SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3PH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		5 / 9 PHE C 329
LEU C 302
VAL C 301
THR C 308
VAL C 367
 3PH  C4006 ( 4.9A)
None
None
None
None
 1.44A 1dz8A-4pd4C:
undetectable		 1dz8A-4pd4C:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 125
LEU C 275
ILE C 122
PHE C 121
PHE C 333
 AOQ  C4003 ( 4.4A)
AOQ  C4003 (-3.8A)
None
3PH  C4006 ( 4.6A)
3PH  C4006 (-4.1A)
 1.01A 2ygqA-4pd4C:
undetectable		 2ygqA-4pd4C:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 3th1 CHLOROCATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		4 / 5 THR A 183
ILE A 166
GLU A  45
PHE A  53
 None
DTD  A 301 ( 4.5A)
None
3PH  A 302 ( 4.9A)
 1.12A 4ac9C-3th1A:
undetectable		 4ac9C-3th1A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3th1 CHLOROCATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		4 / 5 THR A 183
ILE A 166
GLU A  45
PHE A  53
 None
DTD  A 301 ( 4.5A)
None
3PH  A 302 ( 4.9A)
 1.14A 4acaC-3th1A:
undetectable		 4acaC-3th1A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3th1 CHLOROCATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		4 / 5 THR A 183
ILE A 166
GLU A  45
PHE A  53
 None
DTD  A 301 ( 4.5A)
None
3PH  A 302 ( 4.9A)
 1.21A 4acbC-3th1A:
undetectable		 4acbC-3th1A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		4 / 6 PHE C 329
LEU C 302
VAL C 301
VAL C 367
 3PH  C4006 ( 4.9A)
None
None
None
 1.12A 4ek1A-4pd4C:
undetectable		 4ek1A-4pd4C:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		4 / 7 PHE C 329
TYR C 359
PRO C 277
PHE C 278
 3PH  C4006 ( 4.9A)
None
None
AOQ  C4003 ( 4.6A)
 1.35A 4grqA-4pd4C:
undetectable
4grqC-4pd4C:
undetectable		 4grqA-4pd4C:
13.81
4grqC-4pd4C:
13.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		10 / 10 TRP C  29
PHE C  94
MET C  97
ALA C  98
TYR C 102
TYR C 103
THR C 317
PHE C 326
PHE C 327
VAL C 330
 3PH  C4006 (-3.6A)
3PH  C4006 ( 4.8A)
3PH  C4006 ( 4.1A)
3PH  C4006 (-3.6A)
3PH  C4006 (-3.3A)
3PH  C4006 (-4.9A)
3PH  C4006 (-3.3A)
None
3PH  C4006 ( 4.9A)
3PH  C4006 ( 4.4A)
 0.35A 6hu9C-4pd4C:
5.6		 6hu9C-4pd4C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		12 / 12 TRP C  29
PHE C  94
MET C  95
MET C  97
ALA C  98
TYR C 102
TYR C 103
THR C 317
PHE C 327
VAL C 330
VAL C 334
TYR C 359
 3PH  C4006 (-3.6A)
3PH  C4006 ( 4.8A)
None
3PH  C4006 ( 4.1A)
3PH  C4006 (-3.6A)
3PH  C4006 (-3.3A)
3PH  C4006 (-4.9A)
3PH  C4006 (-3.3A)
3PH  C4006 ( 4.9A)
3PH  C4006 ( 4.4A)
None
None
 0.38A 6hu9N-4pd4C:
undetectable		 6hu9N-4pd4C:
100.00