SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3H1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 3h1l CYTOCHROME B
(Gallus
gallus) 		4 / 8 HIS C  98
LEU C 198
THR C 194
HIS C 197
 HEM  C 502 (-3.2A)
3H1  C2002 ( 4.0A)
HEM  C 502 (-3.9A)
HEM  C 502 (-3.2A)
 1.06A 1azmA-3h1lC:
undetectable		 1azmA-3h1lC:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 12 LEU C  42
LEU C 198
GLY C  35
HIS C  98
PHE C  91
 None
3H1  C2002 ( 4.0A)
HEM  C 502 (-3.2A)
HEM  C 502 (-3.2A)
None
 1.41A 1d4fC-3h1lC:
undetectable		 1d4fC-3h1lC:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 3h1l CYTOCHROME B
(Gallus
gallus) 		6 / 12 ALA C 278
ILE C 281
MET C 125
LEU C 302
LEU C 329
LEU C 333
 3H1  C2001 ( 3.7A)
None
3H1  C2001 ( 4.7A)
HEM  C 502 ( 4.9A)
None
PEE  C2007 ( 4.0A)
 1.22A 1dtlA-3h1lC:
undetectable		 1dtlA-3h1lC:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		6 / 11 GLY C  87
ALA C  88
PHE C  91
ALA C 128
PHE C 275
LEU C 124
 None
HEM  C 501 ( 3.8A)
None
HEM  C 501 (-4.1A)
3H1  C2001 (-4.5A)
None
 1.48A 1ukbA-3h1lC:
undetectable		 1ukbA-3h1lC:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 12 ILE C  95
PHE C  96
ILE C 301
ILE C 305
LEU C 122
 None
PEE  C2007 (-3.9A)
None
None
3H1  C2001 ( 4.8A)
 1.18A 2rlcA-3h1lC:
undetectable		 2rlcA-3h1lC:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 12 LEU C  42
LEU C 198
GLY C  35
HIS C  98
PHE C  91
 None
3H1  C2002 ( 4.0A)
HEM  C 502 (-3.2A)
HEM  C 502 (-3.2A)
None
 1.34A 3glqA-3h1lC:
undetectable		 3glqA-3h1lC:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 12 LEU C  42
LEU C 198
GLY C  35
HIS C  98
PHE C  91
 None
3H1  C2002 ( 4.0A)
HEM  C 502 (-3.2A)
HEM  C 502 (-3.2A)
None
 1.31A 3glqB-3h1lC:
undetectable		 3glqB-3h1lC:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 3h1l CYTOCHROME B
(Gallus
gallus) 		7 / 12 GLY C 143
VAL C 146
ILE C 147
ILE C 269
PRO C 271
TYR C 279
LEU C 282
 3H1  C2001 (-3.3A)
3H1  C2001 (-4.4A)
3H1  C2001 (-4.7A)
None
3H1  C2001 (-3.8A)
3H1  C2001 (-4.2A)
3H1  C2001 (-4.9A)
 0.61A 4pd4C-3h1lC:
52.8		 4pd4C-3h1lC:
52.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 3h1l CYTOCHROME B
(Gallus
gallus) 		7 / 12 PHE C 129
GLY C 143
VAL C 146
ILE C 147
ILE C 269
PRO C 271
LEU C 282
 3H1  C2001 ( 4.7A)
3H1  C2001 (-3.3A)
3H1  C2001 (-4.4A)
3H1  C2001 (-4.7A)
None
3H1  C2001 (-3.8A)
3H1  C2001 (-4.9A)
 0.86A 4pd4C-3h1lC:
52.8		 4pd4C-3h1lC:
52.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 12 VAL C 299
LEU C 302
ILE C  99
ILE C  95
MET C 125
 None
HEM  C 502 ( 4.9A)
HEM  C 502 (-3.9A)
None
3H1  C2001 ( 4.7A)
 0.82A 4y0rA-3h1lC:
undetectable		 4y0rA-3h1lC:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3h1l CYTOCHROME B
(Gallus
gallus) 		4 / 7 HIS C 268
ILE C 269
TYR C 279
ARG C 283
 None
None
3H1  C2001 (-4.2A)
None
 0.89A 5kkzC-3h1lC:
undetectable
5kkzE-3h1lC:
48.7		 5kkzC-3h1lC:
16.71
5kkzE-3h1lC:
44.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3h1l CYTOCHROME B
(Gallus
gallus) 		4 / 7 HIS C 268
ILE C 269
TYR C 279
ARG C 283
 None
None
3H1  C2001 (-4.2A)
None
 0.91A 5kkzK-3h1lC:
48.3
5kkzQ-3h1lC:
undetectable		 5kkzK-3h1lC:
44.82
5kkzQ-3h1lC:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3h1l CYTOCHROME B
(Gallus
gallus) 		4 / 7 HIS C 268
ILE C 269
TYR C 279
ARG C 283
 None
None
3H1  C2001 (-4.2A)
None
 0.93A 5kkzM-3h1lC:
undetectable
5kkzO-3h1lC:
48.7		 5kkzM-3h1lC:
16.71
5kkzO-3h1lC:
44.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 12 LEU C  42
LEU C 198
GLY C  35
HIS C  98
PHE C  91
 None
3H1  C2002 ( 4.0A)
HEM  C 502 (-3.2A)
HEM  C 502 (-3.2A)
None
 1.27A 6aphA-3h1lC:
undetectable		 6aphA-3h1lC:
21.15