SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '40M'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.52A 1iepA-4xcuA:
31.5		 1iepA-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
GLY A 556
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 ( 3.7A)
40M  A1002 (-3.0A)
 0.70A 1iepB-4xcuA:
31.3		 1iepB-4xcuA:
38.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 9 LEU A 473
GLY A 474
VAL A 481
ALA A 501
ALA A 553
LEU A 619
 40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.5A)
 0.61A 1muoA-4xcuA:
8.4		 1muoA-4xcuA:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-3.0A)
 0.63A 1opjA-4xcuA:
31.0		 1opjA-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.51A 1opjA-4xcuA:
31.0		 1opjA-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
GLY A 556
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 ( 3.7A)
40M  A1002 (-3.0A)
 0.67A 1opjB-4xcuA:
31.0		 1opjB-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		5 / 12 VAL A 481
ALA A 501
GLU A 520
LEU A 603
HIS A 610
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
None
 0.45A 1uwjA-4xcuA:
27.0		 1uwjA-4xcuA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		5 / 12 VAL A 481
ALA A 501
GLU A 520
LEU A 603
HIS A 610
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
None
 0.45A 1uwjB-4xcuA:
27.2		 1uwjB-4xcuA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 9 LEU A 473
VAL A 481
ALA A 501
ALA A 553
GLY A 556
LEU A 619
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
 0.74A 1xbbA-4xcuA:
31.1		 1xbbA-4xcuA:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.70A 2hyyA-4xcuA:
31.2		 2hyyA-4xcuA:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.78A 2hyyB-4xcuA:
31.5		 2hyyB-4xcuA:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 481
ALA A 501
GLU A 520
ILE A 527
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.74A 2hyyC-4xcuA:
31.4		 2hyyC-4xcuA:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		4 / 6 LEU A 473
LYS A 503
VAL A 523
MET A 524
 40M  A1002 ( 4.6A)
40M  A1002 (-4.0A)
None
40M  A1002 (-3.8A)
 0.80A 2hyyC-4xcuA:
31.4		 2hyyC-4xcuA:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.72A 2hyyD-4xcuA:
31.4		 2hyyD-4xcuA:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 12 LEU A 473
GLY A 474
VAL A 481
LYS A 503
GLU A 520
VAL A 550
 40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.5A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
 0.52A 2ivuA-4xcuA:
33.3		 2ivuA-4xcuA:
52.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.78A 2oiqA-4xcuA:
30.4		 2oiqA-4xcuA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 LEU A 473
GLY A 474
ALA A 501
LYS A 503
VAL A 550
GLY A 556
LEU A 619
 40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-4.7A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
 0.59A 3c7qA-4xcuA:
34.8		 3c7qA-4xcuA:
52.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 ALA A 501
GLU A 520
VAL A 523
MET A 524
GLY A 556
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 (-3.8A)
40M  A1002 ( 3.7A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.62A 3cs9A-4xcuA:
31.6		 3cs9A-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 12 ALA A 501
GLU A 520
VAL A 523
MET A 524
ILE A 527
HIS A 610
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 (-3.8A)
None
None
 0.57A 3cs9A-4xcuA:
31.6		 3cs9A-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 12 ALA A 501
GLU A 520
MET A 524
GLY A 556
HIS A 610
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 ( 3.7A)
None
40M  A1002 (-3.0A)
 0.54A 3cs9B-4xcuA:
31.4		 3cs9B-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 ALA A 501
GLU A 520
VAL A 523
MET A 524
ILE A 527
GLY A 556
HIS A 610
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 (-3.8A)
None
40M  A1002 ( 3.7A)
None
 0.65A 3cs9B-4xcuA:
31.4		 3cs9B-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 ALA A 501
GLU A 520
VAL A 523
MET A 524
ILE A 527
HIS A 610
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 (-3.8A)
None
None
40M  A1002 (-3.0A)
 0.63A 3cs9C-4xcuA:
30.8		 3cs9C-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 ALA A 501
GLU A 520
VAL A 523
MET A 524
GLY A 556
HIS A 610
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 (-3.8A)
40M  A1002 ( 3.7A)
None
40M  A1002 (-3.0A)
 0.58A 3cs9D-4xcuA:
30.4		 3cs9D-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 12 ALA A 501
GLU A 520
VAL A 523
MET A 524
ILE A 527
HIS A 610
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 (-3.8A)
None
None
 0.59A 3cs9D-4xcuA:
30.4		 3cs9D-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		4 / 6 LEU A 473
VAL A 481
LYS A 503
LEU A 619
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
 0.61A 3cs9D-4xcuA:
30.4		 3cs9D-4xcuA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.63A 3gvuA-4xcuA:
31.2		 3gvuA-4xcuA:
39.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 12 ALA A 501
GLU A 520
MET A 524
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.54A 3ik3A-4xcuA:
31.1		 3ik3A-4xcuA:
39.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 12 ALA A 501
GLU A 520
MET A 524
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.54A 3ik3B-4xcuA:
25.7		 3ik3B-4xcuA:
39.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.62A 3k5vA-4xcuA:
31.0		 3k5vA-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.67A 3k5vB-4xcuA:
30.7		 3k5vB-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.70A 3ms9A-4xcuA:
30.7		 3ms9A-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		9 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.68A 3ms9B-4xcuA:
30.9		 3ms9B-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.73A 3mssA-4xcuA:
30.9		 3mssA-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.54A 3mssB-4xcuA:
30.9		 3mssB-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.68A 3mssB-4xcuA:
30.9		 3mssB-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.74A 3mssC-4xcuA:
30.9		 3mssC-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
ALA A 501
GLU A 520
MET A 524
ILE A 527
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.70A 3mssD-4xcuA:
30.9		 3mssD-4xcuA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 481
ALA A 501
LYS A 503
GLU A 520
VAL A 523
MET A 524
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
None
40M  A1002 (-3.8A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.78A 3oezB-4xcuA:
24.8		 3oezB-4xcuA:
39.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 12 GLY A 474
VAL A 481
ALA A 501
LYS A 503
ILE A 534
ASP A 630
 None
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
 1.06A 3ohtA-4xcuA:
5.1		 3ohtA-4xcuA:
25.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 12 ALA A 501
GLU A 520
MET A 524
GLY A 556
HIS A 610
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 ( 3.7A)
None
40M  A1002 (-3.0A)
 0.44A 3oxzA-4xcuA:
31.0		 3oxzA-4xcuA:
40.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.62A 3pyyA-4xcuA:
31.9		 3pyyA-4xcuA:
39.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.51A 3pyyB-4xcuA:
31.0		 3pyyB-4xcuA:
39.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
ALA A 501
GLU A 520
MET A 524
GLY A 556
LEU A 619
ALA A 629
ASP A 630
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
40M  A1002 (-4.5A)
 0.79A 3qlgB-4xcuA:
8.5		 3qlgB-4xcuA:
39.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
LEU A 619
ALA A 629
ASP A 630
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
40M  A1002 (-4.5A)
 0.73A 3qlgB-4xcuA:
8.5		 3qlgB-4xcuA:
39.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 481
ALA A 501
GLU A 520
ILE A 534
ALA A 553
LEU A 603
HIS A 610
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
None
None
40M  A1002 (-3.0A)
 0.80A 3rgfA-4xcuA:
16.7		 3rgfA-4xcuA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 12 LEU A 473
GLY A 474
ALA A 501
GLU A 520
VAL A 550
PHE A 631
 40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
40M  A1002 ( 4.2A)
 1.00A 3wzdA-4xcuA:
34.8		 3wzdA-4xcuA:
51.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
VAL A 550
GLY A 556
LEU A 633
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
40M  A1002 ( 3.7A)
None
 0.75A 3wzdA-4xcuA:
34.8		 3wzdA-4xcuA:
51.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
VAL A 550
GLY A 556
PHE A 631
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
40M  A1002 ( 3.7A)
40M  A1002 ( 4.2A)
 0.66A 3wzdA-4xcuA:
34.8		 3wzdA-4xcuA:
51.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 LEU A 473
ALA A 501
GLU A 520
ILE A 527
VAL A 550
LEU A 603
HIS A 610
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
None
40M  A1002 (-4.7A)
None
None
 0.55A 3wzeA-4xcuA:
33.8		 3wzeA-4xcuA:
51.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 LEU A 473
ALA A 501
GLU A 520
VAL A 550
GLY A 556
LEU A 603
HIS A 610
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
40M  A1002 ( 3.7A)
None
None
 0.53A 3wzeA-4xcuA:
33.8		 3wzeA-4xcuA:
51.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
ALA A 501
LYS A 503
GLU A 520
LEU A 603
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
None
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.69A 3zosA-4xcuA:
29.7		 3zosA-4xcuA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 ALA A 501
GLU A 520
ILE A 534
LEU A 603
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.0A)
None
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.56A 3zosB-4xcuA:
29.5		 3zosB-4xcuA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 ALA A 501
LYS A 503
GLU A 520
ILE A 534
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-4.0A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.71A 3zosB-4xcuA:
29.5		 3zosB-4xcuA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
VAL A 481
ALA A 501
LYS A 503
GLU A 520
VAL A 550
GLY A 556
LEU A 619
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
 0.74A 4ag8A-4xcuA:
27.8		 4ag8A-4xcuA:
51.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 12 LEU A 473
VAL A 481
ALA A 501
LYS A 503
GLU A 520
VAL A 550
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
 0.59A 4agcA-4xcuA:
33.7		 4agcA-4xcuA:
47.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
VAL A 550
GLY A 556
LEU A 603
HIS A 610
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
40M  A1002 ( 3.7A)
None
None
 0.61A 4asdA-4xcuA:
33.8		 4asdA-4xcuA:
47.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 534
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.92A 4bkjA-4xcuA:
25.7		 4bkjA-4xcuA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 534
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.86A 4bkjB-4xcuA:
29.6		 4bkjB-4xcuA:
38.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 ALA A 501
LYS A 503
GLU A 520
ILE A 533
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
None
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.73A 4c8bB-4xcuA:
26.0		 4c8bB-4xcuA:
24.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 481
ALA A 501
GLU A 520
MET A 524
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.56A 4csvA-4xcuA:
31.2		 4csvA-4xcuA:
42.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 11 LEU A 473
GLY A 474
VAL A 481
ALA A 501
LYS A 503
ASN A 617
LEU A 619
ASP A 630
 40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
None
40M  A1002 (-4.5A)
40M  A1002 (-4.5A)
 0.92A 4o0sA-4xcuA:
24.4		 4o0sA-4xcuA:
28.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 ALA A 501
GLU A 520
MET A 524
VAL A 550
CYH A 552
LEU A 603
CYH A 608
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.7A)
40M  A1002 (-1.8A)
None
None
40M  A1002 (-3.0A)
 0.32A 4qrcA-4xcuA:
39.0		 4qrcA-4xcuA:
90.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 12 ALA A 501
GLU A 520
MET A 524
VAL A 550
LEU A 603
LEU A 633
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.7A)
None
None
 1.30A 4qrcA-4xcuA:
39.0		 4qrcA-4xcuA:
90.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
CYH A 608
LEU A 619
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
 0.64A 4r7iA-4xcuA:
27.2		 4r7iA-4xcuA:
43.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
VAL A 481
ALA A 501
LYS A 503
GLY A 556
ASN A 617
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 ( 3.7A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.74A 4twpA-4xcuA:
31.7		 4twpA-4xcuA:
40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
VAL A 481
ALA A 501
LYS A 503
GLY A 556
ASN A 617
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 ( 3.7A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.83A 4twpB-4xcuA:
31.9		 4twpB-4xcuA:
40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		10 / 12 ALA A 501
GLU A 520
MET A 524
ILE A 527
VAL A 550
ALA A 553
CYH A 608
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
None
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.69A 4tyjA-4xcuA:
36.2		 4tyjA-4xcuA:
94.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		5 / 6 LEU A 473
VAL A 481
ILE A 533
ARG A 611
ILE A 628
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
None
None
None
 0.72A 4tyjA-4xcuA:
36.2		 4tyjA-4xcuA:
94.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 10 LEU A 473
GLU A 520
ILE A 533
VAL A 548
ARG A 611
ILE A 628
 40M  A1002 ( 4.6A)
40M  A1002 (-3.7A)
None
40M  A1002 (-4.6A)
None
None
 0.76A 4u0iA-4xcuA:
33.4		 4u0iA-4xcuA:
48.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 10 LEU A 473
VAL A 481
GLU A 520
ILE A 533
VAL A 548
ILE A 628
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 (-3.7A)
None
40M  A1002 (-4.6A)
None
 0.67A 4u0iA-4xcuA:
33.4		 4u0iA-4xcuA:
48.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		9 / 12 LEU A 473
ALA A 501
GLU A 520
VAL A 550
LEU A 603
CYH A 608
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
None
None
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.66A 4uxqA-4xcuA:
38.5		 4uxqA-4xcuA:
94.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 7 VAL A 481
LYS A 503
MET A 524
ILE A 534
ALA A 553
ILE A 628
 40M  A1002 ( 4.5A)
40M  A1002 (-4.0A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
None
 0.81A 4uxqA-4xcuA:
38.5		 4uxqA-4xcuA:
94.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		9 / 12 ALA A 501
GLU A 520
MET A 524
ILE A 527
VAL A 550
ALA A 553
LEU A 603
HIS A 610
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
None
None
40M  A1002 (-3.0A)
 0.45A 4v01A-4xcuA:
37.9		 4v01A-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 9 LEU A 473
VAL A 481
ILE A 534
ARG A 611
LEU A 619
ILE A 628
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 (-4.0A)
None
40M  A1002 (-4.5A)
None
 0.78A 4v01A-4xcuA:
37.9		 4v01A-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		9 / 12 ALA A 501
GLU A 520
MET A 524
VAL A 550
ALA A 553
LEU A 603
CYH A 608
HIS A 610
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
None
None
None
40M  A1002 (-3.0A)
 0.36A 4v01B-4xcuA:
37.8		 4v01B-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 9 LEU A 473
VAL A 481
LYS A 503
ILE A 527
ILE A 534
ARG A 611
LEU A 619
ILE A 628
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 (-4.0A)
None
40M  A1002 (-4.0A)
None
40M  A1002 (-4.5A)
None
 0.84A 4v01B-4xcuA:
37.8		 4v01B-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		10 / 12 VAL A 481
ALA A 501
GLU A 520
VAL A 550
ALA A 553
LEU A 603
CYH A 608
HIS A 610
ALA A 629
GLY A 632
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
None
None
None
40M  A1002 (-3.0A)
None
 0.38A 4v04A-4xcuA:
38.9		 4v04A-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		5 / 8 LYS A 503
MET A 524
ILE A 534
LEU A 619
ILE A 628
 40M  A1002 (-4.0A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
None
 0.50A 4v04A-4xcuA:
38.9		 4v04A-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		6 / 10 LEU A 473
MET A 524
ILE A 534
LEU A 619
ILE A 628
LEU A 633
 40M  A1002 ( 4.6A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
None
None
 0.51A 4v04B-4xcuA:
38.7		 4v04B-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 10 LEU A 473
VAL A 481
LYS A 503
MET A 524
ILE A 534
LEU A 619
ILE A 628
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 (-4.0A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
None
 0.62A 4v04B-4xcuA:
38.7		 4v04B-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		9 / 12 ALA A 501
GLU A 520
VAL A 550
ALA A 553
LEU A 603
CYH A 608
HIS A 610
ALA A 629
GLY A 632
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
None
None
None
40M  A1002 (-3.0A)
None
 0.33A 4v04B-4xcuA:
38.7		 4v04B-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 481
ALA A 501
LYS A 503
GLY A 556
ASN A 617
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 ( 3.7A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.93A 4wa9B-4xcuA:
31.5		 4wa9B-4xcuA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 LEU A 473
VAL A 481
ALA A 501
LYS A 503
MET A 524
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.8A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.79A 4xeyA-4xcuA:
32.3		 4xeyA-4xcuA:
33.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
ALA A 501
LYS A 503
GLU A 520
MET A 524
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.78A 4xliA-4xcuA:
31.6		 4xliA-4xcuA:
40.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
ALA A 501
LYS A 503
GLU A 520
MET A 524
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.79A 4xliB-4xcuA:
31.8		 4xliB-4xcuA:
40.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		10 / 12 LEU A 473
VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
ILE A 534
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.78A 5bvwA-4xcuA:
25.8		 5bvwA-4xcuA:
38.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		5 / 12 ALA A 501
ILE A 534
ALA A 553
PHE A 631
GLY A 632
 40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 ( 4.2A)
None
 0.68A 5hesA-4xcuA:
26.4		 5hesA-4xcuA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		5 / 12 VAL A 481
ALA A 501
ILE A 534
ALA A 553
PHE A 631
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 ( 4.2A)
 0.61A 5hesA-4xcuA:
26.4		 5hesA-4xcuA:
30.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		5 / 12 ALA A 501
VAL A 523
MET A 524
HIS A 610
ALA A 629
 40M  A1002 ( 4.1A)
None
40M  A1002 (-3.8A)
None
40M  A1002 (-3.0A)
 0.52A 5mo4A-4xcuA:
26.6		 5mo4A-4xcuA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		5 / 12 VAL A 523
MET A 524
HIS A 610
LEU A 619
ALA A 629
 None
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.60A 5mo4A-4xcuA:
26.6		 5mo4A-4xcuA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		5 / 12 LEU A 473
GLY A 474
VAL A 481
ALA A 501
ALA A 629
 40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.0A)
 0.55A 5xv7A-4xcuA:
21.2		 5xv7A-4xcuA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 LEU A 473
VAL A 481
ALA A 501
LYS A 503
GLU A 520
GLY A 556
LEU A 619
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
 0.82A 5y7zA-4xcuA:
23.0		 5y7zA-4xcuA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 LEU A 473
VAL A 481
ALA A 501
LYS A 503
GLU A 520
GLY A 556
LEU A 619
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
 0.82A 5y7zA-4xcuA:
23.0		 5y7zA-4xcuA:
26.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 LEU A 473
GLY A 474
VAL A 481
ALA A 501
GLU A 520
MET A 524
VAL A 550
ALA A 629
 40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.7A)
40M  A1002 (-3.0A)
 1.00A 5zv2A-4xcuA:
38.4		 5zv2A-4xcuA:
65.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		9 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
VAL A 550
ALA A 553
GLY A 556
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
40M  A1002 ( 3.7A)
40M  A1002 (-3.0A)
 0.52A 5zv2A-4xcuA:
38.4		 5zv2A-4xcuA:
65.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		3 / 3 LYS A 503
LEU A 619
ASP A 630
 40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
40M  A1002 (-4.5A)
 0.60A 5zv2A-4xcuA:
38.4		 5zv2A-4xcuA:
65.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		10 / 12 LEU A 473
VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
VAL A 550
ALA A 553
GLY A 556
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
40M  A1002 ( 3.7A)
40M  A1002 (-3.0A)
 0.55A 5zv2B-4xcuA:
38.0		 5zv2B-4xcuA:
65.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
ILE A 534
GLY A 556
LEU A 619
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
 0.87A 6bsdA-4xcuA:
30.2		 6bsdA-4xcuA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
ILE A 527
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.78A 6hd4A-4xcuA:
30.9		 6hd4A-4xcuA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.73A 6hd4B-4xcuA:
30.5		 6hd4B-4xcuA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
ILE A 527
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-3.0A)
 0.78A 6hd4B-4xcuA:
30.5		 6hd4B-4xcuA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.72A 6hd6A-4xcuA:
30.9		 6hd6A-4xcuA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
LEU A 619
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
 0.73A 6hd6B-4xcuA:
30.4		 6hd6B-4xcuA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens) 		7 / 12 LEU A 473
VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
ILE A 527
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
 0.78A 6hd6B-4xcuA:
30.4		 6hd6B-4xcuA:
18.15