SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3GC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 152
SER A 462
LEU A 195
ILE A 445
SER A 158
 3GC  A 501 (-4.2A)
None
None
None
None
 1.05A 1eqgB-1m0wA:
undetectable		 1eqgB-1m0wA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 TRP A 361
GLN A 422
ASP A  39
ASP A 416
ILE A 419
 None
None
None
3GC  A 501 (-2.8A)
CL  A 512 ( 4.1A)
 1.20A 3b7pA-4x8dA:
undetectable		 3b7pA-4x8dA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 TRP A 361
GLN A 422
ASP A  39
ASP A 416
ILE A 419
 None
None
None
3GC  A 501 (-2.8A)
CL  A 512 ( 4.1A)
 1.24A 3b7pB-4x8dA:
undetectable		 3b7pB-4x8dA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 TRP A 361
GLN A 422
ASP A  39
ASP A 416
ILE A 419
 None
None
None
3GC  A 501 (-2.8A)
CL  A 512 ( 4.1A)
 1.17A 3b7pC-4x8dA:
undetectable		 3b7pC-4x8dA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 155
ARG A 128
ILE A 445
GLY A 463
SER A 189
 None
3GC  A 501 (-2.8A)
None
None
None
 1.44A 3bpxA-1m0wA:
0.0
3bpxB-1m0wA:
0.1		 3bpxA-1m0wA:
15.26
3bpxB-1m0wA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 230
ASP A 233
SER A 441
ASP A 486
TYR A 446
 3GC  A 501 (-3.8A)
None
None
None
None
 1.43A 3havC-1m0wA:
0.4		 3havC-1m0wA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 THR A 141
GLN A 137
GLN A 422
ILE A 423
 3GC  A 501 ( 4.6A)
AVI  A 502 (-3.1A)
None
None
 0.90A 3peoG-4x8dA:
undetectable		 3peoG-4x8dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 285
LEU A 237
GLU A 238
 3GC  A 501 (-3.8A)
None
None
 0.71A 4l3gF-1m0wA:
0.0		 4l3gF-1m0wA:
20.35