SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4A2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		5 / 9 ILE A  19
LEU A 316
VAL A 298
GLY A 296
LEU A 324
 None
None
None
4A2  A1366 (-3.4A)
None
 1.26A 1e7aB-3zcwA:
undetectable		 1e7aB-3zcwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		5 / 12 VAL A 264
LEU A 160
SER A 159
ILE A 163
LEU A 168
 None
4A2  A1367 (-4.9A)
None
None
None
 1.16A 3w68A-3zcwA:
undetectable		 3w68A-3zcwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 5 LEU A 295
GLY A 296
ILE A 332
LYS A  18
 4A2  A1366 (-4.1A)
4A2  A1366 (-3.4A)
4A2  A1366 (-3.9A)
None
 1.00A 4ma8C-3zcwA:
undetectable		 4ma8C-3zcwA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		5 / 12 ILE A 196
THR A 100
SER A 240
LEU A 295
LEU A 316
 None
None
None
4A2  A1366 (-4.1A)
None
 1.15A 4qztA-3zcwA:
undetectable		 4qztA-3zcwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 8 ILE A  19
LEU A 320
ILE A 332
THR A 328
 None
None
4A2  A1366 (-3.9A)
None
 0.66A 5uihA-3zcwA:
undetectable		 5uihA-3zcwA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 7 GLY A 217
ILE A 136
GLN A  78
TRP A 127
 4A2  A1367 (-3.3A)
4A2  A1367 (-3.4A)
None
None
 0.83A 5vlmC-3zcwA:
undetectable		 5vlmC-3zcwA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 3zcw KINESIN-LIKE PROTEIN
KIF11
(Homo
sapiens) 		4 / 8 GLY A 217
ILE A 136
GLN A  78
TRP A 127
 4A2  A1367 (-3.3A)
4A2  A1367 (-3.4A)
None
None
 0.89A 5vlmD-3zcwA:
undetectable		 5vlmD-3zcwA:
19.55