SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3R2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RG1_A_SPMA999_1 (TYROSYL-DNA PHOSPHODIESTERASE 1)	4rih	GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE (Streptomyces cyanogenus; Streptomyces fradiae)	3 / 3	TRP A 267 VAL A 268 PRO A 269	3R2 A 401 (-3.5A) 3R2 A 401 (-4.6A) None	0.73A	1rg1A-4rihA: undetectable	1rg1A-4rihA: 19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RH0_A_SPMA999_1 (TYROSYL-DNA PHOSPHODIESTERASE 1)	4rih	GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE (Streptomyces cyanogenus; Streptomyces fradiae)	3 / 3	TRP A 267 VAL A 268 PRO A 269	3R2 A 401 (-3.5A) 3R2 A 401 (-4.6A) None	0.74A	1rh0A-4rihA: undetectable	1rh0A-4rihA: 19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OWX_B_XRAB233_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	4rih	GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE (Streptomyces cyanogenus; Streptomyces fradiae)	5 / 11	VAL A 287 PHE A 170 GLY A 114 GLY A 113 TYR A 131	3R2 A 401 (-3.6A) None None None None	1.23A	3owxA-4rihA: 4.8 3owxB-4rihA: 4.9	3owxA-4rihA: 21.23 3owxB-4rihA: 21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PGH_D_SAMD401_0 (CAFFEIC ACID O-METHYLTRANSFERASE)	4rih	GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE (Streptomyces fradiae; Streptomyces cyanogenus)	5 / 12	GLY A 285 GLY A 286 THR A 138 PHE A 229 ILE A 301	3R2 A 401 (-3.3A) 3R2 A 401 (-3.4A) None None None	1.02A	4pghD-4rihA: 2.9	4pghD-4rihA: 23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QCK_A_ASDA404_1 (3-KETOSTEROID-9-ALPH A-MONOOXYGENASE OXYGENASE SUBUNIT)	4rih	GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE (Streptomyces cyanogenus; Streptomyces fradiae)	5 / 12	HIS A 283 GLN A 299 ALA A 292 LEU A 270 GLY A 218	3R2 A 401 (-4.3A) None None 3R2 A 401 (-3.7A) 3R2 A 401 (-3.5A)	1.26A	4qckA-4rihA: undetectable	4qckA-4rihA: 23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JCN_B_ASCB502_0 (OS09G0567300 PROTEIN)	4rih	GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE (Streptomyces fradiae; Streptomyces cyanogenus)	4 / 6	GLU A 80 GLY A 305 PHE A 223 ARG A 220	None None None 3R2 A 401 (-3.7A)	1.41A	5jcnB-4rihA: 2.7	5jcnB-4rihA: 24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YW0_A_ACTA409_0 (UNCHARACTERIZED PROTEIN KDOO)	4rih	GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE (Streptomyces fradiae; Streptomyces cyanogenus)	3 / 3	ASP A 137 PHE A 88 ARG A 220	3R2 A 401 (-3.6A) None 3R2 A 401 (-3.7A)	0.94A	5yw0A-4rihA: undetectable	5yw0A-4rihA: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_B_EY4B500_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	4rih	GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE (Streptomyces fradiae; Streptomyces cyanogenus)	4 / 6	VAL A 268 TRP A 267 ALA A 247 THR A 216	3R2 A 401 (-4.6A) 3R2 A 401 (-3.5A) 3R2 A 401 (-3.5A) 3R2 A 401 ( 4.8A)	1.04A	6cduB-4rihA: undetectable 6cduC-4rihA: undetectable	6cduB-4rihA: 24.32 6cduC-4rihA: 24.32

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RG1_A_SPMA999_1","TYROSYL-DNA PHOSPHODIESTERASE 1","4rih","GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE","Streptomyces cyanogenus;Streptomyces fradiae",3,"TRP A 267;VAL A 268;PRO A 269","3R2 A 401 (-3.5A);3R2 A 401 (-4.6A);None","0.73A","1rg1A-4rihA:undetectable",null],["1RH0_A_SPMA999_1","TYROSYL-DNA PHOSPHODIESTERASE 1","4rih","GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE","Streptomyces cyanogenus;Streptomyces fradiae",3,"TRP A 267;VAL A 268;PRO A 269","3R2 A 401 (-3.5A);3R2 A 401 (-4.6A);None","0.74A","1rh0A-4rihA:undetectable","1rg1A-4rihA:19.34"],["3OWX_B_XRAB233_1","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE];RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","4rih","GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE","Streptomyces cyanogenus;Streptomyces fradiae",5,"VAL A 287;PHE A 170;GLY A 114;GLY A 113;TYR A 131","3R2 A 401 (-3.6A);None;None;None;None","1.23A","3owxA-4rihA:4.8;3owxB-4rihA:4.9","1rh0A-4rihA:19.34"],["4PGH_D_SAMD401_0","CAFFEIC ACID O-METHYLTRANSFERASE","4rih","GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE","Streptomyces fradiae;Streptomyces cyanogenus",5,"GLY A 285;GLY A 286;THR A 138;PHE A 229;ILE A 301","3R2 A 401 (-3.3A);3R2 A 401 (-3.4A);None;None;None","1.02A","4pghD-4rihA:2.9","3owxA-4rihA:21.23;3owxB-4rihA:21.23"],["4QCK_A_ASDA404_1","3-KETOSTEROID-9-ALPHA-MONOOXYGENASE OXYGENASE SUBUNIT","4rih","GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE","Streptomyces cyanogenus;Streptomyces fradiae",5,"HIS A 283;GLN A 299;ALA A 292;LEU A 270;GLY A 218","3R2 A 401 (-4.3A);None;None;3R2 A 401 (-3.7A);3R2 A 401 (-3.5A)","1.26A","4qckA-4rihA:undetectable","4pghD-4rihA:23.96"],["5JCN_B_ASCB502_0","OS09G0567300 PROTEIN","4rih","GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE","Streptomyces fradiae;Streptomyces cyanogenus",4,"GLU A  80;GLY A 305;PHE A 223;ARG A 220","None;None;None;3R2 A 401 (-3.7A)","1.41A","5jcnB-4rihA:2.7","4qckA-4rihA:23.49"],["5YW0_A_ACTA409_0","UNCHARACTERIZED PROTEIN KDOO","4rih","GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE","Streptomyces fradiae;Streptomyces cyanogenus",3,"ASP A 137;PHE A  88;ARG A 220","3R2 A 401 (-3.6A);None;3R2 A 401 (-3.7A)","0.94A","5yw0A-4rihA:undetectable","5jcnB-4rihA:24.69"],["6CDU_B_EY4B500_0","CHIMERIC ALPHA1GABAA RECEPTOR","4rih","GLYCOSYL TRANSFERASE HOMOLOG,GLYCOSYL TRANSFERASE","Streptomyces fradiae;Streptomyces cyanogenus",4,"VAL A 268;TRP A 267;ALA A 247;THR A 216","3R2 A 401 (-4.6A);3R2 A 401 (-3.5A);3R2 A 401 (-3.5A);3R2 A 401 ( 4.8A)","1.04A","6cduB-4rihA:undetectable;6cduC-4rihA:undetectable","5yw0A-4rihA:21.30"]]