SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3S4'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		5 / 9 THR A 275
SER A 155
ILE A 152
ILE A  14
GLY A 106
 3S4  A 402 (-3.7A)
None
None
None
ADP  A 401 (-3.4A)
 1.13A 3cv9A-4rkzA:
undetectable		 3cv9A-4rkzA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		5 / 12 ASN A 248
GLY A 277
SER A 278
ILE A 273
GLY A  15
 None
3S4  A 402 ( 4.8A)
None
None
3S4  A 402 (-3.6A)
 1.21A 4obwC-4rkzA:
undetectable		 4obwC-4rkzA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		4 / 5 SER A  48
ARG A 144
GLY A 148
THR A 153
 ADP  A 401 (-3.4A)
3S4  A 402 (-2.8A)
None
None
 1.19A 5btiA-4rkzA:
1.7
5btiB-4rkzA:
undetectable		 5btiA-4rkzA:
21.92
5btiB-4rkzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		4 / 5 SER A  48
ARG A 144
GLY A 148
THR A 153
 ADP  A 401 (-3.4A)
3S4  A 402 (-2.8A)
None
None
 1.13A 5btiC-4rkzA:
2.1
5btiD-4rkzA:
undetectable		 5btiC-4rkzA:
21.92
5btiD-4rkzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305
(Thermoplasma
acidophilum) 		4 / 5 ARG A 144
ALA A  38
TYR A  39
ILE A 176
 3S4  A 402 (-2.8A)
None
None
None
 1.33A 6f6sA-4rkzA:
undetectable
6f6sB-4rkzA:
0.0		 6f6sA-4rkzA:
14.06
6f6sB-4rkzA:
12.76