SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3SL'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM6_X_BRLX504_1 (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA)	1vr0	PROBABLE 2-PHOSPHOSULFOLACTAT E PHOSPHATASE (Clostridium acetobutylicum)	5 / 12	ILE A 76 GLY A 69 HIS A 201 TYR A 148 LEU A 208	None None 3SL A 300 (-4.6A) 3SL A 300 (-4.8A) None	1.15A	1fm6X-1vr0A: undetectable	1fm6X-1vr0A: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N13_D_AG2D7015_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN)	1vr0	PROBABLE 2-PHOSPHOSULFOLACTAT E PHOSPHATASE (Clostridium acetobutylicum)	4 / 7	LEU A 210 ARG A 29 LEU A 74 GLY A 73	None 3SL A 300 (-3.7A) None 3SL A 300 (-3.6A)	0.86A	1n13D-1vr0A: undetectable 1n13E-1vr0A: undetectable	1n13D-1vr0A: 20.93 1n13E-1vr0A: 10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F93_B_SANB3004_1 (U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE)	1vr0	PROBABLE 2-PHOSPHOSULFOLACTAT E PHOSPHATASE (Clostridium acetobutylicum)	4 / 8	GLU A 70 HIS A 201 ASN A 104 GLY A 146	3SL A 300 (-3.4A) 3SL A 300 (-4.6A) 3SL A 300 (-4.2A) MG A 400 (-4.0A)	1.01A	4f93B-1vr0A: undetectable	4f93B-1vr0A: 9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LMN_A_EUIA503_2 (DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1)	1vr0	PROBABLE 2-PHOSPHOSULFOLACTAT E PHOSPHATASE (Clostridium acetobutylicum)	3 / 3	ASP A 26 VAL A 123 ASN A 83	MG A 400 (-3.1A) None 3SL A 300 (-3.8A)	0.80A	4lmnA-1vr0A: undetectable	4lmnA-1vr0A: 22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OM2_B_DXTB501_1 (ALPHA-1-ANTICHYMOTRY PSIN)	1vr0	PROBABLE 2-PHOSPHOSULFOLACTAT E PHOSPHATASE (Clostridium acetobutylicum)	5 / 9	VAL A 123 PHE A 214 VAL A 196 HIS A 201 ILE A 192	None None None 3SL A 300 (-4.6A) None	1.19A	5om2A-1vr0A: undetectable 5om2B-1vr0A: undetectable	5om2A-1vr0A: 17.77 5om2B-1vr0A: 11.43

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FM6_X_BRLX504_1","PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA","1vr0","PROBABLE 2-PHOSPHOSULFOLACTATE PHOSPHATASE","Clostridium acetobutylicum",5,"ILE A  76;GLY A  69;HIS A 201;TYR A 148;LEU A 208","None;None;3SL A 300 (-4.6A);3SL A 300 (-4.8A);None","1.15A","1fm6X-1vr0A:undetectable",null],["1N13_D_AG2D7015_1","PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN;PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN","1vr0","PROBABLE 2-PHOSPHOSULFOLACTATE PHOSPHATASE","Clostridium acetobutylicum",4,"LEU A 210;ARG A  29;LEU A  74;GLY A  73","None;3SL A 300 (-3.7A);None;3SL A 300 (-3.6A)","0.86A","1n13D-1vr0A:undetectable;1n13E-1vr0A:undetectable","1fm6X-1vr0A:20.14"],["4F93_B_SANB3004_1","U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE","1vr0","PROBABLE 2-PHOSPHOSULFOLACTATE PHOSPHATASE","Clostridium acetobutylicum",4,"GLU A  70;HIS A 201;ASN A 104;GLY A 146","3SL A 300 (-3.4A);3SL A 300 (-4.6A);3SL A 300 (-4.2A); MG A 400 (-4.0A)","1.01A","4f93B-1vr0A:undetectable","1n13D-1vr0A:20.93;1n13E-1vr0A:10.93"],["4LMN_A_EUIA503_2","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","1vr0","PROBABLE 2-PHOSPHOSULFOLACTATE PHOSPHATASE","Clostridium acetobutylicum",3,"ASP A  26;VAL A 123;ASN A  83"," MG A 400 (-3.1A);None;3SL A 300 (-3.8A)","0.80A","4lmnA-1vr0A:undetectable","4f93B-1vr0A:9.77"],["5OM2_B_DXTB501_1","ALPHA-1-ANTICHYMOTRYPSIN;ALPHA-1-ANTICHYMOTRYPSIN","1vr0","PROBABLE 2-PHOSPHOSULFOLACTATE PHOSPHATASE","Clostridium acetobutylicum",5,"VAL A 123;PHE A 214;VAL A 196;HIS A 201;ILE A 192","None;None;None;3SL A 300 (-4.6A);None","1.19A","5om2A-1vr0A:undetectable;5om2B-1vr0A:undetectable","4lmnA-1vr0A:22.48"]]