SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3SK'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4rlq BENZOATE-COENZYME A
LIGASE
(Rhodopseudomonas
palustris) 		5 / 12 HIS A 333
SER A 404
GLU A 330
LEU A 375
ILE A 377
 3SK  A1000 ( 4.1A)
None
None
None
None
 1.24A 1kyvB-4rlqA:
3.7
1kyvC-4rlqA:
3.4		 1kyvB-4rlqA:
15.03
1kyvC-4rlqA:
15.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4rlq BENZOATE-COENZYME A
LIGASE
(Rhodopseudomonas
palustris) 		7 / 9 ALA A 227
TYR A 228
ALA A 302
GLY A 303
GLY A 327
HIS A 333
ILE A 334
 3SK  A1000 (-3.6A)
3SK  A1000 (-4.8A)
3SK  A1000 ( 3.8A)
3SK  A1000 (-3.3A)
3SK  A1000 (-3.6A)
3SK  A1000 ( 4.1A)
None
 0.31A 2v7bA-4rlqA:
62.0		 2v7bA-4rlqA:
61.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4rlq BENZOATE-COENZYME A
LIGASE
(Rhodopseudomonas
palustris) 		7 / 9 ALA A 227
TYR A 228
ALA A 302
GLY A 303
GLY A 327
HIS A 333
ILE A 334
 3SK  A1000 (-3.6A)
3SK  A1000 (-4.8A)
3SK  A1000 ( 3.8A)
3SK  A1000 (-3.3A)
3SK  A1000 (-3.6A)
3SK  A1000 ( 4.1A)
None
 0.32A 2v7bB-4rlqA:
62.0		 2v7bB-4rlqA:
61.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4rlq BENZOATE-COENZYME A
LIGASE
(Rhodopseudomonas
palustris) 		7 / 7 ALA A 227
TYR A 228
ALA A 302
GLY A 303
ILE A 326
GLY A 327
ILE A 334
 3SK  A1000 (-3.6A)
3SK  A1000 (-4.8A)
3SK  A1000 ( 3.8A)
3SK  A1000 (-3.3A)
3SK  A1000 (-4.4A)
3SK  A1000 (-3.6A)
None
 0.10A 4eatA-4rlqA:
73.0		 4eatA-4rlqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 4rlq BENZOATE-COENZYME A
LIGASE
(Rhodopseudomonas
palustris) 		8 / 9 ALA A 227
TYR A 228
ALA A 302
GLY A 303
ILE A 326
GLY A 327
HIS A 333
ILE A 334
 3SK  A1000 (-3.6A)
3SK  A1000 (-4.8A)
3SK  A1000 ( 3.8A)
3SK  A1000 (-3.3A)
3SK  A1000 (-4.4A)
3SK  A1000 (-3.6A)
3SK  A1000 ( 4.1A)
None
 0.16A 4eatB-4rlqA:
71.5		 4eatB-4rlqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4rlq BENZOATE-COENZYME A
LIGASE
(Rhodopseudomonas
palustris) 		4 / 7 SER A 337
HIS A 333
GLY A 327
LEU A 210
 None
3SK  A1000 ( 4.1A)
3SK  A1000 (-3.6A)
None
 1.14A 6btxA-4rlqA:
undetectable		 6btxA-4rlqA:
24.48