SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3PP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		4 / 8 ALA A 183
LYS A  14
SER A 206
ALA A 205
 3PP  A1226 (-4.4A)
3PP  A1226 (-3.3A)
3PP  A1226 (-2.8A)
3PP  A1226 (-3.1A)
 0.76A 2vh3B-1hg3A:
undetectable		 2vh3B-1hg3A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		5 / 12 LEU A 180
LEU A 203
GLY A 182
VAL A 122
THR A 166
 None
3PP  A1226 ( 4.4A)
None
None
None
 1.37A 4olmA-1hg3A:
undetectable		 4olmA-1hg3A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		3 / 3 LEU A  94
LEU A 180
ASN A  12
 None
None
3PP  A1226 (-3.9A)
 0.71A 4otwA-1hg3A:
undetectable		 4otwA-1hg3A:
24.34