SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3OH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1m33 BIOH PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 183
GLY A  23
GLY A  21
LEU A  19
GLY A  80
 3OH  A 300 (-4.3A)
None
3OH  A 300 (-3.6A)
None
None
 1.08A 1y4lA-1m33A:
undetectable		 1y4lA-1m33A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1m33 BIOH PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 180
LEU A 183
HIS A 235
PRO A 211
VAL A 214
 None
3OH  A 300 (-4.3A)
3OH  A 300 (-4.3A)
None
None
 1.09A 2pnjA-1m33A:
2.9		 2pnjA-1m33A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1m33 BIOH PROTEIN
(Escherichia
coli) 		4 / 4 ALA A 167
PRO A 171
LEU A  83
HIS A  20
 None
None
3OH  A 300 (-4.2A)
None
 1.47A 5eskA-1m33A:
0.0		 5eskA-1m33A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1m33 BIOH PROTEIN
(Escherichia
coli) 		5 / 12 GLY A  21
GLY A 119
VAL A 210
ILE A 120
GLY A 179
 3OH  A 300 (-3.6A)
None
None
None
None
 0.95A 5koxA-1m33A:
undetectable		 5koxA-1m33A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 1m33 BIOH PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 183
LEU A 180
GLY A 179
GLY A 178
VAL A 175
 3OH  A 300 (-4.3A)
None
None
None
None
 0.76A 5uc1A-1m33A:
undetectable		 5uc1A-1m33A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 1m33 BIOH PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 183
LEU A 180
GLY A 179
GLY A 178
VAL A 175
 3OH  A 300 (-4.3A)
None
None
None
None
 0.77A 5uc1B-1m33A:
undetectable		 5uc1B-1m33A:
15.56