SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3UK'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 309
LEU A 327
PHE A 252
SER A 223
 3UK  A 900 ( 4.1A)
None
None
None
 1.07A 1wrlB-5oe5A:
undetectable		 1wrlB-5oe5A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 216
THR A 304
GLN A 162
 None
3UK  A 900 (-3.7A)
3UK  A 900 ( 4.8A)
 0.79A 2fk8A-5oe5A:
undetectable		 2fk8A-5oe5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 12 GLY A 337
ILE A 314
GLY A 316
ILE A 317
PRO A 342
 None
None
3UK  A 601 (-4.0A)
3UK  A 601 (-4.0A)
None
 0.91A 2nnkB-4wv3A:
undetectable		 2nnkB-4wv3A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 210
GLY A 300
PHE A 188
PHE A 219
 3UK  A 900 ( 3.2A)
3UK  A 900 (-3.8A)
None
None
 0.87A 2qwxA-5oe5A:
2.1
2qwxB-5oe5A:
2.2		 2qwxA-5oe5A:
19.95
2qwxB-5oe5A:
19.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		6 / 9 PHE A 220
ALA A 293
GLY A 318
HIS A 324
ILE A 325
LYS A 506
 3UK  A 601 (-4.3A)
3UK  A 601 (-3.5A)
3UK  A 601 (-3.5A)
3UK  A 601 (-3.6A)
None
3UK  A 601 (-2.5A)
 0.53A 2v7bA-4wv3A:
59.8		 2v7bA-4wv3A:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		6 / 9 PHE A 209
TYR A 211
ALA A 278
GLY A 279
GLY A 302
HIS A 308
 3UK  A 900 (-4.2A)
3UK  A 900 (-4.0A)
3UK  A 900 ( 2.9A)
3UK  A 900 (-3.2A)
3UK  A 900 (-3.4A)
3UK  A 900 ( 2.8A)
 0.30A 2v7bA-5oe5A:
50.9		 2v7bA-5oe5A:
30.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		6 / 9 PHE A 220
ALA A 293
GLY A 318
HIS A 324
ILE A 325
LYS A 506
 3UK  A 601 (-4.3A)
3UK  A 601 (-3.5A)
3UK  A 601 (-3.5A)
3UK  A 601 (-3.6A)
None
3UK  A 601 (-2.5A)
 0.53A 2v7bB-4wv3A:
59.9		 2v7bB-4wv3A:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		6 / 9 PHE A 209
TYR A 211
ALA A 278
GLY A 279
GLY A 302
HIS A 308
 3UK  A 900 (-4.2A)
3UK  A 900 (-4.0A)
3UK  A 900 ( 2.9A)
3UK  A 900 (-3.2A)
3UK  A 900 (-3.4A)
3UK  A 900 ( 2.8A)
 0.28A 2v7bB-5oe5A:
51.0		 2v7bB-5oe5A:
30.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 393
ASP A 299
SER A 277
GLU A 296
ALA A 318
 None
3UK  A 900 (-2.6A)
None
None
None
 1.15A 3axtA-5oe5A:
undetectable		 3axtA-5oe5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 382
VAL A 353
GLY A 302
PHE A 209
ILE A 301
 3UK  A 900 (-2.0A)
None
3UK  A 900 (-3.4A)
3UK  A 900 (-4.2A)
3UK  A 900 (-4.0A)
 1.14A 3k13A-5oe5A:
undetectable		 3k13A-5oe5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		4 / 5 ILE A 229
THR A 224
THR A 221
PHE A  77
 None
None
3UK  A 601 (-3.8A)
None
 1.17A 3snfA-4wv3A:
undetectable		 3snfA-4wv3A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		4 / 7 PHE A 220
PHE A 222
THR A 320
LYS A 506
 3UK  A 601 (-4.3A)
3UK  A 601 (-4.4A)
3UK  A 601 (-3.6A)
3UK  A 601 (-2.5A)
 0.72A 3vnsA-4wv3A:
45.1		 3vnsA-4wv3A:
26.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		4 / 7 ALA A 293
ILE A 317
GLY A 318
ILE A 325
 3UK  A 601 (-3.5A)
3UK  A 601 (-4.0A)
3UK  A 601 (-3.5A)
None
 0.33A 4eatA-4wv3A:
57.4		 4eatA-4wv3A:
42.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 7 TYR A 211
ALA A 278
GLY A 279
ILE A 301
GLY A 302
 3UK  A 900 (-4.0A)
3UK  A 900 ( 2.9A)
3UK  A 900 (-3.2A)
3UK  A 900 (-4.0A)
3UK  A 900 (-3.4A)
 0.38A 4eatA-5oe5A:
49.3		 4eatA-5oe5A:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 9 ALA A 293
ILE A 317
GLY A 318
HIS A 324
ILE A 325
 3UK  A 601 (-3.5A)
3UK  A 601 (-4.0A)
3UK  A 601 (-3.5A)
3UK  A 601 (-3.6A)
None
 0.30A 4eatB-4wv3A:
57.5		 4eatB-4wv3A:
42.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		6 / 9 TYR A 211
ALA A 278
GLY A 279
ILE A 301
GLY A 302
HIS A 308
 3UK  A 900 (-4.0A)
3UK  A 900 ( 2.9A)
3UK  A 900 (-3.2A)
3UK  A 900 (-4.0A)
3UK  A 900 (-3.4A)
3UK  A 900 ( 2.8A)
 0.34A 4eatB-5oe5A:
49.4		 4eatB-5oe5A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 188
ALA A 278
TYR A 258
VAL A 309
GLY A 300
 None
3UK  A 900 ( 2.9A)
None
3UK  A 900 ( 4.1A)
3UK  A 900 (-3.8A)
 1.24A 4xnxA-5oe5A:
undetectable		 4xnxA-5oe5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 302
TYR A 211
SER A 280
ALA A 303
TYR A 378
 3UK  A 900 (-3.4A)
3UK  A 900 (-4.0A)
PEG  A 901 (-3.8A)
3UK  A 900 (-3.4A)
None
 1.36A 4ymgA-5oe5A:
undetectable		 4ymgA-5oe5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 CYH A 332
ALA A 312
GLY A 300
THR A 323
ASP A 382
 None
None
3UK  A 900 (-3.8A)
3UK  A 900 ( 4.5A)
3UK  A 900 (-2.0A)
 1.37A 5l5zH-5oe5A:
undetectable
5l5zI-5oe5A:
undetectable		 5l5zH-5oe5A:
19.51
5l5zI-5oe5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 CYH A 332
ALA A 312
GLY A 300
THR A 323
ASP A 382
 None
None
3UK  A 900 (-3.8A)
3UK  A 900 ( 4.5A)
3UK  A 900 (-2.0A)
 1.38A 5l5zV-5oe5A:
undetectable
5l5zW-5oe5A:
undetectable		 5l5zV-5oe5A:
19.51
5l5zW-5oe5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 7 PHE A 220
PHE A 222
GLY A 318
HIS A 324
LYS A 506
 3UK  A 601 (-4.3A)
3UK  A 601 (-4.4A)
3UK  A 601 (-3.5A)
3UK  A 601 (-3.6A)
3UK  A 601 (-2.5A)
 0.97A 5n9xA-4wv3A:
45.1		 5n9xA-4wv3A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5oe5 ANTHRANILATE--COA
LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 209
GLY A 279
GLY A 302
HIS A 308
 3UK  A 900 (-4.2A)
3UK  A 900 (-3.2A)
3UK  A 900 (-3.4A)
3UK  A 900 ( 2.8A)
 1.03A 5n9xA-5oe5A:
40.9		 5n9xA-5oe5A:
29.08