SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3NP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A 114
GLU A 245
THR A 244
 None
3NP  A 602 (-4.5A)
3NP  A 602 (-4.5A)
 0.84A 3v4tA-3p4sA:
undetectable		 3v4tA-3p4sA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 ARG A 115
PHE A 116
GLY A 118
ARG A 114
GLU A 122
 None
3NP  A 602 (-4.7A)
None
None
None
 1.29A 4bvaA-3p4sA:
3.0		 4bvaA-3p4sA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 ARG A 115
PHE A 116
GLY A 118
ARG A 114
GLU A 122
 None
3NP  A 602 (-4.7A)
None
None
None
 1.39A 4bvaB-3p4sA:
2.8		 4bvaB-3p4sA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A 390
HIS A 232
ARG A 287
 FAD  A 601 ( 3.2A)
3NP  A 602 (-4.7A)
3NP  A 602 (-1.4A)
 1.10A 5iaoC-3p4sA:
undetectable		 5iaoC-3p4sA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A 390
HIS A 232
ARG A 287
 FAD  A 601 ( 3.2A)
3NP  A 602 (-4.7A)
3NP  A 602 (-1.4A)
 1.16A 5iaoF-3p4sA:
undetectable		 5iaoF-3p4sA:
17.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 HIS A 232
HIS A 355
ARG A 390
 3NP  A 602 (-4.7A)
FAD  A 601 (-4.3A)
FAD  A 601 ( 3.2A)
 0.60A 6b58A-3p4sA:
63.5		 6b58A-3p4sA:
100.00