SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3V5'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 353
THR A 380
THR A 287
THR A 278
ALA A 257
 3V5  A 502 (-3.7A)
None
None
None
None
 1.41A 1gtnO-4qtfA:
undetectable
1gtnP-4qtfA:
undetectable		 1gtnO-4qtfA:
12.89
1gtnP-4qtfA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 9 GLY A 353
THR A 380
THR A 287
THR A 278
ALA A 257
 3V5  A 502 (-3.7A)
None
None
None
None
 1.41A 1gtnQ-4qtfA:
undetectable
1gtnR-4qtfA:
undetectable		 1gtnQ-4qtfA:
12.89
1gtnR-4qtfA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 11 ASN A 356
MET A 280
GLY A 281
THR A 287
GLY A 332
 None
None
None
None
3V5  A 502 (-3.3A)
 1.11A 1jr1A-4qtfA:
undetectable		 1jr1A-4qtfA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 356
GLY A 281
THR A 287
GLY A 332
 None
None
None
3V5  A 502 (-3.3A)
 0.75A 1jr1B-4qtfA:
undetectable		 1jr1B-4qtfA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 356
GLY A 281
THR A 287
GLY A 332
 None
None
None
3V5  A 502 (-3.3A)
 0.69A 4fo4B-4qtfA:
undetectable		 4fo4B-4qtfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		4 / 8 SER A 351
THR A 278
THR A 380
THR A 287
 3V5  A 502 ( 3.7A)
None
None
None
 1.02A 5l4eA-4qtfA:
undetectable
5l4eB-4qtfA:
undetectable
5l4eC-4qtfA:
undetectable
5l4eD-4qtfA:
undetectable
5l4eE-4qtfA:
undetectable		 5l4eA-4qtfA:
22.81
5l4eB-4qtfA:
22.81
5l4eC-4qtfA:
22.81
5l4eD-4qtfA:
22.81
5l4eE-4qtfA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4qtf L,D-TRANSPEPTIDASE
LDTB
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 332
VAL A 333
THR A 384
GLY A 383
GLY A 382
 3V5  A 502 (-3.3A)
3V5  A 502 ( 4.9A)
None
None
None
 1.22A 6brdB-4qtfA:
undetectable		 6brdB-4qtfA:
11.75