SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3CX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4z7x MDBA
(Actinomyces
oris) 		4 / 6 LEU A 196
TYR A 137
MET A 184
LEU A 188
 None
None
None
3CX  A 501 ( 4.9A)
 1.05A 1v54A-4z7xA:
undetectable
1v54J-4z7xA:
undetectable		 1v54A-4z7xA:
18.47
1v54J-4z7xA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4z7x MDBA
(Actinomyces
oris) 		4 / 6 LEU A 196
TYR A 137
MET A 184
LEU A 188
 None
None
None
3CX  A 501 ( 4.9A)
 1.03A 2dyrA-4z7xA:
undetectable
2dyrJ-4z7xA:
undetectable		 2dyrA-4z7xA:
18.47
2dyrJ-4z7xA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4z7x MDBA
(Actinomyces
oris) 		4 / 6 LEU A 196
TYR A 137
MET A 184
LEU A 188
 None
None
None
3CX  A 501 ( 4.9A)
 1.08A 2dysA-4z7xA:
1.1
2dysJ-4z7xA:
undetectable		 2dysA-4z7xA:
18.47
2dysJ-4z7xA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4z7x MDBA
(Actinomyces
oris) 		4 / 6 LEU A 196
TYR A 137
MET A 184
LEU A 188
 None
None
None
3CX  A 501 ( 4.9A)
 1.07A 2zxwA-4z7xA:
undetectable
2zxwJ-4z7xA:
undetectable		 2zxwA-4z7xA:
18.47
2zxwJ-4z7xA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4z7x MDBA
(Actinomyces
oris) 		4 / 4 GLY A 118
GLY A 116
THR A 114
LEU A  93
 3CX  A 501 (-3.2A)
3CX  A 501 (-3.1A)
None
None
 0.72A 3si7C-4z7xA:
undetectable
3si7D-4z7xA:
undetectable		 3si7C-4z7xA:
18.37
3si7D-4z7xA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 4z7x MDBA
(Actinomyces
oris) 		4 / 8 PHE A 135
PHE A 198
TRP A 113
TYR A 115
 None
None
None
3CX  A 501 (-4.6A)
 1.23A 4v2zC-4z7xA:
undetectable		 4v2zC-4z7xA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4z7x MDBA
(Actinomyces
oris) 		4 / 8 ASN A 200
PHE A 198
SER A 195
TYR A 115
 None
None
3CX  A 501 (-3.4A)
3CX  A 501 (-4.6A)
 1.09A 5amiB-4z7xA:
undetectable		 5amiB-4z7xA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4z7x MDBA
(Actinomyces
oris) 		4 / 8 PHE A 135
PHE A 198
TRP A 113
TYR A 115
 None
None
None
3CX  A 501 (-4.6A)
 1.18A 5amkA-4z7xA:
undetectable		 5amkA-4z7xA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3q75 FARNESYLTRANSFERASE
BETA SUBUNIT
(Cryptococcus
neoformans) 		4 / 8 ILE B 486
GLY B 489
PHE B  41
PHE B 383
 None
3CX  B 523 (-3.3A)
None
None
 0.87A 5hieD-3q75B:
undetectable		 5hieD-3q75B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4z7x MDBA
(Actinomyces
oris) 		4 / 6 LEU A 196
TYR A 137
MET A 184
LEU A 188
 None
None
None
3CX  A 501 ( 4.9A)
 1.09A 5x1fA-4z7xA:
undetectable
5x1fJ-4z7xA:
undetectable		 5x1fA-4z7xA:
18.47
5x1fJ-4z7xA:
12.61