SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3YN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E
(Streptomyces
argillaceus) 		4 / 8 ILE A 322
LEU A 345
LYS A 330
GLY A 331
 None
None
3YN  A 503 (-2.9A)
None
 1.07A 1os6A-4rvhA:
undetectable		 1os6A-4rvhA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E
(Streptomyces
argillaceus) 		3 / 3 SER A 234
HIS A 226
ASP A 220
 None
3YN  A 503 (-4.5A)
None
 0.76A 2oxtA-4rvhA:
6.8		 2oxtA-4rvhA:
22.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E
(Streptomyces
argillaceus) 		7 / 12 TYR A  77
TYR A  79
GLU A 112
ILE A 113
PHE A 155
PHE A 156
ILE A 183
 SAH  A 502 (-4.3A)
3YN  A 503 (-3.4A)
None
SAH  A 502 (-4.7A)
SAH  A 502 (-4.8A)
None
SAH  A 502 (-4.2A)
 0.50A 3ndiA-4rvhA:
54.3		 3ndiA-4rvhA:
39.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E
(Streptomyces
argillaceus) 		5 / 12 GLY A 114
ILE A 134
VAL A 179
HIS A 182
ILE A 183
 SAH  A 502 (-3.5A)
None
SAH  A 502 (-4.2A)
3YN  A 503 (-3.9A)
SAH  A 502 (-4.2A)
 0.70A 4ax8A-4rvhA:
12.6		 4ax8A-4rvhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E
(Streptomyces
argillaceus) 		5 / 12 GLY A 114
ILE A 134
VAL A 179
HIS A 182
ILE A 183
 SAH  A 502 (-3.5A)
None
SAH  A 502 (-4.2A)
3YN  A 503 (-3.9A)
SAH  A 502 (-4.2A)
 0.66A 4azvA-4rvhA:
13.2		 4azvA-4rvhA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E
(Streptomyces
argillaceus) 		4 / 7 ILE A 322
LEU A 345
LYS A 330
GLY A 331
 None
None
3YN  A 503 (-2.9A)
None
 1.06A 4hbfA-4rvhA:
undetectable		 4hbfA-4rvhA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E
(Streptomyces
argillaceus) 		4 / 7 ILE A 322
LEU A 345
LYS A 330
GLY A 331
 None
None
3YN  A 503 (-2.9A)
None
 1.02A 4hc3A-4rvhA:
undetectable		 4hc3A-4rvhA:
10.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E
(Streptomyces
argillaceus) 		12 / 12 TYR A  74
TYR A  77
ILE A 113
GLY A 114
PRO A 136
ALA A 137
PHE A 156
ARG A 177
HIS A 178
VAL A 179
HIS A 182
ILE A 183
 SAH  A 502 (-3.6A)
SAH  A 502 (-4.3A)
SAH  A 502 (-4.7A)
SAH  A 502 (-3.5A)
SAH  A 502 (-4.0A)
SAH  A 502 ( 3.8A)
None
SAH  A 502 (-3.4A)
3YN  A 503 (-4.3A)
SAH  A 502 (-4.2A)
3YN  A 503 (-3.9A)
SAH  A 502 (-4.2A)
 0.10A 4rvdA-4rvhA:
67.3		 4rvdA-4rvhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E
(Streptomyces
argillaceus) 		12 / 12 TYR A  74
THR A  81
ILE A 113
GLY A 114
ASN A 116
PRO A 136
ALA A 137
PHE A 156
ARG A 177
VAL A 179
HIS A 182
ILE A 183
 SAH  A 502 (-3.6A)
SAH  A 502 (-2.8A)
SAH  A 502 (-4.7A)
SAH  A 502 (-3.5A)
SAH  A 502 (-4.0A)
SAH  A 502 (-4.0A)
SAH  A 502 ( 3.8A)
None
SAH  A 502 (-3.4A)
SAH  A 502 (-4.2A)
3YN  A 503 (-3.9A)
SAH  A 502 (-4.2A)
 0.12A 4rvgA-4rvhA:
68.7		 4rvgA-4rvhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E
(Streptomyces
argillaceus) 		4 / 7 HIS A  90
HIS A 178
VAL A 254
SER A 258
 None
3YN  A 503 (-4.3A)
None
None
 1.03A 5m8rA-4rvhA:
undetectable		 5m8rA-4rvhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E
(Streptomyces
argillaceus) 		4 / 8 HIS A  90
HIS A 178
VAL A 254
SER A 258
 None
3YN  A 503 (-4.3A)
None
None
 1.02A 5m8rB-4rvhA:
undetectable		 5m8rB-4rvhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E
(Streptomyces
argillaceus) 		5 / 12 GLY A 257
GLY A 256
GLY A 176
HIS A 226
GLU A 112
 None
None
None
3YN  A 503 (-4.5A)
None
 0.99A 6gngB-4rvhA:
2.8		 6gngB-4rvhA:
22.52