SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3XR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.01A 1a4gA-4x6kA:
21.1		 1a4gA-4x6kA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.58A 1a4gA-4x6kA:
21.1		 1a4gA-4x6kA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.00A 1a4gB-4x6kA:
21.2		 1a4gB-4x6kA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.46A 1a4gB-4x6kA:
21.2		 1a4gB-4x6kA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.97A 1nncA-4x6kA:
18.1		 1nncA-4x6kA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 10 ARG A 257
TYR A 525
GLU A 559
ARG A 575
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-4.2A)
 0.99A 1v3eA-4x6kA:
21.3		 1v3eA-4x6kA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.99A 2cmlA-4x6kA:
4.5		 2cmlA-4x6kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.60A 2cmlA-4x6kA:
4.5		 2cmlA-4x6kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.06A 2cmlB-4x6kA:
4.2		 2cmlB-4x6kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.61A 2cmlB-4x6kA:
4.2		 2cmlB-4x6kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.05A 2cmlC-4x6kA:
18.4		 2cmlC-4x6kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.65A 2cmlC-4x6kA:
18.4		 2cmlC-4x6kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.08A 2cmlD-4x6kA:
18.3		 2cmlD-4x6kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.63A 2cmlD-4x6kA:
18.3		 2cmlD-4x6kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
ARG A 276
GLU A 559
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-3.4A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.84A 2f0zA-4x6kA:
36.9		 2f0zA-4x6kA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
TYR A 525
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.52A 2f0zA-4x6kA:
36.9		 2f0zA-4x6kA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		8 / 12 ARG A 257
ILE A 258
ARG A 276
TYR A 525
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 (-3.4A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.69A 2f10A-4x6kA:
36.3		 2f10A-4x6kA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.18A 2htqA-4x6kA:
18.8		 2htqA-4x6kA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		3 / 3 ARG A 637
ASN A 707
THR A 280
 3XR  A 802 (-3.0A)
None
None
 0.72A 2q63A-4x6kA:
undetectable		 2q63A-4x6kA:
11.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
ILE A 258
ASP A 274
ILE A 287
ARG A 637
 3XR  A 802 (-3.0A)
None
None
None
3XR  A 802 (-3.0A)
 1.46A 2ya7A-4x6kA:
40.9		 2ya7A-4x6kA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		10 / 12 ARG A 257
ILE A 258
ASP A 274
ILE A 338
ASP A 339
ASP A 356
TYR A 525
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
None
3XR  A 802 (-4.2A)
3XR  A 802 (-2.8A)
3XR  A 802 (-4.6A)
None
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.36A 2ya7A-4x6kA:
40.9		 2ya7A-4x6kA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
ILE A 258
ASP A 274
ILE A 287
ARG A 637
 3XR  A 802 (-3.0A)
None
None
None
3XR  A 802 (-3.0A)
 1.43A 2ya7B-4x6kA:
40.6		 2ya7B-4x6kA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		10 / 12 ARG A 257
ILE A 258
ASP A 274
ILE A 338
ASP A 339
ASP A 356
TYR A 525
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
None
3XR  A 802 (-4.2A)
3XR  A 802 (-2.8A)
3XR  A 802 (-4.6A)
None
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.34A 2ya7B-4x6kA:
40.6		 2ya7B-4x6kA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
ILE A 258
ASP A 274
ILE A 287
ARG A 637
 3XR  A 802 (-3.0A)
None
None
None
3XR  A 802 (-3.0A)
 1.43A 2ya7C-4x6kA:
41.0		 2ya7C-4x6kA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		10 / 12 ARG A 257
ILE A 258
ASP A 274
ILE A 338
ASP A 339
ASP A 356
TYR A 525
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
None
3XR  A 802 (-4.2A)
3XR  A 802 (-2.8A)
3XR  A 802 (-4.6A)
None
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.35A 2ya7C-4x6kA:
41.0		 2ya7C-4x6kA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
ILE A 258
ASP A 274
ILE A 287
ARG A 637
 3XR  A 802 (-3.0A)
None
None
None
3XR  A 802 (-3.0A)
 1.43A 2ya7D-4x6kA:
40.8		 2ya7D-4x6kA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		10 / 12 ARG A 257
ILE A 258
ASP A 274
ILE A 338
ASP A 339
ASP A 356
TYR A 525
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
None
3XR  A 802 (-4.2A)
3XR  A 802 (-2.8A)
3XR  A 802 (-4.6A)
None
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.35A 2ya7D-4x6kA:
40.8		 2ya7D-4x6kA:
31.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.71A 3b7eA-4x6kA:
18.6		 3b7eA-4x6kA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.70A 3b7eB-4x6kA:
18.7		 3b7eB-4x6kA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.51A 3ckzA-4x6kA:
12.3		 3ckzA-4x6kA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
 0.67A 3k37B-4x6kA:
21.3		 3k37B-4x6kA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-4.2A)
 0.54A 3k39B-4x6kA:
21.2		 3k39B-4x6kA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.08A 3k39N-4x6kA:
4.7		 3k39N-4x6kA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.08A 3k39P-4x6kA:
21.2		 3k39P-4x6kA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.08A 3sanA-4x6kA:
18.8		 3sanA-4x6kA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.07A 3sanB-4x6kA:
10.5		 3sanB-4x6kA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.66A 3ti5A-4x6kA:
10.9		 3ti5A-4x6kA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.66A 3ti5B-4x6kA:
10.1		 3ti5B-4x6kA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.06A 3ticA-4x6kA:
7.7		 3ticA-4x6kA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.60A 3ticA-4x6kA:
7.7		 3ticA-4x6kA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.06A 3ticB-4x6kA:
18.5		 3ticB-4x6kA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.64A 3ticB-4x6kA:
18.5		 3ticB-4x6kA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.07A 3ticC-4x6kA:
2.7		 3ticC-4x6kA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.62A 3ticC-4x6kA:
2.7		 3ticC-4x6kA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.06A 3ticD-4x6kA:
18.5		 3ticD-4x6kA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.62A 3ticD-4x6kA:
18.5		 3ticD-4x6kA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.69A 4b7nA-4x6kA:
11.9		 4b7nA-4x6kA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.73A 4b7qA-4x6kA:
18.7		 4b7qA-4x6kA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.72A 4b7qB-4x6kA:
8.3		 4b7qB-4x6kA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.68A 4b7qC-4x6kA:
11.9		 4b7qC-4x6kA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.74A 4b7qD-4x6kA:
12.1		 4b7qD-4x6kA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.06A 4cpnA-4x6kA:
21.2		 4cpnA-4x6kA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.66A 4cpnA-4x6kA:
21.2		 4cpnA-4x6kA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.02A 4cpnB-4x6kA:
21.3		 4cpnB-4x6kA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.64A 4cpnB-4x6kA:
21.3		 4cpnB-4x6kA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.11A 4cpzA-4x6kA:
21.2		 4cpzA-4x6kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.49A 4cpzA-4x6kA:
21.2		 4cpzA-4x6kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.05A 4cpzB-4x6kA:
4.1		 4cpzB-4x6kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.45A 4cpzB-4x6kA:
4.1		 4cpzB-4x6kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.08A 4cpzC-4x6kA:
21.3		 4cpzC-4x6kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.63A 4cpzC-4x6kA:
21.3		 4cpzC-4x6kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.12A 4cpzD-4x6kA:
21.3		 4cpzD-4x6kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.07A 4cpzE-4x6kA:
21.2		 4cpzE-4x6kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.66A 4cpzE-4x6kA:
21.2		 4cpzE-4x6kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.12A 4cpzF-4x6kA:
21.2		 4cpzF-4x6kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.67A 4cpzF-4x6kA:
21.2		 4cpzF-4x6kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.17A 4cpzG-4x6kA:
21.3		 4cpzG-4x6kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.62A 4cpzG-4x6kA:
21.3		 4cpzG-4x6kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.17A 4cpzH-4x6kA:
21.2		 4cpzH-4x6kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.66A 4cpzH-4x6kA:
21.2		 4cpzH-4x6kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		4 / 8 ASP A 282
ASP A 274
GLU A 693
ASP A 356
 3XR  A 802 (-2.5A)
None
None
3XR  A 802 (-4.6A)
 1.16A 4feuF-4x6kA:
undetectable		 4feuF-4x6kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		4 / 8 ASP A 282
ASP A 274
GLU A 693
ASP A 356
 3XR  A 802 (-2.5A)
None
None
3XR  A 802 (-4.6A)
 1.17A 4gkiC-4x6kA:
undetectable		 4gkiC-4x6kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
ALA A 556
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.99A 4i00A-4x6kA:
18.5		 4i00A-4x6kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.60A 4i00A-4x6kA:
18.5		 4i00A-4x6kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		3 / 3 TYR A 677
ARG A 637
SER A 676
 3XR  A 802 (-4.2A)
3XR  A 802 (-3.0A)
None
 1.12A 4lf7I-4x6kA:
undetectable
4lf7J-4x6kA:
undetectable		 4lf7I-4x6kA:
14.47
4lf7J-4x6kA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		3 / 3 TYR A 677
ARG A 637
SER A 676
 3XR  A 802 (-4.2A)
3XR  A 802 (-3.0A)
None
 1.12A 4lf8I-4x6kA:
undetectable
4lf8J-4x6kA:
undetectable		 4lf8I-4x6kA:
14.47
4lf8J-4x6kA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.96A 4mwrA-4x6kA:
2.7		 4mwrA-4x6kA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.91A 4mwxA-4x6kA:
7.6		 4mwxA-4x6kA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.63A 4mwxA-4x6kA:
7.6		 4mwxA-4x6kA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		3 / 3 ARG A 257
ASP A 282
ARG A 637
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 (-3.0A)
 0.43A 4mx0A-4x6kA:
18.2		 4mx0A-4x6kA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 11 ALA A 556
THR A 557
ALA A 558
GLY A 606
GLY A 579
SER A 578
 None
3XR  A 802 ( 4.5A)
None
None
None
None
 1.18A 4qvwK-4x6kA:
undetectable
4qvwL-4x6kA:
undetectable		 4qvwK-4x6kA:
20.30
4qvwL-4x6kA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 11 ALA A 556
THR A 557
ALA A 558
GLY A 606
GLY A 579
SER A 578
 None
3XR  A 802 ( 4.5A)
None
None
None
None
 1.17A 4qvwY-4x6kA:
undetectable
4qvwZ-4x6kA:
undetectable		 4qvwY-4x6kA:
20.30
4qvwZ-4x6kA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 1.09A 4wa5A-4x6kA:
18.8		 4wa5A-4x6kA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.68A 4wa5A-4x6kA:
18.8		 4wa5A-4x6kA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		3 / 3 ASP A 696
ARG A 637
TYR A 695
 None
3XR  A 802 (-3.0A)
None
 0.98A 5a7mA-4x6kA:
undetectable		 5a7mA-4x6kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		3 / 3 ASP A 696
ARG A 637
TYR A 695
 None
3XR  A 802 (-3.0A)
None
 0.97A 5a7mB-4x6kA:
undetectable		 5a7mB-4x6kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ALA A 556
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.96A 5l17A-4x6kA:
7.8		 5l17A-4x6kA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		6 / 12 ARG A 257
ASP A 282
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.60A 5l17A-4x6kA:
7.8		 5l17A-4x6kA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		4 / 6 SER A 678
ARG A 257
GLU A 693
TYR A 677
 None
3XR  A 802 (-3.0A)
None
3XR  A 802 (-4.2A)
 1.16A 5x7pA-4x6kA:
undetectable		 5x7pA-4x6kA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		4 / 6 SER A 678
ARG A 257
GLU A 693
TYR A 677
 None
3XR  A 802 (-3.0A)
None
3XR  A 802 (-4.2A)
 1.21A 5x7pB-4x6kA:
undetectable		 5x7pB-4x6kA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		4 / 6 SER A 678
ARG A 257
GLU A 693
TYR A 677
 None
3XR  A 802 (-3.0A)
None
3XR  A 802 (-4.2A)
 1.19A 5x7qA-4x6kA:
undetectable		 5x7qA-4x6kA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		4 / 6 SER A 678
ARG A 257
GLU A 693
TYR A 677
 None
3XR  A 802 (-3.0A)
None
3XR  A 802 (-4.2A)
 1.18A 5x7qB-4x6kA:
undetectable		 5x7qB-4x6kA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		4 / 6 SER A 678
ARG A 257
GLU A 693
TYR A 677
 None
3XR  A 802 (-3.0A)
None
3XR  A 802 (-4.2A)
 1.19A 5x7rA-4x6kA:
undetectable		 5x7rA-4x6kA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		7 / 12 ARG A 257
ILE A 258
ARG A 276
GLU A 559
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 (-3.4A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.44A 6ekuA-4x6kA:
35.2		 6ekuA-4x6kA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ILE A 258
ASP A 339
GLU A 559
ARG A 575
TYR A 677
 None
3XR  A 802 (-2.8A)
3XR  A 802 ( 4.7A)
3XR  A 802 (-2.6A)
3XR  A 802 (-4.2A)
 0.82A 6ekuA-4x6kA:
35.2		 6ekuA-4x6kA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
ALA A 556
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
None
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.96A 6hcxA-4x6kA:
5.5		 6hcxA-4x6kA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 4x6k ANHYDROSIALIDASE
([Ruminococcus]
gnavus) 		5 / 12 ARG A 257
ASP A 282
ARG A 575
ARG A 637
TYR A 677
 3XR  A 802 (-3.0A)
3XR  A 802 (-2.5A)
3XR  A 802 (-2.6A)
3XR  A 802 (-3.0A)
3XR  A 802 (-4.2A)
 0.62A 6hcxA-4x6kA:
5.5		 6hcxA-4x6kA:
10.41