 GLU A 229
HIS A 236
GLU A 374
GLY A 422
ARG A 425
ILE A 436
 4AD  A 500 (-4.2A)
4AD  A 500 (-4.5A)
4AD  A 500 (-4.1A)
4AD  A 500 (-3.7A)
4AD  A 500 (-3.8A)
None
 0.81A 6bniA-3m4pA:
30.2		 6bniA-3m4pA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		6 / 10 ARG A 227
GLU A 229
HIS A 236
GLY A 422
ARG A 425
ILE A 436
 4AD  A 500 (-3.1A)
4AD  A 500 (-4.2A)
4AD  A 500 (-4.5A)
4AD  A 500 (-3.7A)
4AD  A 500 (-3.8A)
None
 0.63A 6bniB-3m4pA:
30.2		 6bniB-3m4pA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE
(Entamoeba
histolytica) 		6 / 10 GLU A 229
HIS A 236
GLU A 374
GLY A 422
ARG A 425
ILE A 436
 4AD  A 500 (-4.2A)
4AD  A 500 (-4.5A)
4AD  A 500 (-4.1A)
4AD  A 500 (-3.7A)
4AD  A 500 (-3.8A)
None
 0.79A 6bniB-3m4pA:
30.2		 6bniB-3m4pA:
10.20