SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '41U'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		4 / 7 TYR A 124
ILE A 128
GLY A 418
PHE A 390
 41U  A 605 ( 3.8A)
None
NA  A 602 ( 4.2A)
None
 1.02A 2vctD-4xnuA:
undetectable		 2vctD-4xnuA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		4 / 6 PHE A  43
GLY A 425
ALA A 428
LEU A 254
 41U  A 605 (-4.2A)
41U  A 605 ( 3.7A)
None
None
 0.88A 3bgdA-4xnuA:
undetectable		 3bgdA-4xnuA:
18.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM4_A_8PRA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		7 / 12 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 421
GLY A 425
ASP A 475
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
None
 0.73A 4mm4A-4xnuA:
40.2		 4mm4A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM4_B_8PRB603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 12 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.32A 4mm4B-4xnuA:
40.3		 4mm4B-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM5_A_SREA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		5 / 9 ASP A  46
GLY A 322
PHE A 325
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.85A 4mm5A-4xnuA:
40.4		 4mm5A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM5_A_SREA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 9 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.63A 4mm5A-4xnuA:
40.4		 4mm5A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM6_A_29EA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 12 ASP A  46
TYR A 124
PHE A 325
VAL A 327
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.7A)
None
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.77A 4mm6A-4xnuA:
40.4		 4mm6A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM6_A_29EA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		5 / 12 ASP A  46
TYR A 124
VAL A 327
SER A 421
GLY A 424
 41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
None
NA  A 602 ( 2.4A)
None
 0.94A 4mm6A-4xnuA:
40.4		 4mm6A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM6_A_29EA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		7 / 12 ASP A  46
VAL A 120
TYR A 123
TYR A 124
VAL A 327
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
None
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.69A 4mm6A-4xnuA:
40.4		 4mm6A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM7_A_29JA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		7 / 10 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 421
GLY A 425
ASP A 475
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
None
 0.71A 4mm7A-4xnuA:
42.0		 4mm7A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		5 / 12 ASP A  46
GLY A 322
PHE A 325
SER A 422
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
None
41U  A 605 ( 3.7A)
 0.99A 4mm8A-4xnuA:
42.2		 4mm8A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		7 / 12 ASP A  46
VAL A 120
TYR A 123
TYR A 124
GLY A 322
SER A 422
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
None
41U  A 605 ( 3.7A)
 0.80A 4mm8A-4xnuA:
42.2		 4mm8A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		7 / 12 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 422
GLY A 425
ASP A 475
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
None
41U  A 605 ( 3.7A)
None
 0.94A 4mm8A-4xnuA:
42.2		 4mm8A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM9_A_FVXA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		5 / 11 ASP A  46
GLY A 322
PHE A 325
SER A 421
GLY A 424
 41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
None
 0.92A 4mm9A-4xnuA:
41.6		 4mm9A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM9_A_FVXA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 11 ASP A  46
TYR A 124
GLY A 322
PHE A 325
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.72A 4mm9A-4xnuA:
41.6		 4mm9A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM9_A_FVXA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		7 / 11 ASP A  46
VAL A 120
TYR A 123
TYR A 124
GLY A 322
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.50A 4mm9A-4xnuA:
41.6		 4mm9A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM9_A_FVXA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		7 / 11 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 421
GLY A 425
ASP A 475
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
None
 0.69A 4mm9A-4xnuA:
41.6		 4mm9A-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MMA_A_CXXA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		5 / 11 TYR A 124
PHE A 325
SER A 421
SER A 422
GLY A 424
 41U  A 605 ( 3.8A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
None
None
 1.25A 4mmaA-4xnuA:
40.1		 4mmaA-4xnuA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MMA_A_CXXA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		5 / 11 TYR A 124
PHE A 325
SER A 421
SER A 422
GLY A 425
 41U  A 605 ( 3.8A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
None
41U  A 605 ( 3.7A)
 0.88A 4mmaA-4xnuA:
40.1		 4mmaA-4xnuA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		5 / 9 ASP A  46
GLY A 322
PHE A 325
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.79A 4mmbA-4xnuA:
40.9		 4mmbA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 9 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.58A 4mmbA-4xnuA:
40.9		 4mmbA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		5 / 10 ASP A  46
GLY A 322
PHE A 325
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.64A 4mmcA-4xnuA:
40.8		 4mmcA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		7 / 10 ASP A  46
VAL A 120
TYR A 123
TYR A 124
GLY A 322
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.55A 4mmcA-4xnuA:
40.8		 4mmcA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		7 / 10 ASP A  46
VAL A 120
TYR A 123
TYR A 124
SER A 421
GLY A 425
ASP A 475
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
None
 0.70A 4mmcA-4xnuA:
40.8		 4mmcA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		5 / 10 ASP A  46
GLY A 322
PHE A 325
SER A 422
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
None
41U  A 605 ( 3.7A)
 0.94A 4mmdA-4xnuA:
41.0		 4mmdA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 10 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 422
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
None
41U  A 605 ( 3.7A)
 0.82A 4mmdA-4xnuA:
41.0		 4mmdA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 12 ASP A  46
GLY A 322
PHE A 325
SER A 421
SER A 422
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
None
41U  A 605 ( 3.7A)
 0.82A 4mmdB-4xnuA:
41.0		 4mmdB-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 12 ASP A  46
TYR A 124
GLY A 322
SER A 421
SER A 422
GLY A 424
 41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
None
 1.23A 4mmdB-4xnuA:
41.0		 4mmdB-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		8 / 12 ASP A  46
VAL A 120
TYR A 123
TYR A 124
GLY A 322
SER A 421
SER A 422
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
41U  A 605 ( 3.7A)
 0.72A 4mmdB-4xnuA:
41.0		 4mmdB-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 9 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.54A 4mmeA-4xnuA:
40.9		 4mmeA-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 9 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.56A 4mmeB-4xnuA:
40.8		 4mmeB-4xnuA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		5 / 9 ASP A  46
TYR A 124
GLY A 322
SER A 421
GLY A 424
 41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
 1.00A 4mmfA-4xnuA:
40.9		 4mmfA-4xnuA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 9 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.68A 4mmfA-4xnuA:
40.9		 4mmfA-4xnuA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		5 / 9 ASP A  46
TYR A 124
GLY A 322
SER A 421
GLY A 424
 41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
 1.03A 4mmfB-4xnuA:
40.7		 4mmfB-4xnuA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 9 ASP A  46
VAL A 120
TYR A 124
GLY A 322
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.66A 4mmfB-4xnuA:
40.7		 4mmfB-4xnuA:
29.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XNX_A_41XA707_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		11 / 11 PHE A  43
ASP A  46
ALA A 117
VAL A 120
ASP A 121
TYR A 123
TYR A 124
GLY A 322
VAL A 327
SER A 421
GLY A 425
 41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 ( 3.7A)
41U  A 605 (-4.2A)
41U  A 605 ( 4.2A)
None
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
None
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.31A 4xnxA-4xnuA:
63.2		 4xnxA-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XNX_A_41XA707_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 11 PHE A  43
ASP A  46
ALA A 428
GLY A 322
SER A 421
GLY A 424
 41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
None
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
 1.28A 4xnxA-4xnuA:
63.2		 4xnxA-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XNX_A_41XA707_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		7 / 11 PHE A  43
ASP A  46
TYR A 124
GLY A 322
VAL A 327
SER A 421
GLY A 424
 41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
None
NA  A 602 ( 2.4A)
None
 0.92A 4xnxA-4xnuA:
63.2		 4xnxA-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		5 / 10 ASP A 121
ASP A  46
SER A 422
SER A 421
GLY A 418
 41U  A 605 ( 4.2A)
41U  A 605 ( 3.3A)
None
NA  A 602 ( 2.4A)
NA  A 602 ( 4.2A)
 1.38A 4xp1A-4xnuA:
63.0		 4xp1A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		9 / 10 PHE A  43
ASP A  46
ALA A 117
VAL A 120
ASP A 121
TYR A 124
SER A 421
SER A 422
GLY A 425
 41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 ( 3.7A)
41U  A 605 (-4.2A)
41U  A 605 ( 4.2A)
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
None
41U  A 605 ( 3.7A)
 0.58A 4xp1A-4xnuA:
63.0		 4xp1A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 10 PHE A  43
ASP A  46
TYR A 124
SER A 421
SER A 422
GLY A 424
 41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
NA  A 602 ( 2.4A)
None
None
 1.11A 4xp1A-4xnuA:
63.0		 4xp1A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 11 PHE A  43
ASP A  46
ALA A  48
GLY A 322
PHE A 325
SER A 421
 41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
NA  A 601 ( 4.6A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
 0.82A 4xp4A-4xnuA:
62.8		 4xp4A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		7 / 11 PHE A  43
ASP A  46
ALA A  48
TYR A 124
GLY A 322
SER A 421
GLY A 424
 41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
NA  A 601 ( 4.6A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
 0.88A 4xp4A-4xnuA:
62.8		 4xp4A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		10 / 11 PHE A  43
ASP A  46
ALA A  48
VAL A 120
ASP A 121
TYR A 123
TYR A 124
GLY A 322
SER A 421
GLY A 425
 41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
NA  A 601 ( 4.6A)
41U  A 605 (-4.2A)
41U  A 605 ( 4.2A)
None
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.61A 4xp4A-4xnuA:
62.8		 4xp4A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP6_A_B40A601_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		4 / 5 ASP A  46
VAL A 120
ASP A 121
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 4.2A)
41U  A 605 ( 3.7A)
 0.23A 4xp6A-4xnuA:
62.3		 4xp6A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP6_A_B40A601_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		4 / 5 ASP A  46
VAL A 120
PHE A 325
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
41U  A 605 ( 4.7A)
41U  A 605 ( 3.7A)
 0.80A 4xp6A-4xnuA:
62.3		 4xp6A-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP9_C_1WEC706_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		4 / 4 PHE A  43
ASP A  46
GLY A 322
SER A 421
 41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
 0.38A 4xp9C-4xnuA:
62.6		 4xp9C-4xnuA:
98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XPB_A_COCA702_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		5 / 10 PHE A  43
ASP A  46
GLY A 322
PHE A 325
SER A 421
 41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
 0.85A 4xpbA-4xnuA:
61.8		 4xpbA-4xnuA:
99.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XPB_A_COCA702_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 10 PHE A  43
ASP A  46
TYR A 124
GLY A 322
SER A 421
GLY A 424
 41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
 0.93A 4xpbA-4xnuA:
61.8		 4xpbA-4xnuA:
99.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XPB_A_COCA702_1
(TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		8 / 10 PHE A  43
ASP A  46
VAL A 120
TYR A 123
TYR A 124
GLY A 322
SER A 421
GLY A 425
 41U  A 605 (-4.2A)
41U  A 605 ( 3.3A)
41U  A 605 (-4.2A)
None
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.36A 4xpbA-4xnuA:
61.8		 4xpbA-4xnuA:
99.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		4 / 7 PHE A 325
ILE A 116
PHE A 319
THR A 535
 41U  A 605 ( 4.7A)
None
None
None
 0.89A 4zdzA-4xnuA:
undetectable		 4zdzA-4xnuA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		4 / 7 PHE A 325
ILE A 116
PHE A 319
THR A 535
 41U  A 605 ( 4.7A)
None
None
None
 0.92A 4ze3A-4xnuA:
undetectable		 4ze3A-4xnuA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		4 / 8 PHE A 325
ILE A 116
PHE A 319
THR A 535
 41U  A 605 ( 4.7A)
None
None
None
 0.92A 5esjA-4xnuA:
undetectable		 5esjA-4xnuA:
23.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 10 ASP A  46
ALA A 117
TYR A 124
GLY A 322
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 ( 3.7A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.57A 5i6xA-4xnuA:
55.0		 5i6xA-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		5 / 10 ASP A  46
TYR A 124
GLY A 322
SER A 421
GLY A 424
 41U  A 605 ( 3.3A)
41U  A 605 ( 3.8A)
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
None
 0.77A 5i6xA-4xnuA:
55.0		 5i6xA-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 12 ASP A  46
TYR A 123
PHE A 319
GLY A 322
GLY A 425
GLY A 480
 41U  A 605 ( 3.3A)
None
None
41U  A 605 ( 4.1A)
41U  A 605 ( 3.7A)
None
 0.36A 5i71A-4xnuA:
53.8		 5i71A-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 12 ASP A  46
TYR A 123
PHE A 319
GLY A 322
GLY A 425
GLY A 480
 41U  A 605 ( 3.3A)
None
None
41U  A 605 ( 4.1A)
41U  A 605 ( 3.7A)
None
 0.42A 5i73A-4xnuA:
54.4		 5i73A-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 12 ASP A  46
TYR A 123
GLY A 322
SER A 421
GLY A 425
GLY A 480
 41U  A 605 ( 3.3A)
None
41U  A 605 ( 4.1A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
None
 0.31A 5i75A-4xnuA:
54.5		 5i75A-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		7 / 9 ASP A  46
ALA A 117
PHE A 319
GLY A 322
PHE A 325
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 ( 3.7A)
None
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.70A 6awoA-4xnuA:
54.2		 6awoA-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		7 / 9 ASP A  46
ASN A  49
SER A 320
PHE A 325
SER A 421
SER A 422
GLY A 425
 41U  A 605 ( 3.3A)
NA  A 601 (-2.9A)
NA  A 601 (-2.4A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
None
41U  A 605 ( 3.7A)
 0.48A 6awpA-4xnuA:
54.2		 6awpA-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		6 / 9 ASP A  46
ASN A  49
SER A 320
SER A 421
SER A 422
GLY A 424
 41U  A 605 ( 3.3A)
NA  A 601 (-2.9A)
NA  A 601 (-2.4A)
NA  A 602 ( 2.4A)
None
None
 0.86A 6awpA-4xnuA:
54.2		 6awpA-4xnuA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER
(Drosophila
melanogaster) 		7 / 9 ASP A  46
ALA A 117
PHE A 319
GLY A 322
PHE A 325
SER A 421
GLY A 425
 41U  A 605 ( 3.3A)
41U  A 605 ( 3.7A)
None
41U  A 605 ( 4.1A)
41U  A 605 ( 4.7A)
NA  A 602 ( 2.4A)
41U  A 605 ( 3.7A)
 0.69A 6awqA-4xnuA:
54.2		 6awqA-4xnuA:
53.25