SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3SM'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XBB_A_STIA1_1 (TYROSINE-PROTEIN KINASE SYK)	4wov	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (Homo sapiens)	5 / 9	LEU A 595 VAL A 603 GLY A 693 PRO A 694 LEU A 741	3SM A 901 (-3.9A) 3SM A 901 ( 4.4A) 3SM A 901 (-3.0A) 3SM A 901 (-4.3A) 3SM A 901 (-4.1A)	0.44A	1xbbA-4wovA: 28.1	1xbbA-4wovA: 26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G0F_A_B49A9001_1 (MAST/STEM CELL GROWTH FACTOR RECEPTOR)	4wov	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (Homo sapiens)	6 / 11	LEU A 595 VAL A 603 THR A 687 TYR A 689 GLY A 693 LEU A 741	3SM A 901 (-3.9A) 3SM A 901 ( 4.4A) 3SM A 901 ( 4.6A) 3SM A 901 (-3.2A) 3SM A 901 (-3.0A) 3SM A 901 (-4.1A)	0.76A	3g0fA-4wovA: 21.0	3g0fA-4wovA: 25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G0F_B_B49B9001_1 (MAST/STEM CELL GROWTH FACTOR RECEPTOR)	4wov	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (Homo sapiens)	6 / 10	LEU A 595 VAL A 603 THR A 687 TYR A 689 GLY A 693 LEU A 741	3SM A 901 (-3.9A) 3SM A 901 ( 4.4A) 3SM A 901 ( 4.6A) 3SM A 901 (-3.2A) 3SM A 901 (-3.0A) 3SM A 901 (-4.1A)	0.69A	3g0fB-4wovA: 22.5	3g0fB-4wovA: 25.83

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1XBB_A_STIA1_1","TYROSINE-PROTEIN KINASE SYK","4wov","NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2","Homo sapiens",5,"LEU A 595;VAL A 603;GLY A 693;PRO A 694;LEU A 741","3SM A 901 (-3.9A);3SM A 901 ( 4.4A);3SM A 901 (-3.0A);3SM A 901 (-4.3A);3SM A 901 (-4.1A)","0.44A","1xbbA-4wovA:28.1",null],["3G0F_A_B49A9001_1","MAST\/STEM CELL GROWTH FACTOR RECEPTOR","4wov","NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2","Homo sapiens",6,"LEU A 595;VAL A 603;THR A 687;TYR A 689;GLY A 693;LEU A 741","3SM A 901 (-3.9A);3SM A 901 ( 4.4A);3SM A 901 ( 4.6A);3SM A 901 (-3.2A);3SM A 901 (-3.0A);3SM A 901 (-4.1A)","0.76A","3g0fA-4wovA:21.0","1xbbA-4wovA:26.27"],["3G0F_B_B49B9001_1","MAST\/STEM CELL GROWTH FACTOR RECEPTOR","4wov","NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2","Homo sapiens",6,"LEU A 595;VAL A 603;THR A 687;TYR A 689;GLY A 693;LEU A 741","3SM A 901 (-3.9A);3SM A 901 ( 4.4A);3SM A 901 ( 4.6A);3SM A 901 (-3.2A);3SM A 901 (-3.0A);3SM A 901 (-4.1A)","0.69A","3g0fB-4wovA:22.5","3g0fA-4wovA:25.83"]]