SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3GP'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FDU_C_ESTC353_1 (17-BETA-HYDROXYSTERO ID DEHYDROGENASE)	4w8x	CRISPR SYSTEM CMR SUBUNIT CMR1-1 (Pyrococcus furiosus)	5 / 12	SER A 153 VAL A 149 GLY A 150 LEU A 16 SER A 119	3GP A 402 ( 2.2A) None None None None	1.22A	1fduC-4w8xA: undetectable	1fduC-4w8xA: 21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JB7_B_ACTB1169_0 (HYPOTHETICAL PROTEIN PAE2307)	4w8x	CRISPR SYSTEM CMR SUBUNIT CMR1-1 (Pyrococcus furiosus)	3 / 3	ARG A 28 ARG A 154 ARG A 152	3GP A 402 ( 4.9A) PO4 A 401 ( 3.2A) PO4 A 401 (-3.5A)	1.19A	2jb7A-4w8xA: undetectable 2jb7B-4w8xA: 1.7 2jb7C-4w8xA: 1.7	2jb7A-4w8xA: 19.58 2jb7B-4w8xA: 19.58 2jb7C-4w8xA: 19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JB7_B_ACTB1169_0 (HYPOTHETICAL PROTEIN PAE2307)	4w8x	CRISPR SYSTEM CMR SUBUNIT CMR1-1 (Pyrococcus furiosus)	3 / 3	ARG A 154 ARG A 152 ARG A 28	PO4 A 401 ( 3.2A) PO4 A 401 (-3.5A) 3GP A 402 ( 4.9A)	1.20A	2jb7A-4w8xA: undetectable 2jb7B-4w8xA: 1.7 2jb7C-4w8xA: 1.7	2jb7A-4w8xA: 19.58 2jb7B-4w8xA: 19.58 2jb7C-4w8xA: 19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FO7_A_IMNA301_1 (PHOSPHOLIPASE A2 VRV-PL-VIIIA)	1rms	RIBONUCLEASE MS (Aspergillus phoenicis)	4 / 5	HIS A 39 ASP A 36 TYR A 37 PRO A 59	3GP A 106 (-4.0A) None 3GP A 106 (-4.3A) None	1.50A	3fo7A-1rmsA: undetectable	3fo7A-1rmsA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H1X_A_IMNA301_1 (PHOSPHOLIPASE A2 VRV-PL-VIIIA)	1rms	RIBONUCLEASE MS (Aspergillus phoenicis)	4 / 5	HIS A 39 ASP A 36 TYR A 37 PRO A 59	3GP A 106 (-4.0A) None 3GP A 106 (-4.3A) None	1.49A	3h1xA-1rmsA: undetectable	3h1xA-1rmsA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KR4_C_AICC401_1 (OUTER MEMBRANE PROTEIN F)	4w8x	CRISPR SYSTEM CMR SUBUNIT CMR1-1 (Pyrococcus furiosus)	4 / 8	ARG A 306 ARG A 28 GLU A 304 ARG A 154	None 3GP A 402 ( 4.9A) None PO4 A 401 ( 3.2A)	1.42A	4kr4C-4w8xA: undetectable	4kr4C-4w8xA: 21.58

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FDU_C_ESTC353_1","17-BETA-HYDROXYSTEROID DEHYDROGENASE","4w8x","CRISPR SYSTEM CMR SUBUNIT CMR1-1","Pyrococcus furiosus",5,"SER A 153;VAL A 149;GLY A 150;LEU A  16;SER A 119","3GP A 402 ( 2.2A);None;None;None;None","1.22A","1fduC-4w8xA:undetectable",null],["2JB7_B_ACTB1169_0","HYPOTHETICAL PROTEIN PAE2307","4w8x","CRISPR SYSTEM CMR SUBUNIT CMR1-1","Pyrococcus furiosus",3,"ARG A  28;ARG A 154;ARG A 152","3GP A 402 ( 4.9A);PO4 A 401 ( 3.2A);PO4 A 401 (-3.5A)","1.19A","2jb7A-4w8xA:undetectable;2jb7B-4w8xA:1.7;2jb7C-4w8xA:1.7","1fduC-4w8xA:21.26"],["2JB7_B_ACTB1169_0","HYPOTHETICAL PROTEIN PAE2307","4w8x","CRISPR SYSTEM CMR SUBUNIT CMR1-1","Pyrococcus furiosus",3,"ARG A 154;ARG A 152;ARG A  28","PO4 A 401 ( 3.2A);PO4 A 401 (-3.5A);3GP A 402 ( 4.9A)","1.20A","2jb7A-4w8xA:undetectable;2jb7B-4w8xA:1.7;2jb7C-4w8xA:1.7","2jb7A-4w8xA:19.58;2jb7B-4w8xA:19.58;2jb7C-4w8xA:19.58"],["3FO7_A_IMNA301_1","PHOSPHOLIPASE A2 VRV-PL-VIIIA","1rms","RIBONUCLEASE MS","Aspergillus phoenicis",4,"HIS A  39;ASP A  36;TYR A  37;PRO A  59","3GP A 106 (-4.0A);None;3GP A 106 (-4.3A);None","1.50A","3fo7A-1rmsA:undetectable","2jb7A-4w8xA:19.58;2jb7B-4w8xA:19.58;2jb7C-4w8xA:19.58"],["3H1X_A_IMNA301_1","PHOSPHOLIPASE A2 VRV-PL-VIIIA","1rms","RIBONUCLEASE MS","Aspergillus phoenicis",4,"HIS A  39;ASP A  36;TYR A  37;PRO A  59","3GP A 106 (-4.0A);None;3GP A 106 (-4.3A);None","1.49A","3h1xA-1rmsA:undetectable","3fo7A-1rmsA:19.35"],["4KR4_C_AICC401_1","OUTER MEMBRANE PROTEIN F","4w8x","CRISPR SYSTEM CMR SUBUNIT CMR1-1","Pyrococcus furiosus",4,"ARG A 306;ARG A  28;GLU A 304;ARG A 154","None;3GP A 402 ( 4.9A);None;PO4 A 401 ( 3.2A)","1.42A","4kr4C-4w8xA:undetectable","3h1xA-1rmsA:19.35"]]