SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3PQ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 5 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.29A 1os2A-4wk7A:
10.6		 1os2A-4wk7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.25A 1os2D-4wk7A:
10.6		 1os2D-4wk7A:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R55_A_097A518_1
(ADAM 33)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		6 / 10 THR A 329
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
 3PQ  A 505 ( 4.6A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.39A 1r55A-4wk7A:
25.9		 1r55A-4wk7A:
30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.19A 1uttA-4wk7A:
10.9		 1uttA-4wk7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.27A 1utzA-4wk7A:
10.7		 1utzA-4wk7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.24A 1utzB-4wk7A:
10.8		 1utzB-4wk7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 6 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.24A 1y93A-4wk7A:
10.9		 1y93A-4wk7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.20A 2hu6A-4wk7A:
10.8		 2hu6A-4wk7A:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_A_097A1001_1
(ADAMTS-1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		7 / 9 ASP A 328
LEU A 330
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
 None
3PQ  A 505 (-4.5A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.37A 2jihA-4wk7A:
36.1		 2jihA-4wk7A:
53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_B_097B1001_1
(ADAMTS-1)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		7 / 8 ASP A 328
LEU A 330
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
 None
3PQ  A 505 (-4.5A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.51A 2jihB-4wk7A:
35.9		 2jihB-4wk7A:
53.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 6 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.34A 2ow9A-4wk7A:
10.5		 2ow9A-4wk7A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.30A 2ow9B-4wk7A:
10.3		 2ow9B-4wk7A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.34A 2ozrC-4wk7A:
10.2		 2ozrC-4wk7A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.37A 2ozrD-4wk7A:
10.2		 2ozrD-4wk7A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.32A 2ozrE-4wk7A:
10.1		 2ozrE-4wk7A:
25.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		7 / 9 ASP A 328
LEU A 330
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
 None
3PQ  A 505 (-4.5A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.30A 3hy7A-4wk7A:
34.8		 3hy7A-4wk7A:
47.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		7 / 9 ASP A 328
LEU A 330
THR A 358
HIS A 361
GLU A 362
HIS A 365
HIS A 371
 None
3PQ  A 505 (-4.5A)
3PQ  A 505 ( 4.0A)
ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.30A 3hy7B-4wk7A:
33.8		 3hy7B-4wk7A:
47.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 5 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.28A 3kecA-4wk7A:
10.5		 3kecA-4wk7A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		3 / 3 HIS A 361
GLU A 362
HIS A 365
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
 0.20A 3kecB-4wk7A:
10.3		 3kecB-4wk7A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 5 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.24A 3likA-4wk7A:
10.9		 3likA-4wk7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.23A 3lilA-4wk7A:
10.9		 3lilA-4wk7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 5 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.22A 3ljgA-4wk7A:
11.0		 3ljgA-4wk7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 5 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.25A 3lkaA-4wk7A:
10.8		 3lkaA-4wk7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 6 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.41A 4a7bA-4wk7A:
10.2		 4a7bA-4wk7A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.23A 5n5jA-4wk7A:
10.9		 5n5jA-4wk7A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens) 		4 / 5 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.26A 5n5kA-4wk7A:
10.9		 5n5kA-4wk7A:
19.67