SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3G6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N2X_B_SAMB402_1 (S-ADENOSYL-METHYLTRA NSFERASE MRAW)	4ubt	ACETYL-COA ACETYLTRANSFERASE FADA5 (Mycobacterium tuberculosis)	4 / 5	VAL A 60 SER A 93 ASP A 250 GLN A 66	None 3G6 A 402 (-2.7A) None None	1.37A	1n2xB-4ubtA: undetectable	1n2xB-4ubtA: 22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3C6G_A_VD3A701_1 (CYTOCHROME P450 2R1)	4ubt	ACETYL-COA ACETYLTRANSFERASE FADA5 (Mycobacterium tuberculosis)	5 / 12	LEU A 128 PHE A 318 ALA A 378 ALA A 154 THR A 352	3G6 A 402 ( 4.3A) None 3G6 A 402 (-4.1A) None None	1.05A	3c6gA-4ubtA: undetectable	3c6gA-4ubtA: 22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3C6G_B_VD3B700_1 (CYTOCHROME P450 2R1)	4ubt	ACETYL-COA ACETYLTRANSFERASE FADA5 (Mycobacterium tuberculosis)	5 / 12	LEU A 128 PHE A 318 ALA A 378 ALA A 154 THR A 352	3G6 A 402 ( 4.3A) None 3G6 A 402 (-4.1A) None None	1.04A	3c6gB-4ubtA: undetectable	3c6gB-4ubtA: 22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CZH_B_D2VB602_1 (CYTOCHROME P450 2R1)	4ubt	ACETYL-COA ACETYLTRANSFERASE FADA5 (Mycobacterium tuberculosis)	5 / 12	LEU A 128 PHE A 318 ALA A 378 ALA A 154 THR A 352	3G6 A 402 ( 4.3A) None 3G6 A 402 (-4.1A) None None	1.02A	3czhB-4ubtA: undetectable	3czhB-4ubtA: 22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M0I_B_ACTB303_0 (SWI5-DEPENDENT HO EXPRESSION PROTEIN 2)	4ubt	ACETYL-COA ACETYLTRANSFERASE FADA5 (Mycobacterium tuberculosis)	4 / 5	VAL A 349 THR A 61 ASN A 131 LEU A 128	3G6 A 402 ( 4.7A) None None 3G6 A 402 ( 4.3A)	1.11A	5m0iB-4ubtA: undetectable	5m0iB-4ubtA: 20.45

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1N2X_B_SAMB402_1","S-ADENOSYL-METHYLTRANSFERASE MRAW","4ubt","ACETYL-COA ACETYLTRANSFERASE FADA5","Mycobacterium tuberculosis",4,"VAL A  60;SER A  93;ASP A 250;GLN A  66","None;3G6 A 402 (-2.7A);None;None","1.37A","1n2xB-4ubtA:undetectable",null],["3C6G_A_VD3A701_1","CYTOCHROME P450 2R1","4ubt","ACETYL-COA ACETYLTRANSFERASE FADA5","Mycobacterium tuberculosis",5,"LEU A 128;PHE A 318;ALA A 378;ALA A 154;THR A 352","3G6 A 402 ( 4.3A);None;3G6 A 402 (-4.1A);None;None","1.05A","3c6gA-4ubtA:undetectable","1n2xB-4ubtA:22.17"],["3C6G_B_VD3B700_1","CYTOCHROME P450 2R1","4ubt","ACETYL-COA ACETYLTRANSFERASE FADA5","Mycobacterium tuberculosis",5,"LEU A 128;PHE A 318;ALA A 378;ALA A 154;THR A 352","3G6 A 402 ( 4.3A);None;3G6 A 402 (-4.1A);None;None","1.04A","3c6gB-4ubtA:undetectable","3c6gA-4ubtA:22.29"],["3CZH_B_D2VB602_1","CYTOCHROME P450 2R1","4ubt","ACETYL-COA ACETYLTRANSFERASE FADA5","Mycobacterium tuberculosis",5,"LEU A 128;PHE A 318;ALA A 378;ALA A 154;THR A 352","3G6 A 402 ( 4.3A);None;3G6 A 402 (-4.1A);None;None","1.02A","3czhB-4ubtA:undetectable","3c6gB-4ubtA:22.29"],["5M0I_B_ACTB303_0","SWI5-DEPENDENT HO EXPRESSION PROTEIN 2","4ubt","ACETYL-COA ACETYLTRANSFERASE FADA5","Mycobacterium tuberculosis",4,"VAL A 349;THR A  61;ASN A 131;LEU A 128","3G6 A 402 ( 4.7A);None;None;3G6 A 402 ( 4.3A)","1.11A","5m0iB-4ubtA:undetectable","3czhB-4ubtA:22.29"]]