SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '49S'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MMD_A_29EA603_1 (TRANSPORTER)	4y9v	PARTICLE-ASSOCIATED LYASE (Acinetobacter virus AP22)	5 / 10	VAL A 404 ALA A 405 GLY A 420 SER A 385 GLY A 407	None None None None 49S A 814 (-3.5A)	1.22A	4mmdA-4y9vA: undetectable	4mmdA-4y9vA: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MMD_B_29EB603_1 (TRANSPORTER)	4y9v	PARTICLE-ASSOCIATED LYASE (Acinetobacter virus AP22)	5 / 12	VAL A 404 ALA A 405 GLY A 420 SER A 385 GLY A 407	None None None None 49S A 814 (-3.5A)	1.19A	4mmdB-4y9vA: undetectable	4mmdB-4y9vA: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N48_B_SAMB601_1 (CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-M ETHYLTRANSFERASE 1)	4y9v	PARTICLE-ASSOCIATED LYASE (Acinetobacter virus AP22)	4 / 5	ASN A 441 GLY A 407 ASP A 448 ASP A 437	49S A 814 (-3.6A) 49S A 814 (-3.5A) None SO4 A 809 ( 4.7A)	1.15A	4n48B-4y9vA: undetectable	4n48B-4y9vA: 22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N49_A_SAMA601_1 (CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-M ETHYLTRANSFERASE 1)	4y9v	PARTICLE-ASSOCIATED LYASE (Acinetobacter virus AP22)	4 / 4	ASN A 441 GLY A 407 ASP A 448 ASP A 437	49S A 814 (-3.6A) 49S A 814 (-3.5A) None SO4 A 809 ( 4.7A)	1.12A	4n49A-4y9vA: undetectable	4n49A-4y9vA: 22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OEX_A_CUA601_0 (THIOCYANATE DEHYDROGENASE)	4y9v	PARTICLE-ASSOCIATED LYASE (Acinetobacter virus AP22)	3 / 3	HIS A 439 ASP A 437 HIS A 402	49S A 814 ( 3.4A) SO4 A 809 ( 4.7A) SO4 A 809 (-3.9A)	0.71A	5oexA-4y9vA: undetectable	5oexA-4y9vA: 21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OEX_B_CUB601_0 (THIOCYANATE DEHYDROGENASE)	4y9v	PARTICLE-ASSOCIATED LYASE (Acinetobacter virus AP22)	3 / 3	HIS A 439 ASP A 437 HIS A 402	49S A 814 ( 3.4A) SO4 A 809 ( 4.7A) SO4 A 809 (-3.9A)	0.74A	5oexB-4y9vA: undetectable	5oexB-4y9vA: 21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OEX_D_CUD601_0 (THIOCYANATE DEHYDROGENASE)	4y9v	PARTICLE-ASSOCIATED LYASE (Acinetobacter virus AP22)	3 / 3	HIS A 439 ASP A 437 HIS A 402	49S A 814 ( 3.4A) SO4 A 809 ( 4.7A) SO4 A 809 (-3.9A)	0.76A	5oexD-4y9vA: undetectable	5oexD-4y9vA: 21.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4MMD_A_29EA603_1","TRANSPORTER","4y9v","PARTICLE-ASSOCIATED LYASE","Acinetobacter virus AP22",5,"VAL A 404;ALA A 405;GLY A 420;SER A 385;GLY A 407","None;None;None;None;49S A 814 (-3.5A)","1.22A","4mmdA-4y9vA:undetectable",null],["4MMD_B_29EB603_1","TRANSPORTER","4y9v","PARTICLE-ASSOCIATED LYASE","Acinetobacter virus AP22",5,"VAL A 404;ALA A 405;GLY A 420;SER A 385;GLY A 407","None;None;None;None;49S A 814 (-3.5A)","1.19A","4mmdB-4y9vA:undetectable","4mmdA-4y9vA:20.38"],["4N48_B_SAMB601_1","CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1","4y9v","PARTICLE-ASSOCIATED LYASE","Acinetobacter virus AP22",4,"ASN A 441;GLY A 407;ASP A 448;ASP A 437","49S A 814 (-3.6A);49S A 814 (-3.5A);None;SO4 A 809 ( 4.7A)","1.15A","4n48B-4y9vA:undetectable","4mmdB-4y9vA:20.38"],["4N49_A_SAMA601_1","CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1","4y9v","PARTICLE-ASSOCIATED LYASE","Acinetobacter virus AP22",4,"ASN A 441;GLY A 407;ASP A 448;ASP A 437","49S A 814 (-3.6A);49S A 814 (-3.5A);None;SO4 A 809 ( 4.7A)","1.12A","4n49A-4y9vA:undetectable","4n48B-4y9vA:22.60"],["5OEX_A_CUA601_0","THIOCYANATE DEHYDROGENASE","4y9v","PARTICLE-ASSOCIATED LYASE","Acinetobacter virus AP22",3,"HIS A 439;ASP A 437;HIS A 402","49S A 814 ( 3.4A);SO4 A 809 ( 4.7A);SO4 A 809 (-3.9A)","0.71A","5oexA-4y9vA:undetectable","4n49A-4y9vA:22.60"],["5OEX_B_CUB601_0","THIOCYANATE DEHYDROGENASE","4y9v","PARTICLE-ASSOCIATED LYASE","Acinetobacter virus AP22",3,"HIS A 439;ASP A 437;HIS A 402","49S A 814 ( 3.4A);SO4 A 809 ( 4.7A);SO4 A 809 (-3.9A)","0.74A","5oexB-4y9vA:undetectable","5oexA-4y9vA:21.36"],["5OEX_D_CUD601_0","THIOCYANATE DEHYDROGENASE","4y9v","PARTICLE-ASSOCIATED LYASE","Acinetobacter virus AP22",3,"HIS A 439;ASP A 437;HIS A 402","49S A 814 ( 3.4A);SO4 A 809 ( 4.7A);SO4 A 809 (-3.9A)","0.76A","5oexD-4y9vA:undetectable","5oexB-4y9vA:21.36"]]