SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '482'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		4 / 5 THR A 234
GLU A 385
THR A 386
HIS A 342
 None
NAP  A 482 (-3.5A)
None
None
 1.16A 1d4fA-3jz4A:
2.1		 1d4fA-3jz4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		4 / 5 THR A 234
GLU A 385
THR A 386
HIS A 342
 None
NAP  A 482 (-3.5A)
None
None
 1.21A 1d4fC-3jz4A:
4.0		 1d4fC-3jz4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 5 HIS A  76
HIS A 158
HIS A 396
HIS A 418
ASP A  75
 ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
ZN  A 481 ( 3.4A)
ZN  A 481 ( 2.6A)
 1.20A 1e9yB-2i7tA:
undetectable		 1e9yB-2i7tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 6 HIS A  76
HIS A 158
HIS A 396
HIS A 418
ASP A  75
 ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
ZN  A 481 ( 3.4A)
ZN  A 481 ( 2.6A)
 1.18A 1fweC-2i7tA:
undetectable		 1fweC-2i7tA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3qom 6-PHOSPHO-BETA-GLUCO
SIDASE
(Lactobacillus
plantarum) 		5 / 10 GLY A  26
HIS A  64
THR A  95
SER A  35
ALA A  37
 None
PO4  A 482 (-3.7A)
None
None
None
 1.48A 1gtnO-3qomA:
undetectable
1gtnP-3qomA:
undetectable		 1gtnO-3qomA:
11.23
1gtnP-3qomA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 5c05 PUTATIVE
GAMMA-TERPINENE
SYNTHASE
(Thymus
vulgaris) 		4 / 8 LEU A 562
LEU A 482
TYR A 478
SER A 416
 LEU  A 562 ( 0.6A)
LEU  A 482 ( 0.5A)
TYR  A 478 ( 1.3A)
SER  A 416 ( 0.0A)
 1.20A 1hk2A-5c05A:
2.2		 1hk2A-5c05A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		5 / 11 GLY A 418
SER A 373
GLY A 450
ASP A 259
ILE A 277
 JW5  A 482 ( 4.9A)
None
JW5  A 482 (-3.4A)
JW5  A 482 (-2.9A)
None
 1.24A 1jzsA-2qcmA:
undetectable		 1jzsA-2qcmA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 10 ALA A 322
GLY A  44
GLY A  45
PRO A  54
THR A  55
 FAD  A8482 (-3.4A)
None
FAD  A8482 (-3.0A)
None
FAD  A8482 (-4.3A)
 1.10A 1k6cA-2eq9A:
undetectable		 1k6cA-2eq9A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 11 GLU A 248
HIS A 158
HIS A 396
ALA A 395
PHE A 393
 None
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
None
None
 1.32A 1mjqA-2i7tA:
undetectable
1mjqB-2i7tA:
undetectable		 1mjqA-2i7tA:
12.28
1mjqB-2i7tA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 11 GLU A 248
HIS A 158
HIS A 396
ALA A 395
PHE A 393
 None
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
None
None
 1.34A 1mjqI-2i7tA:
undetectable
1mjqJ-2i7tA:
undetectable		 1mjqI-2i7tA:
12.28
1mjqJ-2i7tA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		5 / 12 GLY A 238
HIS A 242
SER A 216
PHE A 266
VAL A 267
 AMP  A 482 ( 3.9A)
AMP  A 482 (-4.2A)
None
None
None
 1.44A 1qu3A-3sp1A:
14.6		 1qu3A-3sp1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		3 / 3 ILE A 446
ILE A 448
THR A 252
 None
JW5  A 482 ( 4.6A)
None
 0.61A 1rg7A-2qcmA:
undetectable		 1rg7A-2qcmA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 6 GLY P 363
ILE P 344
GLN P 362
SER P 307
 CA  P 482 (-4.4A)
None
None
None
 0.93A 1rs7B-3hbuP:
undetectable		 1rs7B-3hbuP:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		4 / 6 GLY P 364
ILE P 344
GLN P 362
SER P 307
 CA  P 482 (-4.2A)
None
None
None
 1.05A 1rs7B-3hbuP:
undetectable		 1rs7B-3hbuP:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.46A 1v54A-3sp1A:
undetectable
1v54C-3sp1A:
undetectable		 1v54A-3sp1A:
20.43
1v54C-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.44A 1v54N-3sp1A:
undetectable
1v54P-3sp1A:
undetectable		 1v54N-3sp1A:
20.43
1v54P-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.47A 1v55A-3sp1A:
undetectable
1v55C-3sp1A:
undetectable		 1v55A-3sp1A:
20.43
1v55C-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR
(Yersinia
enterocolitica) 		5 / 12 TYR A 110
THR A 111
TYR A  50
SER A  32
VAL A  69
 None
None
482  A 201 (-4.5A)
482  A 201 (-2.8A)
482  A 201 (-4.6A)
 1.26A 1z9hA-5l09A:
undetectable		 1z9hA-5l09A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR
(Yersinia
enterocolitica) 		5 / 12 TYR A 110
THR A 111
TYR A  50
SER A  32
VAL A  69
 None
None
482  A 201 (-4.5A)
482  A 201 (-2.8A)
482  A 201 (-4.6A)
 1.27A 1z9hB-5l09A:
undetectable		 1z9hB-5l09A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR
(Yersinia
enterocolitica) 		5 / 12 TYR A 110
THR A 111
TYR A  50
SER A  32
VAL A  69
 None
None
482  A 201 (-4.5A)
482  A 201 (-2.8A)
482  A 201 (-4.6A)
 1.26A 1z9hC-5l09A:
undetectable		 1z9hC-5l09A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		4 / 6 LEU A 254
TYR A 466
ILE A 453
GLY A 418
 None
None
None
JW5  A 482 ( 4.9A)
 0.81A 2du8A-2qcmA:
undetectable		 2du8A-2qcmA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		4 / 6 LEU A 254
TYR A 466
ILE A 453
GLY A 418
 None
None
None
JW5  A 482 ( 4.9A)
 0.84A 2du8B-2qcmA:
undetectable		 2du8B-2qcmA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.46A 2dyrA-3sp1A:
undetectable
2dyrC-3sp1A:
undetectable		 2dyrA-3sp1A:
20.43
2dyrC-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.46A 2dyrN-3sp1A:
0.2
2dyrP-3sp1A:
undetectable		 2dyrN-3sp1A:
20.43
2dyrP-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 6 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.46A 2dysA-3sp1A:
undetectable
2dysC-3sp1A:
undetectable		 2dysA-3sp1A:
20.43
2dysC-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 6 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.44A 2dysN-3sp1A:
undetectable
2dysP-3sp1A:
undetectable		 2dysN-3sp1A:
20.43
2dysP-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 12 GLU A 235
ILE A 152
LEU A 228
GLY A 237
ILE A 236
 None
NAP  A 482 ( 4.2A)
None
None
NAP  A 482 (-3.6A)
 0.93A 2e7fA-3jz4A:
undetectable		 2e7fA-3jz4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 12 GLU A 235
ILE A 152
LEU A 228
GLY A 237
ILE A 236
 None
NAP  A 482 ( 4.2A)
None
None
NAP  A 482 (-3.6A)
 0.98A 2e7fB-3jz4A:
undetectable		 2e7fB-3jz4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.46A 2eijA-3sp1A:
undetectable
2eijC-3sp1A:
undetectable		 2eijA-3sp1A:
20.43
2eijC-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.45A 2eijN-3sp1A:
undetectable
2eijP-3sp1A:
undetectable		 2eijN-3sp1A:
20.43
2eijP-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.46A 2eikA-3sp1A:
undetectable
2eikC-3sp1A:
undetectable		 2eikA-3sp1A:
20.43
2eikC-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.45A 2eikN-3sp1A:
undetectable
2eikP-3sp1A:
undetectable		 2eikN-3sp1A:
20.43
2eikP-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.45A 2eilA-3sp1A:
undetectable
2eilC-3sp1A:
undetectable		 2eilA-3sp1A:
20.43
2eilC-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.46A 2eilN-3sp1A:
undetectable
2eilP-3sp1A:
undetectable		 2eilN-3sp1A:
20.43
2eilP-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 6 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.48A 2eimA-3sp1A:
undetectable
2eimC-3sp1A:
undetectable		 2eimA-3sp1A:
20.43
2eimC-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 6 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.45A 2einA-3sp1A:
undetectable
2einC-3sp1A:
undetectable		 2einA-3sp1A:
20.43
2einC-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 6 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.44A 2einN-3sp1A:
undetectable
2einP-3sp1A:
undetectable		 2einN-3sp1A:
20.43
2einP-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 193
GLY A 192
GLY A 190
ILE A 218
ALA A 220
 None
NAD  A 482 (-3.5A)
NAD  A 482 (-3.0A)
None
NAD  A 482 ( 3.7A)
 0.71A 2fk8A-1v59A:
2.7		 2fk8A-1v59A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES
(Anoxybacillus
ayderensis) 		5 / 11 GLY A 113
TYR A  61
PHE A 112
VAL A  53
GLU A 103
 None
None
None
None
CA  A1482 ( 4.9A)
 1.32A 2fl5A-5a2aA:
undetectable
2fl5B-5a2aA:
undetectable
2fl5F-5a2aA:
undetectable		 2fl5A-5a2aA:
17.36
2fl5B-5a2aA:
17.59
2fl5F-5a2aA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 12 GLU A 235
ILE A 152
LEU A 228
GLY A 237
ILE A 236
 None
NAP  A 482 ( 4.2A)
None
None
NAP  A 482 (-3.6A)
 0.90A 2ogyA-3jz4A:
undetectable		 2ogyA-3jz4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 12 GLU A 235
ILE A 152
LEU A 228
GLY A 237
ILE A 236
 None
NAP  A 482 ( 4.2A)
None
None
NAP  A 482 (-3.6A)
 0.94A 2ogyB-3jz4A:
undetectable		 2ogyB-3jz4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_A_BEZA500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3obz PHYTANOYL-COA
DIOXYGENASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 HIS A 263
ASP A 158
HIS A 156
SER A 248
LEU A 187
 AKG  A 481 ( 4.8A)
FE2  A 482 ( 2.6A)
FE2  A 482 ( 3.4A)
AKG  A 481 (-2.5A)
None
 1.34A 2q0jA-3obzA:
undetectable		 2q0jA-3obzA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 11 ASP A  75
HIS A  76
HIS A 158
ASP A 179
HIS A 418
 ZN  A 481 ( 2.6A)
ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
ZN  A 481 (-2.5A)
ZN  A 481 ( 3.4A)
 0.60A 2q0jB-2i7tA:
11.7		 2q0jB-2i7tA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 8 LEU A 315
SER A  15
VAL A 426
GLY A 401
 ADP  A1482 (-4.9A)
None
None
ADP  A1482 ( 3.9A)
 1.11A 2qd5A-2cgjA:
undetectable		 2qd5A-2cgjA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 8 LEU A 315
SER A  15
VAL A 426
GLY A 401
 ADP  A1482 (-4.9A)
None
None
ADP  A1482 ( 3.9A)
 1.07A 2qd5B-2cgjA:
undetectable		 2qd5B-2cgjA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 10 LEU A 283
VAL A 288
GLY A 287
GLY A 280
LEU A 281
 None
None
None
None
FAD  A8482 (-4.7A)
 0.94A 2v3kA-2eq9A:
2.2		 2v3kA-2eq9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN
(Azospirillum
brasilense) 		4 / 8 ILE G  65
TRP G  68
VAL G 123
CYH G 104
 SF4  G 483 (-4.7A)
None
None
SF4  G 482 (-2.4A)
 0.95A 2xz5A-2vdcG:
undetectable
2xz5C-2vdcG:
undetectable		 2xz5A-2vdcG:
18.74
2xz5C-2vdcG:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN
(Azospirillum
brasilense) 		4 / 8 ILE G  65
TRP G  68
VAL G 123
CYH G 104
 SF4  G 483 (-4.7A)
None
None
SF4  G 482 (-2.4A)
 0.94A 2xz5C-2vdcG:
undetectable
2xz5D-2vdcG:
undetectable		 2xz5C-2vdcG:
18.74
2xz5D-2vdcG:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		5 / 12 LEU A 330
VAL A 289
SER A 445
PHE A 157
ASN A 156
 None
None
None
None
NAP  A 482 (-3.3A)
 1.47A 2y00A-3jz4A:
undetectable		 2y00A-3jz4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.45A 2y69A-3sp1A:
undetectable
2y69C-3sp1A:
undetectable		 2y69A-3sp1A:
20.43
2y69C-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 6 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.48A 2zxwA-3sp1A:
undetectable
2zxwC-3sp1A:
undetectable		 2zxwA-3sp1A:
20.43
2zxwC-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 6 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.46A 2zxwN-3sp1A:
undetectable
2zxwP-3sp1A:
undetectable		 2zxwN-3sp1A:
20.43
2zxwP-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.49A 3abkA-3sp1A:
undetectable
3abkC-3sp1A:
undetectable		 3abkA-3sp1A:
20.43
3abkC-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.49A 3abkN-3sp1A:
undetectable
3abkP-3sp1A:
undetectable		 3abkN-3sp1A:
20.43
3abkP-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.46A 3abmN-3sp1A:
undetectable
3abmP-3sp1A:
undetectable		 3abmN-3sp1A:
20.43
3abmP-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 6 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.44A 3ag1A-3sp1A:
undetectable
3ag1C-3sp1A:
undetectable		 3ag1A-3sp1A:
20.43
3ag1C-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 6 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.47A 3ag1N-3sp1A:
undetectable
3ag1P-3sp1A:
undetectable		 3ag1N-3sp1A:
20.43
3ag1P-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.45A 3ag2A-3sp1A:
undetectable
3ag2C-3sp1A:
undetectable		 3ag2A-3sp1A:
20.43
3ag2C-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.42A 3ag2N-3sp1A:
undetectable
3ag2P-3sp1A:
undetectable		 3ag2N-3sp1A:
20.43
3ag2P-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.49A 3ag3A-3sp1A:
undetectable
3ag3C-3sp1A:
undetectable		 3ag3A-3sp1A:
20.43
3ag3C-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.46A 3ag3N-3sp1A:
undetectable
3ag3P-3sp1A:
undetectable		 3ag3N-3sp1A:
20.43
3ag3P-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.47A 3ag4A-3sp1A:
undetectable
3ag4C-3sp1A:
undetectable		 3ag4A-3sp1A:
20.43
3ag4C-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.44A 3ag4N-3sp1A:
undetectable
3ag4P-3sp1A:
undetectable		 3ag4N-3sp1A:
20.43
3ag4P-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 6 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.48A 3asnA-3sp1A:
undetectable
3asnC-3sp1A:
undetectable		 3asnA-3sp1A:
20.43
3asnC-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 2ilu ALDEHYDE
DEHYDROGENASE A
(Escherichia
coli) 		5 / 11 VAL A  91
GLY A  95
ILE A 329
PRO A  29
THR A  31
 None
None
NDP  A 482 (-4.9A)
None
None
 1.14A 3bjwB-2iluA:
undetectable		 3bjwB-2iluA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 2ilu ALDEHYDE
DEHYDROGENASE A
(Escherichia
coli) 		5 / 11 VAL A  91
GLY A  95
ILE A 329
PRO A  29
THR A  31
 None
None
NDP  A 482 (-4.9A)
None
None
 1.13A 3bjwH-2iluA:
undetectable		 3bjwH-2iluA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3gip N-ACYL-D-GLUTAMATE
DEACYLASE
(Bordetella
bronchiseptica) 		5 / 10 GLY A 366
HIS A  68
HIS A  66
TYR A 282
HIS A 248
 None
ACY  A 481 (-4.8A)
ACY  A 481 ( 4.9A)
FMT  A 482 (-4.4A)
ZN  A 484 (-3.3A)
 1.09A 3boyA-3gipA:
undetectable
3boyC-3gipA:
undetectable		 3boyA-3gipA:
14.38
3boyC-3gipA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3gip N-ACYL-D-GLUTAMATE
DEACYLASE
(Bordetella
bronchiseptica) 		5 / 10 HIS A  66
TYR A 282
HIS A 248
GLY A 366
HIS A  68
 ACY  A 481 ( 4.9A)
FMT  A 482 (-4.4A)
ZN  A 484 (-3.3A)
None
ACY  A 481 (-4.8A)
 1.09A 3boyA-3gipA:
undetectable
3boyB-3gipA:
undetectable		 3boyA-3gipA:
14.38
3boyB-3gipA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3gip N-ACYL-D-GLUTAMATE
DEACYLASE
(Bordetella
bronchiseptica) 		5 / 10 HIS A  66
TYR A 282
HIS A 248
GLY A 366
HIS A  68
 ACY  A 481 ( 4.9A)
FMT  A 482 (-4.4A)
ZN  A 484 (-3.3A)
None
ACY  A 481 (-4.8A)
 1.08A 3boyB-3gipA:
undetectable
3boyC-3gipA:
undetectable		 3boyB-3gipA:
14.38
3boyC-3gipA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA
(Escherichia
coli) 		3 / 3 TYR A 383
ASP A 451
HIS A  45
 None
BR  A1482 ( 4.3A)
None
 0.97A 3e23A-2xhyA:
undetectable		 3e23A-2xhyA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		3 / 3 THR A 234
GLU A 385
HIS A 342
 None
NAP  A 482 (-3.5A)
None
 0.84A 3g1uB-3jz4A:
5.0		 3g1uB-3jz4A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR
(Yersinia
enterocolitica) 		5 / 12 ASN A 125
VAL A  69
TYR A  63
PHE A  98
TYR A  50
 482  A 201 (-3.7A)
482  A 201 (-4.6A)
None
482  A 201 (-3.5A)
482  A 201 (-4.5A)
 1.50A 3megA-5l09A:
undetectable		 3megA-5l09A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		3 / 3 HIS A 242
HIS A 246
HIS A 247
 AMP  A 482 (-4.2A)
ZN  A 481 (-3.3A)
None
 0.80A 3mihA-3sp1A:
undetectable		 3mihA-3sp1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		3 / 3 HIS A 246
HIS A 247
HIS A 242
 ZN  A 481 (-3.3A)
None
AMP  A 482 (-4.2A)
 0.45A 3mihA-3sp1A:
undetectable		 3mihA-3sp1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		3 / 3 HIS A 247
HIS A 242
HIS A 246
 None
AMP  A 482 (-4.2A)
ZN  A 481 (-3.3A)
 0.84A 3mihA-3sp1A:
undetectable		 3mihA-3sp1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 12 GLY A 424
GLY A 401
GLN A 411
VAL A 421
ALA A 414
 None
ADP  A1482 ( 3.9A)
None
None
None
 1.20A 3t7vA-2cgjA:
undetectable		 3t7vA-2cgjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 163
ILE A 261
THR A 245
VAL A 283
 None
None
None
NAD  A 482 (-4.0A)
 0.86A 3ua5A-1v59A:
undetectable		 3ua5A-1v59A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 8 GLY A 190
GLY A 191
GLY A 199
LEU A 234
VAL A 209
 NAD  A 482 (-3.0A)
NAD  A 482 ( 4.6A)
None
None
None
 1.27A 3v1nA-1v59A:
undetectable		 3v1nA-1v59A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 5 VAL A 187
SER A 166
GLY A 273
ARG A 274
 FAD  A8482 ( 4.5A)
FAD  A8482 (-3.6A)
None
FAD  A8482 (-3.6A)
 1.30A 3v4tA-2eq9A:
undetectable
3v4tD-2eq9A:
1.5		 3v4tA-2eq9A:
23.78
3v4tD-2eq9A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 5l09 QUORUM-SENSING
TRANSCRIPTIONAL
ACTIVATOR
(Yersinia
enterocolitica) 		5 / 12 TYR A  50
LEU A  29
SER A 139
PHE A 112
LEU A 124
 482  A 201 (-4.5A)
None
None
None
None
 1.41A 3vw1B-5l09A:
undetectable		 3vw1B-5l09A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 6 GLY A  12
ASP A 162
ASP A  10
GLU A 175
 ADP  A1482 ( 4.0A)
None
None
None
 1.03A 3vywC-2cgjA:
undetectable		 3vywC-2cgjA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN
(Azospirillum
brasilense) 		4 / 8 TRP G  68
VAL G 123
CYH G 104
ILE G  65
 None
None
SF4  G 482 (-2.4A)
SF4  G 483 (-4.7A)
 0.98A 4afgD-2vdcG:
undetectable
4afgE-2vdcG:
undetectable		 4afgD-2vdcG:
17.60
4afgE-2vdcG:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN
(Azospirillum
brasilense) 		4 / 8 TRP G  68
VAL G 123
CYH G 104
ILE G  65
 None
None
SF4  G 482 (-2.4A)
SF4  G 483 (-4.7A)
 1.04A 4aftD-2vdcG:
undetectable
4aftE-2vdcG:
undetectable		 4aftD-2vdcG:
18.74
4aftE-2vdcG:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 ALA A  13
SER A  14
THR A 181
SER A 235
TRP A  82
 ADP  A1482 ( 4.9A)
ADP  A1482 (-2.4A)
None
None
None
 1.48A 4bb2A-2cgjA:
undetectable
4bb2B-2cgjA:
0.0		 4bb2A-2cgjA:
23.39
4bb2B-2cgjA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN
(Azospirillum
brasilense) 		4 / 8 TRP G  68
VAL G 123
CYH G 104
ILE G  65
 None
None
SF4  G 482 (-2.4A)
SF4  G 483 (-4.7A)
 1.08A 4bqtC-2vdcG:
undetectable
4bqtD-2vdcG:
undetectable		 4bqtC-2vdcG:
18.74
4bqtD-2vdcG:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		3 / 3 HIS A 242
GLU A 250
ASN A  65
 AMP  A 482 (-4.2A)
ZN  A 481 (-3.9A)
ZN  A 481 ( 4.5A)
 0.96A 4bupB-3sp1A:
undetectable		 4bupB-3sp1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 HIS A  71
HIS A  73
ASP A  75
HIS A 158
HIS A 418
 ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 482 ( 3.3A)
ZN  A 481 ( 3.4A)
 0.78A 4c1dB-2i7tA:
9.1		 4c1dB-2i7tA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 TYR A 357
HIS A  71
HIS A  73
ASP A  75
HIS A 418
 None
ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 481 ( 3.4A)
 1.44A 4c1dB-2i7tA:
9.1		 4c1dB-2i7tA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		6 / 11 VAL A 359
HIS A  71
HIS A  73
ASP A  75
HIS A 158
HIS A 418
 None
ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 482 ( 3.3A)
ZN  A 481 ( 3.4A)
 1.09A 4c1fA-2i7tA:
7.5
4c1fB-2i7tA:
9.7		 4c1fA-2i7tA:
19.83
4c1fB-2i7tA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 9 HIS A  71
HIS A  73
ASP A  75
HIS A 158
HIS A 418
 ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 482 ( 3.3A)
ZN  A 481 ( 3.4A)
 0.80A 4c1hA-2i7tA:
10.5		 4c1hA-2i7tA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 HIS A  73
ASP A  75
HIS A 158
HIS A 418
 ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 482 ( 3.3A)
ZN  A 481 ( 3.4A)
 0.78A 4exsB-2i7tA:
7.2		 4exsB-2i7tA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ilu ALDEHYDE
DEHYDROGENASE A
(Escherichia
coli) 		4 / 7 TRP A 152
GLY A 253
GLY A 254
GLU A 251
 NDP  A 482 (-4.1A)
None
SO4  A 480 (-3.1A)
None
 0.90A 4fgkB-2iluA:
undetectable		 4fgkB-2iluA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		3 / 3 ASP A 285
ARG A 313
ASP A 259
 None
None
JW5  A 482 (-2.9A)
 0.86A 4fp9A-2qcmA:
undetectable		 4fp9A-2qcmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		3 / 3 ASP A 285
ARG A 313
ASP A 259
 None
None
JW5  A 482 (-2.9A)
 0.86A 4fp9C-2qcmA:
undetectable		 4fp9C-2qcmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		3 / 3 ASP A 285
ARG A 313
ASP A 259
 None
None
JW5  A 482 (-2.9A)
 0.88A 4fp9F-2qcmA:
undetectable		 4fp9F-2qcmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2ci8 CYTOPLASMIC PROTEIN
NCK1
(Homo
sapiens) 		4 / 8 ASP A 316
ASN A 315
GLU A 336
ASP A 309
 None
None
None
1PE  A 482 (-3.7A)
 1.19A 4gkhB-2ci8A:
undetectable		 4gkhB-2ci8A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 5 HIS A  76
HIS A 158
HIS A 396
HIS A 418
ASP A  75
 ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
ZN  A 481 ( 3.4A)
ZN  A 481 ( 2.6A)
 1.17A 4h9mA-2i7tA:
undetectable		 4h9mA-2i7tA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 12 GLY A 401
GLY A 402
GLY A 403
SER A 261
ALA A 241
 ADP  A1482 ( 3.9A)
ADP  A1482 (-3.2A)
ADP  A1482 (-3.9A)
None
None
 0.92A 4htfA-2cgjA:
undetectable		 4htfA-2cgjA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 12 GLY A 401
GLY A 402
GLY A 403
SER A 261
ALA A 241
 ADP  A1482 ( 3.9A)
ADP  A1482 (-3.2A)
ADP  A1482 (-3.9A)
None
None
 0.94A 4htfB-2cgjA:
undetectable		 4htfB-2cgjA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		3 / 3 GLY A 285
GLU A 385
THR A 386
 None
NAP  A 482 (-3.5A)
None
 0.48A 4kouA-3jz4A:
undetectable		 4kouA-3jz4A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2ilu ALDEHYDE
DEHYDROGENASE A
(Escherichia
coli) 		5 / 12 GLY A 229
GLY A 253
LEU A 250
ALA A 233
ILE A 149
 NDP  A 482 (-3.5A)
None
OCS  A 249 ( 3.7A)
NDP  A 482 (-3.2A)
NDP  A 482 (-4.1A)
 1.12A 4krhB-2iluA:
4.8		 4krhB-2iluA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 3obz PHYTANOYL-COA
DIOXYGENASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 4 HIS A 156
GLU A 243
HIS A 241
LEU A 264
 FE2  A 482 ( 3.4A)
None
None
None
 1.41A 4m2rA-3obzA:
undetectable		 4m2rA-3obzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 12 ILE A  15
VAL A  38
LEU A 115
GLY A 134
LEU A 281
 FAD  A8482 (-4.5A)
FAD  A8482 ( 4.8A)
None
None
FAD  A8482 (-4.7A)
 0.90A 4o1zA-2eq9A:
undetectable		 4o1zA-2eq9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 10 LEU A 300
LEU A 318
ILE A 319
LEU A 315
LEU A 409
 ADP  A1482 (-3.6A)
None
None
ADP  A1482 (-4.9A)
None
 1.07A 4odoC-2cgjA:
undetectable		 4odoC-2cgjA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 12 THR A 304
VAL A 306
THR A 278
GLU A 284
ILE A  15
 None
None
None
None
FAD  A8482 (-4.5A)
 1.49A 4s0vA-2eq9A:
3.0		 4s0vA-2eq9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 6 HIS A  76
HIS A 158
HIS A 396
HIS A 418
ASP A  75
 ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
ZN  A 481 ( 3.4A)
ZN  A 481 ( 2.6A)
 1.17A 4ubpC-2i7tA:
undetectable		 4ubpC-2i7tA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 8 ALA A 146
VAL A  14
GLY A  20
ALA A 325
GLY A 329
 FAD  A8482 (-4.7A)
None
FAD  A8482 (-3.5A)
FAD  A8482 (-3.6A)
None
 1.24A 4zjzB-2eq9A:
undetectable		 4zjzB-2eq9A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 HIS A  73
ASP A  75
HIS A 158
HIS A 418
 ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 482 ( 3.3A)
ZN  A 481 ( 3.4A)
 0.75A 5a5zA-2i7tA:
10.2		 5a5zA-2i7tA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 1s44 CRUSTACYANIN A1
SUBUNIT
(Homarus
gammarus) 		4 / 8 ASN A  43
PRO A  44
PHE A 134
PHE A   6
 MPD  A 482 (-3.3A)
None
MPD  A 481 ( 3.8A)
None
 1.05A 5amkA-1s44A:
0.0		 5amkA-1s44A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		6 / 11 HIS A  71
HIS A  73
ASP A  75
HIS A  76
HIS A 158
HIS A 418
 ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
ZN  A 481 ( 3.4A)
 0.34A 5ayaA-2i7tA:
10.8		 5ayaA-2i7tA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.47A 5b1aN-3sp1A:
undetectable
5b1aP-3sp1A:
undetectable		 5b1aN-3sp1A:
20.43
5b1aP-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.47A 5b1bN-3sp1A:
undetectable
5b1bP-3sp1A:
undetectable		 5b1bN-3sp1A:
20.43
5b1bP-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN
(Azospirillum
brasilense) 		4 / 7 CYH G  98
ILE G  93
LEU G 449
ALA G 453
 SF4  G 482 (-2.5A)
None
FAD  G 484 (-3.9A)
FAD  G 484 (-3.6A)
 0.94A 5hrqE-2vdcG:
undetectable
5hrqF-2vdcG:
undetectable
5hrqJ-2vdcG:
undetectable		 5hrqE-2vdcG:
5.84
5hrqF-2vdcG:
5.63
5hrqJ-2vdcG:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 5 PRO A  54
HIS A  71
LEU A 128
PHE A 241
 None
ZN  A 482 (-3.5A)
None
None
 1.49A 5igjA-2i7tA:
undetectable		 5igjA-2i7tA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2ilu ALDEHYDE
DEHYDROGENASE A
(Escherichia
coli) 		4 / 7 GLY A 253
GLY A 229
LEU A 158
GLU A 289
 None
NDP  A 482 (-3.5A)
None
None
 0.84A 5izfA-2iluA:
undetectable		 5izfA-2iluA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 12 GLU A 334
ILE A 331
LEU A  12
ILE A 312
ALA A 146
 None
None
None
None
FAD  A8482 (-4.7A)
 1.09A 5j7wC-2eq9A:
undetectable		 5j7wC-2eq9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 12 GLU A 334
ILE A 331
LEU A  12
ILE A 312
ALA A 146
 None
None
None
None
FAD  A8482 (-4.7A)
 1.08A 5j7wD-2eq9A:
undetectable		 5j7wD-2eq9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 12 GLY A  18
GLY A  20
VAL A 103
VAL A  46
LEU A  48
 FAD  A8482 (-3.6A)
FAD  A8482 (-3.5A)
None
FAD  A8482 ( 3.9A)
None
 1.18A 5kocB-2eq9A:
undetectable		 5kocB-2eq9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 HIS A 396
HIS A 418
HIS A  71
HIS A  73
LEU A  74
 SO4  A 491 (-4.0A)
ZN  A 481 ( 3.4A)
ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
None
 1.32A 5m8nA-2i7tA:
undetectable		 5m8nA-2i7tA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 HIS A  73
HIS A 396
GLY A 157
VAL A 159
 ZN  A 482 ( 3.2A)
SO4  A 491 (-4.0A)
None
None
 0.99A 5m8rC-2i7tA:
undetectable		 5m8rC-2i7tA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 VAL A 406
ASP A 357
HIS A 479
LEU A 482
LEU A 354
 VAL  A 406 ( 0.6A)
ASP  A 357 ( 0.6A)
HIS  A 479 ( 1.0A)
LEU  A 482 ( 0.6A)
LEU  A 354 ( 0.6A)
 1.14A 5nd7B-2nvvA:
undetectable		 5nd7B-2nvvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A 179
HIS A  76
HIS A 418
HIS A 158
 ZN  A 481 (-2.5A)
ZN  A 481 (-3.4A)
ZN  A 481 ( 3.4A)
ZN  A 482 ( 3.3A)
 0.88A 5nekD-2i7tA:
undetectable		 5nekD-2i7tA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		7 / 10 HIS A  71
HIS A  73
HIS A  76
HIS A 158
ASP A 179
TYR A 207
HIS A 396
 ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
ZN  A 481 (-2.5A)
None
SO4  A 491 (-4.0A)
 0.61A 5nzwA-2i7tA:
16.4		 5nzwA-2i7tA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 HIS A  76
HIS A 418
HIS A  71
ASP A 179
HIS A 158
 ZN  A 481 (-3.4A)
ZN  A 481 ( 3.4A)
ZN  A 482 (-3.5A)
ZN  A 481 (-2.5A)
ZN  A 482 ( 3.3A)
 0.96A 5nzwA-2i7tA:
16.4		 5nzwA-2i7tA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		5 / 10 HIS A 158
HIS A  71
HIS A 396
ASP A 179
HIS A 418
 ZN  A 482 ( 3.3A)
ZN  A 482 (-3.5A)
SO4  A 491 (-4.0A)
ZN  A 481 (-2.5A)
ZN  A 481 ( 3.4A)
 1.02A 5nzwA-2i7tA:
16.4		 5nzwA-2i7tA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O87_A_NCTA601_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN
(Azospirillum
brasilense) 		5 / 10 TRP G  68
VAL G 123
CYH G 104
VAL G 118
ILE G  65
 None
None
SF4  G 482 (-2.4A)
SF4  G 483 (-4.1A)
SF4  G 483 (-4.7A)
 1.35A 5o87A-2vdcG:
0.0
5o87B-2vdcG:
0.0		 5o87A-2vdcG:
10.04
5o87B-2vdcG:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE
(Methylobacillus
flagellatus) 		5 / 12 GLN A 405
ALA A 404
GLU A 160
ILE A 324
ASP A 318
 None
None
GOL  A 491 (-3.3A)
GOL  A 482 (-4.5A)
GOL  A 491 ( 3.3A)
 1.25A 5vlmG-3n6xA:
undetectable		 5vlmG-3n6xA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 8 GLY A  20
GLY A 329
LEU A 330
ALA A 333
 FAD  A8482 (-3.5A)
None
None
None
 0.75A 5vw5A-2eq9A:
2.2		 5vw5A-2eq9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		5 / 12 ALA A 251
PRO A 252
GLY A 153
GLY A 104
LEU A  34
 AKA  A 600 ( 3.8A)
None
None
None
SO4  A3482 (-4.6A)
 1.12A 5wwsA-1q0zA:
undetectable		 5wwsA-1q0zA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 6 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.46A 5x19N-3sp1A:
undetectable
5x19P-3sp1A:
undetectable		 5x19N-3sp1A:
20.43
5x19P-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]
(Escherichia
coli) 		4 / 8 ALA A  90
THR A  94
ALA A 284
TRP A 155
 None
None
None
NAP  A 482 (-3.9A)
 0.66A 5x2tI-3jz4A:
undetectable
5x2tJ-3jz4A:
undetectable
5x2tK-3jz4A:
undetectable
5x2tL-3jz4A:
undetectable		 5x2tI-3jz4A:
17.13
5x2tJ-3jz4A:
16.70
5x2tK-3jz4A:
17.13
5x2tL-3jz4A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 THR A 206
GLU A 204
HIS A 158
 None
None
ZN  A 482 ( 3.3A)
 0.84A 5xioA-2i7tA:
undetectable		 5xioA-2i7tA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 THR A 206
GLU A 204
HIS A 158
 None
None
ZN  A 482 ( 3.3A)
 0.84A 5xiqB-2i7tA:
undetectable		 5xiqB-2i7tA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		3 / 3 THR A 206
GLU A 204
HIS A 158
 None
None
ZN  A 482 ( 3.3A)
 0.87A 5xiqD-2i7tA:
undetectable		 5xiqD-2i7tA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.48A 5zcqN-3sp1A:
undetectable
5zcqP-3sp1A:
undetectable		 5zcqN-3sp1A:
20.43
5zcqP-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		6 / 12 LEU A 106
GLY A 104
GLU A  39
LEU A  99
GLY A 101
GLY A 102
 None
None
FAD  A8482 (-2.7A)
None
None
None
 1.21A 5zhmB-2eq9A:
undetectable		 5zhmB-2eq9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 HIS A  73
ASP A  75
HIS A 158
HIS A 418
 ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 482 ( 3.3A)
ZN  A 481 ( 3.4A)
 0.83A 5zj8A-2i7tA:
10.5		 5zj8A-2i7tA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens) 		4 / 8 MET A 331
HIS A  73
ASP A  75
HIS A 158
 None
ZN  A 482 ( 3.2A)
ZN  A 481 ( 2.6A)
ZN  A 482 ( 3.3A)
 1.03A 5zj8A-2i7tA:
10.5		 5zj8A-2i7tA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 3hbu SECRETED PROTEASE C
(Dickeya
chrysanthemi) 		5 / 7 GLY P 346
GLY P 345
GLY P 363
GLY P 381
GLY P 382
 CA  P 482 (-4.4A)
CA  P 482 ( 4.7A)
CA  P 482 (-4.4A)
CA  P 485 (-4.5A)
CA  P 484 (-4.0A)
 0.99A 6ag0A-3hbuP:
undetectable		 6ag0A-3hbuP:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN
(Azospirillum
brasilense) 		5 / 12 VAL G  83
LEU G 449
ARG G 203
VAL G 450
GLY G 121
 None
FAD  G 484 (-3.9A)
None
FAD  G 484 (-3.7A)
SF4  G 482 ( 4.0A)
 1.25A 6brdA-2vdcG:
6.4		 6brdA-2vdcG:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		 3gip N-ACYL-D-GLUTAMATE
DEACYLASE
(Bordetella
bronchiseptica) 		5 / 10 GLY A 187
TYR A 190
ASP A 365
TYR A 282
TYR A 343
 None
ACY  A 481 (-4.6A)
ACY  A 481 ( 2.5A)
FMT  A 482 (-4.4A)
FMT  A 483 (-4.4A)
 1.44A 6cgdA-3gipA:
undetectable		 6cgdA-3gipA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 GLY A  12
ASP A  10
ILE A  79
 ADP  A1482 ( 4.0A)
None
None
 0.56A 6dgxB-2cgjA:
undetectable		 6dgxB-2cgjA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 12 VAL A 298
ASP A 291
GLU A 150
PRO A 318
GLY A 313
 None
None
None
None
FAD  A8482 (-3.4A)
 1.34A 6gnfC-2eq9A:
undetectable		 6gnfC-2eq9A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens) 		3 / 3 ASP A 289
ASP A 285
ASN A 341
 None
None
JW5  A 482 (-4.3A)
 0.83A 6gngB-2qcmA:
undetectable		 6gngB-2qcmA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 6 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.45A 6nknA-3sp1A:
0.4
6nknC-3sp1A:
undetectable		 6nknA-3sp1A:
20.43
6nknC-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.47A 6nmfN-3sp1A:
undetectable
6nmfP-3sp1A:
undetectable		 6nmfN-3sp1A:
20.43
6nmfP-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 6 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.49A 6nmpA-3sp1A:
undetectable
6nmpC-3sp1A:
undetectable		 6nmpA-3sp1A:
20.43
6nmpC-3sp1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sp1 CYSTEINYL-TRNA
SYNTHETASE
(Borreliella
burgdorferi) 		4 / 7 HIS A 242
ASP A  68
THR A  67
HIS A 236
 AMP  A 482 (-4.2A)
None
None
None
 1.45A 6nmpN-3sp1A:
0.2
6nmpP-3sp1A:
undetectable		 6nmpN-3sp1A:
20.43
6nmpP-3sp1A:
19.49