SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '48H'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 7 THR A 129
LEU A  58
GLY A  36
LEU A  42
 None
None
48H  A 302 (-3.2A)
None
 0.74A 1gtiA-4y4nA:
undetectable		 1gtiA-4y4nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 7 THR A 129
LEU A  58
GLY A  36
LEU A  42
 None
None
48H  A 302 (-3.2A)
None
 0.84A 1gtiB-4y4nA:
undetectable		 1gtiB-4y4nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 7 THR A 129
LEU A  58
GLY A  36
LEU A  42
 None
None
48H  A 302 (-3.2A)
None
 0.98A 1gtiD-4y4nA:
undetectable		 1gtiD-4y4nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 7 THR A 129
LEU A  58
GLY A  36
LEU A  42
 None
None
48H  A 302 (-3.2A)
None
 0.73A 1gtiE-4y4nA:
undetectable		 1gtiE-4y4nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 5 PRO A  39
ILE A 240
GLY A 242
TYR A 245
 48H  A 302 (-3.4A)
None
None
None
 1.12A 2jkjD-4y4nA:
undetectable		 2jkjD-4y4nA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		4 / 5 PRO A  39
ILE A 240
GLY A 242
TYR A 245
 48H  A 302 (-3.4A)
None
None
None
 1.12A 2jkjF-4y4nA:
undetectable		 2jkjF-4y4nA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 VAL A  35
ALA A  44
ALA A  45
ALA A 252
VAL A 146
 48H  A 302 (-4.9A)
None
None
None
None
 0.86A 3fc6C-4y4nA:
undetectable		 3fc6C-4y4nA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 THR A 214
GLY A 225
GLY A 243
ASP A 172
GLU A 216
 None
48H  A 302 (-3.5A)
None
None
None
 1.38A 3tkaA-4y4nA:
2.5		 3tkaA-4y4nA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 ILE A  27
GLY A  36
VAL A 146
ILE A 148
VAL A 133
 None
48H  A 302 (-3.2A)
None
None
48H  A 302 (-4.2A)
 1.02A 4c9lA-4y4nA:
undetectable		 4c9lA-4y4nA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 ILE A  27
GLY A  36
VAL A 146
ILE A 148
VAL A 133
 None
48H  A 302 (-3.2A)
None
None
48H  A 302 (-4.2A)
 1.05A 4c9lB-4y4nA:
undetectable		 4c9lB-4y4nA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 ILE A  27
GLY A  36
VAL A 146
ILE A 148
VAL A 133
 None
48H  A 302 (-3.2A)
None
None
48H  A 302 (-4.2A)
 1.00A 4c9oA-4y4nA:
undetectable		 4c9oA-4y4nA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 ILE A  27
GLY A  36
VAL A 146
ILE A 148
VAL A 133
 None
48H  A 302 (-3.2A)
None
None
48H  A 302 (-4.2A)
 1.00A 4c9oB-4y4nA:
undetectable		 4c9oB-4y4nA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 GLY A  65
GLY A  66
GLY A  67
SER A 109
ALA A 117
 None
48H  A 302 (-2.8A)
48H  A 302 (-3.8A)
None
None
 0.97A 4htfA-4y4nA:
2.7		 4htfA-4y4nA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 12 GLU A  81
GLY A 242
GLY A 243
ASN A 229
GLY A 225
 None
None
None
None
48H  A 302 (-3.5A)
 1.16A 6gneB-4y4nA:
3.7		 6gneB-4y4nA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Methanotorris
igneus) 		5 / 9 ILE A 165
ILE A  28
GLU A  59
VAL A  56
ILE A  27
 None
None
48H  A 302 (-2.7A)
None
None
 1.34A 6hloA-4y4nA:
3.2		 6hloA-4y4nA:
20.57