SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3O3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QZZ_A_SAMA635_0 (ACLACINOMYCIN-10-HYD ROXYLASE)	3o31	THERMONICOTIANAMINE SYNTHASE (Methanothermobac ter thermautotrophic us)	5 / 12	TYR A 107 GLY A 130 GLY A 131 GLY A 132 ASP A 180	3O3 A 1 (-3.8A) None None None None	1.20A	1qzzA-3o31A: 15.1	1qzzA-3o31A: 21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FPJ_A_SAMA301_0 (PUTATIVE UNCHARACTERIZED PROTEIN)	3o31	THERMONICOTIANAMINE SYNTHASE (Methanothermobac ter thermautotrophic us)	11 / 12	GLN A 81 PHE A 128 ILE A 129 GLY A 130 VAL A 152 ILE A 154 ILE A 158 ALA A 195 LEU A 197 ARG A 203 VAL A 204	3O3 A 1 ( 4.8A) BR A 298 ( 4.8A) None None None None None 3O3 A 1 (-3.5A) 3O3 A 1 (-4.2A) None None	0.36A	3fpjA-3o31A: 42.7	3fpjA-3o31A: 99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FPJ_A_SAMA301_0 (PUTATIVE UNCHARACTERIZED PROTEIN)	3o31	THERMONICOTIANAMINE SYNTHASE (Methanothermobac ter thermautotrophic us)	9 / 12	MET A 78 PHE A 128 ILE A 129 GLY A 130 VAL A 152 ILE A 154 ALA A 195 LEU A 197 VAL A 204	None BR A 298 ( 4.8A) None None None None 3O3 A 1 (-3.5A) 3O3 A 1 (-4.2A) None	1.03A	3fpjA-3o31A: 42.7	3fpjA-3o31A: 99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FPJ_A_SAMA301_1 (PUTATIVE UNCHARACTERIZED PROTEIN)	3o31	THERMONICOTIANAMINE SYNTHASE (Methanothermobac ter thermautotrophic us)	6 / 6	TYR A 107 GLY A 132 THR A 137 GLU A 153 GLU A 155 GLU A 181	3O3 A 1 (-3.8A) None BR A 298 (-4.0A) None None None	0.58A	3fpjA-3o31A: 42.7	3fpjA-3o31A: 99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FPJ_B_SAMB301_0 (PUTATIVE UNCHARACTERIZED PROTEIN)	3o31	THERMONICOTIANAMINE SYNTHASE (Methanothermobac ter thermautotrophic us)	8 / 12	MET A 78 ILE A 129 ILE A 154 GLU A 155 ILE A 158 LEU A 197 ARG A 203 VAL A 204	None None None None None 3O3 A 1 (-4.2A) None None	0.93A	3fpjB-3o31A: 42.2	3fpjB-3o31A: 99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FPJ_B_SAMB301_0 (PUTATIVE UNCHARACTERIZED PROTEIN)	3o31	THERMONICOTIANAMINE SYNTHASE (Methanothermobac ter thermautotrophic us)	11 / 12	TYR A 107 PHE A 128 ILE A 129 VAL A 152 ILE A 154 GLU A 155 ILE A 158 LEU A 197 ARG A 203 VAL A 204 ARG A 221	3O3 A 1 (-3.8A) BR A 298 ( 4.8A) None None None None None 3O3 A 1 (-4.2A) None None 3O3 A 1 (-4.0A)	0.44A	3fpjB-3o31A: 42.2	3fpjB-3o31A: 99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FPJ_B_SAMB301_1 (PUTATIVE UNCHARACTERIZED PROTEIN)	3o31	THERMONICOTIANAMINE SYNTHASE (Methanothermobac ter thermautotrophic us)	7 / 7	GLN A 81 GLY A 130 GLY A 132 THR A 137 GLU A 153 GLU A 181 ALA A 195	3O3 A 1 ( 4.8A) None None BR A 298 (-4.0A) None None 3O3 A 1 (-3.5A)	0.30A	3fpjB-3o31A: 42.2	3fpjB-3o31A: 99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GAL_B_1GNB999_1 (GALECTIN-7)	3o31	THERMONICOTIANAMINE SYNTHASE (Methanothermobac ter thermautotrophic us)	4 / 6	ASN A 256 ARG A 221 ASN A 113 GLU A 114	3O3 A 1 (-3.4A) 3O3 A 1 (-4.0A) None None	1.36A	3galB-3o31A: undetectable	3galB-3o31A: 19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V3O_A_T1CA404_1 (TETX2 PROTEIN)	3o31	THERMONICOTIANAMINE SYNTHASE (Methanothermobac ter thermautotrophic us)	5 / 12	THR A 182 PHE A 205 ASN A 207 ALA A 195 GLY A 130	None None None 3O3 A 1 (-3.5A) None	1.18A	3v3oA-3o31A: 4.4	3v3oA-3o31A: 20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IV8_A_SAMA301_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	3o31	THERMONICOTIANAMINE SYNTHASE (Methanothermobac ter thermautotrophic us)	6 / 12	GLY A 130 GLY A 132 ILE A 154 ASP A 180 ARG A 221 ALA A 198	None None None None 3O3 A 1 (-4.0A) None	1.27A	4iv8A-3o31A: 12.2	4iv8A-3o31A: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IV8_B_SAMB301_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	3o31	THERMONICOTIANAMINE SYNTHASE (Methanothermobac ter thermautotrophic us)	6 / 12	GLY A 130 GLY A 132 ILE A 154 ASP A 180 ARG A 221 ALA A 198	None None None None 3O3 A 1 (-4.0A) None	1.30A	4iv8B-3o31A: 12.2	4iv8B-3o31A: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLB_A_TRPA901_0 (PROTEIN ARGONAUTE-2)	3o31	THERMONICOTIANAMINE SYNTHASE (Methanothermobac ter thermautotrophic us)	3 / 3	VAL A 194 ALA A 196 PHE A 128	None 3O3 A 1 (-3.4A) BR A 298 ( 4.8A)	0.93A	4olbA-3o31A: undetectable	4olbA-3o31A: 17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5N_A_IPHA901_0 (PROTEIN ARGONAUTE-2)	3o31	THERMONICOTIANAMINE SYNTHASE (Methanothermobac ter thermautotrophic us)	3 / 3	VAL A 194 ALA A 196 PHE A 128	None 3O3 A 1 (-3.4A) BR A 298 ( 4.8A)	0.91A	4w5nA-3o31A: undetectable	4w5nA-3o31A: 17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1K_B_LOCB502_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	3o31	THERMONICOTIANAMINE SYNTHASE (Methanothermobac ter thermautotrophic us)	5 / 12	VAL A 248 LEU A 136 LEU A 111 ASN A 113 ALA A 196	None None None None 3O3 A 1 (-3.4A)	1.17A	4x1kA-3o31A: undetectable 4x1kB-3o31A: undetectable	4x1kA-3o31A: 21.63 4x1kB-3o31A: 20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CF9_B_NCAB302_0 (RIBOSOME-INACTIVATIN G PROTEIN MOMORDIN I)	3o31	THERMONICOTIANAMINE SYNTHASE (Methanothermobac ter thermautotrophic us)	5 / 9	TYR A 73 ILE A 229 ILE A 39 ALA A 43 GLU A 40	3O3 A 1 (-4.4A) None None None None	1.40A	5cf9B-3o31A: undetectable	5cf9B-3o31A: 24.42

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1QZZ_A_SAMA635_0","ACLACINOMYCIN-10-HYDROXYLASE","3o31","THERMONICOTIANAMINE SYNTHASE","Methanothermobacter thermautotrophicus",5,"TYR A 107;GLY A 130;GLY A 131;GLY A 132;ASP A 180","3O3 A   1 (-3.8A);None;None;None;None","1.20A","1qzzA-3o31A:15.1",null],["3FPJ_A_SAMA301_0","PUTATIVE UNCHARACTERIZED PROTEIN","3o31","THERMONICOTIANAMINE SYNTHASE","Methanothermobacter thermautotrophicus",11,"GLN A  81;PHE A 128;ILE A 129;GLY A 130;VAL A 152;ILE A 154;ILE A 158;ALA A 195;LEU A 197;ARG A 203;VAL A 204","3O3 A   1 ( 4.8A); BR A 298 ( 4.8A);None;None;None;None;None;3O3 A   1 (-3.5A);3O3 A   1 (-4.2A);None;None","0.36A","3fpjA-3o31A:42.7","1qzzA-3o31A:21.11"],["3FPJ_A_SAMA301_0","PUTATIVE UNCHARACTERIZED PROTEIN","3o31","THERMONICOTIANAMINE SYNTHASE","Methanothermobacter thermautotrophicus",9,"MET A  78;PHE A 128;ILE A 129;GLY A 130;VAL A 152;ILE A 154;ALA A 195;LEU A 197;VAL A 204","None; BR A 298 ( 4.8A);None;None;None;None;3O3 A   1 (-3.5A);3O3 A   1 (-4.2A);None","1.03A","3fpjA-3o31A:42.7","3fpjA-3o31A:99.66"],["3FPJ_A_SAMA301_1","PUTATIVE UNCHARACTERIZED PROTEIN","3o31","THERMONICOTIANAMINE SYNTHASE","Methanothermobacter thermautotrophicus",6,"TYR A 107;GLY A 132;THR A 137;GLU A 153;GLU A 155;GLU A 181","3O3 A   1 (-3.8A);None; BR A 298 (-4.0A);None;None;None","0.58A","3fpjA-3o31A:42.7","3fpjA-3o31A:99.66"],["3FPJ_B_SAMB301_0","PUTATIVE UNCHARACTERIZED PROTEIN","3o31","THERMONICOTIANAMINE SYNTHASE","Methanothermobacter thermautotrophicus",8,"MET A  78;ILE A 129;ILE A 154;GLU A 155;ILE A 158;LEU A 197;ARG A 203;VAL A 204","None;None;None;None;None;3O3 A   1 (-4.2A);None;None","0.93A","3fpjB-3o31A:42.2","3fpjA-3o31A:99.66"],["3FPJ_B_SAMB301_0","PUTATIVE UNCHARACTERIZED PROTEIN","3o31","THERMONICOTIANAMINE SYNTHASE","Methanothermobacter thermautotrophicus",11,"TYR A 107;PHE A 128;ILE A 129;VAL A 152;ILE A 154;GLU A 155;ILE A 158;LEU A 197;ARG A 203;VAL A 204;ARG A 221","3O3 A   1 (-3.8A); BR A 298 ( 4.8A);None;None;None;None;None;3O3 A   1 (-4.2A);None;None;3O3 A   1 (-4.0A)","0.44A","3fpjB-3o31A:42.2","3fpjB-3o31A:99.66"],["3FPJ_B_SAMB301_1","PUTATIVE UNCHARACTERIZED PROTEIN","3o31","THERMONICOTIANAMINE SYNTHASE","Methanothermobacter thermautotrophicus",7,"GLN A  81;GLY A 130;GLY A 132;THR A 137;GLU A 153;GLU A 181;ALA A 195","3O3 A   1 ( 4.8A);None;None; BR A 298 (-4.0A);None;None;3O3 A   1 (-3.5A)","0.30A","3fpjB-3o31A:42.2","3fpjB-3o31A:99.66"],["3GAL_B_1GNB999_1","GALECTIN-7","3o31","THERMONICOTIANAMINE SYNTHASE","Methanothermobacter thermautotrophicus",4,"ASN A 256;ARG A 221;ASN A 113;GLU A 114","3O3 A   1 (-3.4A);3O3 A   1 (-4.0A);None;None","1.36A","3galB-3o31A:undetectable","3fpjB-3o31A:99.66"],["3V3O_A_T1CA404_1","TETX2 PROTEIN","3o31","THERMONICOTIANAMINE SYNTHASE","Methanothermobacter thermautotrophicus",5,"THR A 182;PHE A 205;ASN A 207;ALA A 195;GLY A 130","None;None;None;3O3 A   1 (-3.5A);None","1.18A","3v3oA-3o31A:4.4","3galB-3o31A:19.52"],["4IV8_A_SAMA301_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE,PUTATIVE","3o31","THERMONICOTIANAMINE SYNTHASE","Methanothermobacter thermautotrophicus",6,"GLY A 130;GLY A 132;ILE A 154;ASP A 180;ARG A 221;ALA A 198","None;None;None;None;3O3 A   1 (-4.0A);None","1.27A","4iv8A-3o31A:12.2","3v3oA-3o31A:20.30"],["4IV8_B_SAMB301_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE,PUTATIVE","3o31","THERMONICOTIANAMINE SYNTHASE","Methanothermobacter thermautotrophicus",6,"GLY A 130;GLY A 132;ILE A 154;ASP A 180;ARG A 221;ALA A 198","None;None;None;None;3O3 A   1 (-4.0A);None","1.30A","4iv8B-3o31A:12.2","4iv8A-3o31A:20.54"],["4OLB_A_TRPA901_0","PROTEIN ARGONAUTE-2","3o31","THERMONICOTIANAMINE SYNTHASE","Methanothermobacter thermautotrophicus",3,"VAL A 194;ALA A 196;PHE A 128","None;3O3 A   1 (-3.4A); BR A 298 ( 4.8A)","0.93A","4olbA-3o31A:undetectable","4iv8B-3o31A:20.54"],["4W5N_A_IPHA901_0","PROTEIN ARGONAUTE-2","3o31","THERMONICOTIANAMINE SYNTHASE","Methanothermobacter thermautotrophicus",3,"VAL A 194;ALA A 196;PHE A 128","None;3O3 A   1 (-3.4A); BR A 298 ( 4.8A)","0.91A","4w5nA-3o31A:undetectable","4olbA-3o31A:17.27"],["4X1K_B_LOCB502_1","TUBULIN ALPHA CHAIN;TUBULIN BETA CHAIN","3o31","THERMONICOTIANAMINE SYNTHASE","Methanothermobacter thermautotrophicus",5,"VAL A 248;LEU A 136;LEU A 111;ASN A 113;ALA A 196","None;None;None;None;3O3 A   1 (-3.4A)","1.17A","4x1kA-3o31A:undetectable;4x1kB-3o31A:undetectable","4w5nA-3o31A:17.27"],["5CF9_B_NCAB302_0","RIBOSOME-INACTIVATING PROTEIN MOMORDIN I","3o31","THERMONICOTIANAMINE SYNTHASE","Methanothermobacter thermautotrophicus",5,"TYR A  73;ILE A 229;ILE A  39;ALA A  43;GLU A  40","3O3 A   1 (-4.4A);None;None;None;None","1.40A","5cf9B-3o31A:undetectable","4x1kA-3o31A:21.63;4x1kB-3o31A:20.31"]]