SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3UT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 5ux4 CATHEPSIN D
(Rattus
norvegicus) 		5 / 12 ASP A  33
GLY A  35
ASN A  38
ILE A  76
ILE A 129
 3UT  A 404 (-2.9A)
3UT  A 404 (-3.5A)
None
3UT  A 404 (-4.5A)
None
 0.62A 2q64A-5ux4A:
7.6		 2q64A-5ux4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 5ux4 CATHEPSIN D
(Rattus
norvegicus) 		9 / 12 GLN A  14
VAL A  31
ASP A  33
GLY A  35
SER A  36
PHE A 126
ASP A 226
GLY A 228
SER A 230
 None
3UT  A 404 (-4.5A)
3UT  A 404 (-2.9A)
3UT  A 404 (-3.5A)
3UT  A 404 ( 4.5A)
None
3UT  A 404 (-2.4A)
3UT  A 404 (-3.1A)
3UT  A 404 ( 3.8A)
 0.40A 2v0zC-5ux4A:
46.8		 2v0zC-5ux4A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 5ux4 CATHEPSIN D
(Rattus
norvegicus) 		8 / 12 GLN A  14
ASP A  33
GLY A  35
ALA A 124
ASP A 226
GLY A 228
SER A 230
ILE A 306
 None
3UT  A 404 (-2.9A)
3UT  A 404 (-3.5A)
None
3UT  A 404 (-2.4A)
3UT  A 404 (-3.1A)
3UT  A 404 ( 3.8A)
None
 0.71A 2v0zO-5ux4A:
47.0		 2v0zO-5ux4A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 5ux4 CATHEPSIN D
(Rattus
norvegicus) 		9 / 12 GLN A  14
VAL A  31
ASP A  33
GLY A  35
ALA A 124
PHE A 126
ASP A 226
GLY A 228
SER A 230
 None
3UT  A 404 (-4.5A)
3UT  A 404 (-2.9A)
3UT  A 404 (-3.5A)
None
None
3UT  A 404 (-2.4A)
3UT  A 404 (-3.1A)
3UT  A 404 ( 3.8A)
 0.37A 2v0zO-5ux4A:
47.0		 2v0zO-5ux4A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 5ux4 CATHEPSIN D
(Rattus
norvegicus) 		6 / 12 GLN A  14
ASP A  33
GLY A  35
PHE A 126
ASP A 226
SER A 230
 None
3UT  A 404 (-2.9A)
3UT  A 404 (-3.5A)
None
3UT  A 404 (-2.4A)
3UT  A 404 ( 3.8A)
 0.59A 3d91A-5ux4A:
46.9		 3d91A-5ux4A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 5ux4 CATHEPSIN D
(Rattus
norvegicus) 		5 / 12 GLN A  14
ASP A  33
GLY A  35
ASP A 226
SER A 230
 None
3UT  A 404 (-2.9A)
3UT  A 404 (-3.5A)
3UT  A 404 (-2.4A)
3UT  A 404 ( 3.8A)
 0.43A 3d91B-5ux4A:
46.9		 3d91B-5ux4A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 5ux4 CATHEPSIN D
(Rattus
norvegicus) 		5 / 12 ASP A  33
GLY A  35
ASP A 226
THR A 229
ILE A 315
 3UT  A 404 (-2.9A)
3UT  A 404 (-3.5A)
3UT  A 404 (-2.4A)
3UT  A 404 ( 4.8A)
None
 0.24A 3prsA-5ux4A:
37.5		 3prsA-5ux4A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 5ux4 CATHEPSIN D
(Rattus
norvegicus) 		5 / 12 ASP A  33
GLY A  35
ASP A 226
THR A 229
ILE A 315
 3UT  A 404 (-2.9A)
3UT  A 404 (-3.5A)
3UT  A 404 (-2.4A)
3UT  A 404 ( 4.8A)
None
 0.25A 3q70A-5ux4A:
10.4		 3q70A-5ux4A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 5ux4 CATHEPSIN D
(Rattus
norvegicus) 		6 / 12 ILE A 224
ASP A 226
GLY A 228
ILE A 306
ASP A  33
ILE A 129
 None
3UT  A 404 (-2.4A)
3UT  A 404 (-3.1A)
None
3UT  A 404 (-2.9A)
None
 0.60A 3q70A-5ux4A:
10.4		 3q70A-5ux4A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 5ux4 CATHEPSIN D
(Rattus
norvegicus) 		5 / 12 ILE A 224
ASP A 226
GLY A 228
ASP A  33
ILE A 129
 None
3UT  A 404 (-2.4A)
3UT  A 404 (-3.1A)
3UT  A 404 (-2.9A)
None
 0.64A 3tneA-5ux4A:
36.4		 3tneA-5ux4A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 5ux4 CATHEPSIN D
(Rattus
norvegicus) 		5 / 12 ILE A 224
ASP A 226
GLY A 228
ASP A  33
ILE A 129
 None
3UT  A 404 (-2.4A)
3UT  A 404 (-3.1A)
3UT  A 404 (-2.9A)
None
 0.64A 3tneB-5ux4A:
36.3		 3tneB-5ux4A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 5ux4 CATHEPSIN D
(Rattus
norvegicus) 		4 / 5 PHE A 328
ILE A 321
GLY A 317
THR A 229
 None
None
None
3UT  A 404 ( 4.8A)
 1.02A 4ejjC-5ux4A:
undetectable		 4ejjC-5ux4A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 5ux4 CATHEPSIN D
(Rattus
norvegicus) 		3 / 3 ASP A 226
ASP A  33
ASN A  38
 3UT  A 404 (-2.4A)
3UT  A 404 (-2.9A)
None
 0.57A 4q5mA-5ux4A:
9.9		 4q5mA-5ux4A:
16.75