SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3KZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		6 / 12 LEU A 345
VAL A 353
ALA A 366
GLU A 387
GLY A 423
ALA A 480
 3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
None
None
3KZ  A 701 ( 4.8A)
 0.95A 1iepB-4ra4A:
20.8		 1iepB-4ra4A:
28.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		7 / 12 VAL A 353
ALA A 366
VAL A 420
ASP A 463
LYS A 465
ASN A 468
ASP A 481
 3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
3KZ  A 701 (-4.1A)
None
None
3KZ  A 701 (-4.1A)
3KZ  A 701 (-2.9A)
 0.79A 2fumA-4ra4A:
25.5		 2fumA-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		7 / 12 VAL A 353
ALA A 366
VAL A 420
ASP A 463
LYS A 465
ASN A 468
MET A 470
 3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
3KZ  A 701 (-4.1A)
None
None
3KZ  A 701 (-4.1A)
3KZ  A 701 ( 4.0A)
 0.83A 2fumA-4ra4A:
25.5		 2fumA-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		7 / 12 ALA A 366
MET A 417
TYR A 419
VAL A 420
LYS A 465
ASN A 468
ASP A 481
 3KZ  A 701 (-3.4A)
3KZ  A 701 (-4.2A)
None
3KZ  A 701 (-4.1A)
None
3KZ  A 701 (-4.1A)
3KZ  A 701 (-2.9A)
 0.81A 2fumB-4ra4A:
25.4		 2fumB-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		7 / 12 ALA A 366
MET A 417
TYR A 419
VAL A 420
LYS A 465
ASN A 468
MET A 470
 3KZ  A 701 (-3.4A)
3KZ  A 701 (-4.2A)
None
3KZ  A 701 (-4.1A)
None
3KZ  A 701 (-4.1A)
3KZ  A 701 ( 4.0A)
 0.76A 2fumB-4ra4A:
25.4		 2fumB-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		7 / 12 VAL A 353
ALA A 366
TYR A 419
VAL A 420
LYS A 465
ASN A 468
ASP A 481
 3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
None
3KZ  A 701 (-4.1A)
None
3KZ  A 701 (-4.1A)
3KZ  A 701 (-2.9A)
 0.78A 2fumB-4ra4A:
25.4		 2fumB-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		7 / 12 VAL A 353
ALA A 366
TYR A 419
VAL A 420
LYS A 465
ASN A 468
MET A 470
 3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
None
3KZ  A 701 (-4.1A)
None
3KZ  A 701 (-4.1A)
3KZ  A 701 ( 4.0A)
 0.73A 2fumB-4ra4A:
25.4		 2fumB-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		6 / 12 LEU A 345
GLY A 346
VAL A 353
ALA A 366
TYR A 419
VAL A 420
 3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.3A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
None
3KZ  A 701 (-4.1A)
 0.70A 2fumC-4ra4A:
23.9		 2fumC-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		6 / 12 LEU A 345
VAL A 353
ALA A 366
TYR A 419
VAL A 420
MET A 470
 3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
None
3KZ  A 701 (-4.1A)
3KZ  A 701 ( 4.0A)
 0.80A 2fumC-4ra4A:
23.9		 2fumC-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		6 / 12 VAL A 353
ALA A 366
TYR A 419
VAL A 420
ASN A 468
MET A 470
 3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
None
3KZ  A 701 (-4.1A)
3KZ  A 701 (-4.1A)
3KZ  A 701 ( 4.0A)
 0.83A 2fumC-4ra4A:
23.9		 2fumC-4ra4A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		5 / 12 VAL A 353
ALA A 366
LYS A 368
GLU A 387
LEU A 391
 3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
3KZ  A 701 ( 4.7A)
None
None
 0.76A 3hegA-4ra4A:
20.1		 3hegA-4ra4A:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		6 / 10 LEU A 345
GLY A 346
GLY A 348
VAL A 353
ALA A 366
TYR A 419
 3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.3A)
None
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
None
 0.43A 4ckjA-4ra4A:
24.9		 4ckjA-4ra4A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		8 / 12 PHE A 350
VAL A 353
ALA A 366
ASP A 424
ASP A 463
LYS A 465
ASN A 468
ASP A 481
 3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
None
None
None
3KZ  A 701 (-4.1A)
3KZ  A 701 (-2.9A)
 1.00A 4i41A-4ra4A:
28.1		 4i41A-4ra4A:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		7 / 12 LEU A 345
VAL A 353
LYS A 368
TYR A 419
GLY A 423
ALA A 480
ASP A 481
 3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.9A)
3KZ  A 701 ( 4.7A)
None
None
3KZ  A 701 ( 4.8A)
3KZ  A 701 (-2.9A)
 1.10A 4otwA-4ra4A:
20.1		 4otwA-4ra4A:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		6 / 12 ALA A 366
GLU A 387
THR A 401
MET A 417
TYR A 419
ALA A 480
 3KZ  A 701 (-3.4A)
None
3KZ  A 701 (-3.6A)
3KZ  A 701 (-4.2A)
None
3KZ  A 701 ( 4.8A)
 0.58A 4qmnA-4ra4A:
29.4		 4qmnA-4ra4A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		6 / 12 ALA A 366
GLU A 387
THR A 401
MET A 417
TYR A 419
ASP A 481
 3KZ  A 701 (-3.4A)
None
3KZ  A 701 (-3.6A)
3KZ  A 701 (-4.2A)
None
3KZ  A 701 (-2.9A)
 0.74A 4qmnA-4ra4A:
29.4		 4qmnA-4ra4A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		6 / 12 ALA A 366
LYS A 368
GLU A 387
THR A 401
MET A 417
TYR A 419
 3KZ  A 701 (-3.4A)
3KZ  A 701 ( 4.7A)
None
3KZ  A 701 (-3.6A)
3KZ  A 701 (-4.2A)
None
 0.78A 4qmnA-4ra4A:
29.4		 4qmnA-4ra4A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		6 / 12 GLY A 346
VAL A 353
ALA A 366
THR A 401
MET A 417
TYR A 419
 3KZ  A 701 (-3.3A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
3KZ  A 701 (-3.6A)
3KZ  A 701 (-4.2A)
None
 0.54A 4qmzA-4ra4A:
29.3		 4qmzA-4ra4A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		5 / 12 VAL A 353
ALA A 366
LYS A 368
LEU A 391
PHE A 482
 3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
3KZ  A 701 ( 4.7A)
None
None
 0.83A 5cswA-4ra4A:
21.2		 5cswA-4ra4A:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		5 / 12 VAL A 353
ALA A 366
LYS A 368
LEU A 391
PHE A 482
 3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
3KZ  A 701 ( 4.7A)
None
None
 0.86A 5cswB-4ra4A:
21.2		 5cswB-4ra4A:
27.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		6 / 7 GLY A 346
GLY A 348
SER A 349
GLY A 351
VAL A 353
LEU A 370
 3KZ  A 701 (-3.3A)
None
None
None
3KZ  A 701 (-3.9A)
None
 0.71A 5izjB-4ra4A:
37.3		 5izjB-4ra4A:
36.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		5 / 7 GLY A 346
GLY A 348
SER A 349
VAL A 353
LEU A 370
 3KZ  A 701 (-3.3A)
None
None
3KZ  A 701 (-3.9A)
None
 0.71A 5izjA-4ra4A:
37.5		 5izjA-4ra4A:
36.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		5 / 7 GLY A 346
SER A 349
VAL A 353
LYS A 368
LEU A 370
 3KZ  A 701 (-3.3A)
None
3KZ  A 701 (-3.9A)
3KZ  A 701 ( 4.7A)
None
 0.70A 5izjA-4ra4A:
37.5		 5izjA-4ra4A:
36.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		5 / 7 GLY A 346
GLY A 348
SER A 349
VAL A 353
LYS A 368
 3KZ  A 701 (-3.3A)
None
None
3KZ  A 701 (-3.9A)
3KZ  A 701 ( 4.7A)
 0.64A 5j5xA-4ra4A:
37.6		 5j5xA-4ra4A:
36.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		6 / 10 LEU A 345
VAL A 353
ALA A 366
MET A 417
TYR A 419
VAL A 420
 3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
3KZ  A 701 (-4.2A)
None
3KZ  A 701 (-4.1A)
 0.67A 5n3hA-4ra4A:
38.2		 5n3hA-4ra4A:
36.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		5 / 12 LEU A 345
GLY A 346
VAL A 353
ALA A 366
ALA A 480
 3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.3A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
3KZ  A 701 ( 4.8A)
 0.33A 5xv7A-4ra4A:
24.3		 5xv7A-4ra4A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4ra4 PROTEIN KINASE C
(Homo
sapiens) 		7 / 12 LEU A 345
VAL A 353
ALA A 366
LYS A 368
GLU A 387
GLY A 423
ALA A 480
 3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
3KZ  A 701 ( 4.7A)
None
None
3KZ  A 701 ( 4.8A)
 0.92A 5zv2B-4ra4A:
20.7		 5zv2B-4ra4A:
15.31