SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '42Y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EIZ_A_SAMA301_0 (FTSJ)	5wgc	DAUNORUBICIN-DOXORUB ICIN POLYKETIDE SYNTHASE (Streptomyces peucetius)	5 / 12	ALA A 84 GLY A 169 GLY A 299 GLY A 300 LEU A 62	None None None 42Y A 118 ( 3.2A) None	0.99A	1eizA-5wgcA: undetectable	1eizA-5wgcA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EJ0_A_SAMA301_0 (FTSJ)	5wgc	DAUNORUBICIN-DOXORUB ICIN POLYKETIDE SYNTHASE (Streptomyces peucetius)	5 / 12	ALA A 84 GLY A 169 GLY A 299 GLY A 300 LEU A 62	None None None 42Y A 118 ( 3.2A) None	0.99A	1ej0A-5wgcA: undetectable	1ej0A-5wgcA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UAK_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	5wgc	DAUNORUBICIN-DOXORUB ICIN POLYKETIDE SYNTHASE (Streptomyces peucetius)	6 / 12	LEU A 86 SER A 85 GLY A 120 LEU A 298 GLY A 301 GLY A 300	42Y A 118 ( 4.7A) None 42Y A 118 ( 4.9A) None None 42Y A 118 ( 3.2A)	1.29A	1uakA-5wgcA: undetectable	1uakA-5wgcA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UAK_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	5wgc	DAUNORUBICIN-DOXORUB ICIN POLYKETIDE SYNTHASE (Streptomyces peucetius)	6 / 12	SER A 85 GLN A 89 GLY A 120 LEU A 298 GLY A 301 GLY A 300	None None 42Y A 118 ( 4.9A) None None 42Y A 118 ( 3.2A)	1.34A	1uakA-5wgcA: undetectable	1uakA-5wgcA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UAK_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	5wgc	DAUNORUBICIN-DOXORUB ICIN POLYKETIDE SYNTHASE (Streptomyces peucetius)	6 / 12	SER A 85 GLN A 89 GLY A 121 LEU A 298 GLY A 301 GLY A 300	None None None None None 42Y A 118 ( 3.2A)	1.23A	1uakA-5wgcA: undetectable	1uakA-5wgcA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KOE_H_TR6H101_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B E-SITE DNA4)	5wgc	DAUNORUBICIN-DOXORUB ICIN POLYKETIDE SYNTHASE (Streptomyces peucetius)	4 / 7	SER A 326 GLY A 146 ASP A 147 GLU A 113	42Y A 118 ( 3.7A) None None None	0.76A	4koeA-5wgcA: undetectable 4koeB-5wgcA: undetectable 4koeD-5wgcA: undetectable	4koeA-5wgcA: 10.08 4koeB-5wgcA: 10.08 4koeD-5wgcA: 13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YJI_A_TYLA502_1 (ARYL ACYLAMIDASE)	5wgc	DAUNORUBICIN-DOXORUB ICIN POLYKETIDE SYNTHASE (Streptomyces peucetius)	4 / 7	SER A 326 GLY A 120 GLY A 121 ILE A 304	42Y A 118 ( 3.7A) 42Y A 118 ( 4.9A) None None	0.73A	4yjiA-5wgcA: undetectable	4yjiA-5wgcA: 11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z53_H_TR6H101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A E-SITE DNA)	5wgc	DAUNORUBICIN-DOXORUB ICIN POLYKETIDE SYNTHASE (Streptomyces peucetius)	4 / 7	GLY A 146 ASP A 147 GLU A 113 SER A 326	None None None 42Y A 118 ( 3.7A)	0.74A	4z53A-5wgcA: undetectable 4z53B-5wgcA: undetectable	4z53A-5wgcA: 7.21 4z53B-5wgcA: 7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6IFT_A_SAMA301_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A)	5wgc	DAUNORUBICIN-DOXORUB ICIN POLYKETIDE SYNTHASE (Streptomyces peucetius)	5 / 12	ILE A 304 GLY A 301 GLY A 299 ALA A 166 LEU A 86	None None None None 42Y A 118 ( 4.7A)	0.97A	6iftA-5wgcA: undetectable	6iftA-5wgcA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EIZ_A_SAMA301_0","FTSJ","5wgc","DAUNORUBICIN-DOXORUBICIN POLYKETIDE SYNTHASE","Streptomyces peucetius",5,"ALA A  84;GLY A 169;GLY A 299;GLY A 300;LEU A  62","None;None;None;42Y A 118 ( 3.2A);None","0.99A","1eizA-5wgcA:undetectable",null],["1EJ0_A_SAMA301_0","FTSJ","5wgc","DAUNORUBICIN-DOXORUBICIN POLYKETIDE SYNTHASE","Streptomyces peucetius",5,"ALA A  84;GLY A 169;GLY A 299;GLY A 300;LEU A  62","None;None;None;42Y A 118 ( 3.2A);None","0.99A","1ej0A-5wgcA:undetectable","1eizA-5wgcA:undetectable"],["1UAK_A_SAMA301_0","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","5wgc","DAUNORUBICIN-DOXORUBICIN POLYKETIDE SYNTHASE","Streptomyces peucetius",6,"LEU A  86;SER A  85;GLY A 120;LEU A 298;GLY A 301;GLY A 300","42Y A 118 ( 4.7A);None;42Y A 118 ( 4.9A);None;None;42Y A 118 ( 3.2A)","1.29A","1uakA-5wgcA:undetectable","1ej0A-5wgcA:undetectable"],["1UAK_A_SAMA301_0","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","5wgc","DAUNORUBICIN-DOXORUBICIN POLYKETIDE SYNTHASE","Streptomyces peucetius",6,"SER A  85;GLN A  89;GLY A 120;LEU A 298;GLY A 301;GLY A 300","None;None;42Y A 118 ( 4.9A);None;None;42Y A 118 ( 3.2A)","1.34A","1uakA-5wgcA:undetectable","1uakA-5wgcA:undetectable"],["1UAK_A_SAMA301_0","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","5wgc","DAUNORUBICIN-DOXORUBICIN POLYKETIDE SYNTHASE","Streptomyces peucetius",6,"SER A  85;GLN A  89;GLY A 121;LEU A 298;GLY A 301;GLY A 300","None;None;None;None;None;42Y A 118 ( 3.2A)","1.23A","1uakA-5wgcA:undetectable","1uakA-5wgcA:undetectable"],["4KOE_H_TR6H101_1","DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B;E-SITE DNA4","5wgc","DAUNORUBICIN-DOXORUBICIN POLYKETIDE SYNTHASE","Streptomyces peucetius",4,"SER A 326;GLY A 146;ASP A 147;GLU A 113","42Y A 118 ( 3.7A);None;None;None","0.76A","4koeA-5wgcA:undetectable;4koeB-5wgcA:undetectable;4koeD-5wgcA:undetectable","1uakA-5wgcA:undetectable"],["4YJI_A_TYLA502_1","ARYL ACYLAMIDASE","5wgc","DAUNORUBICIN-DOXORUBICIN POLYKETIDE SYNTHASE","Streptomyces peucetius",4,"SER A 326;GLY A 120;GLY A 121;ILE A 304","42Y A 118 ( 3.7A);42Y A 118 ( 4.9A);None;None","0.73A","4yjiA-5wgcA:undetectable","4koeA-5wgcA:10.08;4koeB-5wgcA:10.08;4koeD-5wgcA:13.86"],["4Z53_H_TR6H101_1","DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;E-SITE DNA","5wgc","DAUNORUBICIN-DOXORUBICIN POLYKETIDE SYNTHASE","Streptomyces peucetius",4,"GLY A 146;ASP A 147;GLU A 113;SER A 326","None;None;None;42Y A 118 ( 3.7A)","0.74A","4z53A-5wgcA:undetectable;4z53B-5wgcA:undetectable","4yjiA-5wgcA:11.20"],["6IFT_A_SAMA301_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A","5wgc","DAUNORUBICIN-DOXORUBICIN POLYKETIDE SYNTHASE","Streptomyces peucetius",5,"ILE A 304;GLY A 301;GLY A 299;ALA A 166;LEU A  86","None;None;None;None;42Y A 118 ( 4.7A)","0.97A","6iftA-5wgcA:undetectable","4z53A-5wgcA:7.21;4z53B-5wgcA:7.21"]]