SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3AM'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)
3ago RIBONUCLEASE U2
(Ustilago
sphaerogena)
3 / 3 GLU A  62
HIS A  41
ASP A 108
3AM  A 115 (-2.9A)
3AM  A 115 (-3.8A)
3AM  A 115 (-2.9A)
0.68A 1i9gA-3agoA:
undetectable
1i9gA-3agoA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 6 ILE A  18
VAL A  26
ILE A  74
ILE A 137
3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
None
None
0.81A 1uwhB-3c0iA:
24.6
1uwhB-3c0iA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 12 ILE A  18
VAL A  26
LYS A  41
VAL A  75
PHE A  91
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
3AM  A 338 (-2.9A)
None
3AM  A 338 (-3.6A)
3AM  A 338 (-4.7A)
0.56A 2eufB-3c0iA:
21.7
2eufB-3c0iA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 12 ILE A  18
VAL A  26
ALA A  39
PHE A  91
MET A  94
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
3AM  A 338 (-3.6A)
None
3AM  A 338 (-4.7A)
0.66A 2y7jA-3c0iA:
33.0
2y7jA-3c0iA:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 10 ILE A  18
VAL A  26
ALA A  39
PHE A  91
MET A  94
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
3AM  A 338 (-3.6A)
None
3AM  A 338 (-4.7A)
0.77A 2y7jB-3c0iA:
32.8
2y7jB-3c0iA:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 10 ILE A  18
VAL A  26
ALA A  39
PHE A  91
MET A  94
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
3AM  A 338 (-3.6A)
None
3AM  A 338 (-4.7A)
0.73A 2y7jC-3c0iA:
33.0
2y7jC-3c0iA:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 10 ILE A  18
VAL A  26
ALA A  39
PHE A  91
MET A  94
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
3AM  A 338 (-3.6A)
None
3AM  A 338 (-4.7A)
0.83A 2y7jD-3c0iA:
32.5
2y7jD-3c0iA:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 11 ILE A  18
ALA A  39
LYS A  41
PHE A  91
PHE A  93
MET A  94
3AM  A 338 (-4.5A)
3AM  A 338 (-3.3A)
3AM  A 338 (-2.9A)
3AM  A 338 (-3.6A)
3AM  A 338 ( 4.6A)
None
0.81A 3miyA-3c0iA:
24.3
3miyA-3c0iA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
5 / 9 ILE A  18
ALA A  39
PHE A  91
PHE A  93
MET A  94
3AM  A 338 (-4.5A)
3AM  A 338 (-3.3A)
3AM  A 338 (-3.6A)
3AM  A 338 ( 4.6A)
None
0.58A 3miyB-3c0iA:
24.0
3miyB-3c0iA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 9 ILE A  18
ALA A  39
PHE A  93
MET A  94
GLY A  96
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 (-3.3A)
3AM  A 338 ( 4.6A)
None
None
3AM  A 338 (-4.7A)
1.26A 3miyB-3c0iA:
24.0
3miyB-3c0iA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 9 ILE A  18
ALA A  39
VAL A  75
PHE A  91
PHE A  93
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 (-3.3A)
None
3AM  A 338 (-3.6A)
3AM  A 338 ( 4.6A)
3AM  A 338 (-4.7A)
0.60A 3ti1A-3c0iA:
23.9
3ti1A-3c0iA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 10 ILE A  18
ALA A  39
VAL A  75
PHE A  93
GLY A  96
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 (-3.3A)
None
3AM  A 338 ( 4.6A)
None
3AM  A 338 (-4.7A)
1.14A 4ks8A-3c0iA:
29.9
4ks8A-3c0iA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 7 ALA A  39
MET A  94
ASP A  98
LEU A 148
3AM  A 338 (-3.3A)
None
None
3AM  A 338 (-4.7A)
0.58A 4l9iA-3c0iA:
11.9
4l9iA-3c0iA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 7 VAL A  26
ALA A  39
MET A  94
LEU A 148
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
None
3AM  A 338 (-4.7A)
0.76A 4l9iA-3c0iA:
11.9
4l9iA-3c0iA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
7 / 12 VAL A  26
ALA A  39
LYS A  41
PHE A  93
MET A  94
GLY A  96
LEU A 148
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
3AM  A 338 (-2.9A)
3AM  A 338 ( 4.6A)
None
None
3AM  A 338 (-4.7A)
0.89A 4wa9B-3c0iA:
25.5
4wa9B-3c0iA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
3ago RIBONUCLEASE U2
(Ustilago
sphaerogena)
3 / 3 GLU A  62
HIS A  41
ASP A 108
3AM  A 115 (-2.9A)
3AM  A 115 (-3.8A)
3AM  A 115 (-2.9A)
0.49A 5c0oG-3agoA:
undetectable
5c0oG-3agoA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 7 GLY A  19
GLY A  21
VAL A  26
LYS A  41
None
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-2.9A)
0.22A 5izjA-3c0iA:
21.8
5izjA-3c0iA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 7 GLY A  19
GLY A  21
VAL A  26
LYS A  41
None
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-2.9A)
0.25A 5j5xA-3c0iA:
20.3
5j5xA-3c0iA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
7 / 12 ILE A  18
GLY A  19
VAL A  26
ALA A  39
VAL A  75
PHE A  91
LEU A 148
3AM  A 338 (-4.5A)
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
None
3AM  A 338 (-3.6A)
3AM  A 338 (-4.7A)
0.68A 5l2iA-3c0iA:
7.7
5l2iA-3c0iA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
7 / 12 ILE A  18
GLY A  19
VAL A  26
ALA A  39
VAL A  75
PHE A  91
LEU A 148
3AM  A 338 (-4.5A)
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
None
3AM  A 338 (-3.6A)
3AM  A 338 (-4.7A)
1.12A 5l2tA-3c0iA:
7.8
5l2tA-3c0iA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
5 / 9 ILE A  18
GLY A  19
VAL A  26
ALA A  39
MET A  94
3AM  A 338 (-4.5A)
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
None
0.59A 5lw1B-3c0iA:
23.2
5lw1B-3c0iA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 12 GLU A  16
ALA A  39
VAL A  75
PHE A  93
GLY A  96
LEU A 148
None
3AM  A 338 (-3.3A)
None
3AM  A 338 ( 4.6A)
None
3AM  A 338 (-4.7A)
0.84A 5te0A-3c0iA:
27.7
5te0A-3c0iA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 5 VAL A 165
PHE A  93
MET A  94
GLY A  96
None
3AM  A 338 ( 4.6A)
None
None
0.61A 6hd4A-3c0iA:
23.0
6hd4A-3c0iA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 6 VAL A 165
PHE A  93
MET A  94
GLY A  96
None
3AM  A 338 ( 4.6A)
None
None
0.64A 6hd4B-3c0iA:
23.2
6hd4B-3c0iA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
3ago RIBONUCLEASE U2
(Ustilago
sphaerogena)
4 / 8 ASP A  84
HIS A  41
GLU A  62
GLU A  49
None
3AM  A 115 (-3.8A)
3AM  A 115 (-2.9A)
3AM  A 115 (-2.8A)
1.03A 6mn4A-3agoA:
undetectable
6mn4A-3agoA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
3ago RIBONUCLEASE U2
(Ustilago
sphaerogena)
4 / 8 ASP A  84
HIS A  41
GLU A  62
GLU A  49
None
3AM  A 115 (-3.8A)
3AM  A 115 (-2.9A)
3AM  A 115 (-2.8A)
1.11A 6mn4B-3agoA:
undetectable
6mn4B-3agoA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
3ago RIBONUCLEASE U2
(Ustilago
sphaerogena)
4 / 8 ASP A  84
HIS A  41
GLU A  62
GLU A  49
None
3AM  A 115 (-3.8A)
3AM  A 115 (-2.9A)
3AM  A 115 (-2.8A)
1.06A 6mn4D-3agoA:
undetectable
6mn4D-3agoA:
16.86