SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3AM'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1I9G_A_SAMA301_1 (HYPOTHETICAL PROTEINRV2118C) |
3ago | RIBONUCLEASE U2 (Ustilagosphaerogena) | 3 / 3 | GLU A 62HIS A 41ASP A 108 | 3AM A 115 (-2.9A)3AM A 115 (-3.8A)3AM A 115 (-2.9A) | 0.68A | 1i9gA-3agoA:undetectable | 1i9gA-3agoA:16.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UWH_B_BAXB1723_2 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 4 / 6 | ILE A 18VAL A 26ILE A 74ILE A 137 | 3AM A 338 (-4.5A)3AM A 338 ( 4.1A)NoneNone | 0.81A | 1uwhB-3c0iA:24.6 | 1uwhB-3c0iA:25.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2EUF_B_LQQB401_1 (CELL DIVISIONPROTEIN KINASE 6) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 6 / 12 | ILE A 18VAL A 26LYS A 41VAL A 75PHE A 91LEU A 148 | 3AM A 338 (-4.5A)3AM A 338 ( 4.1A)3AM A 338 (-2.9A)None3AM A 338 (-3.6A)3AM A 338 (-4.7A) | 0.56A | 2eufB-3c0iA:21.7 | 2eufB-3c0iA:28.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Y7J_A_B49A1294_1 (PHOSPHORYLASE BKINASE GAMMACATALYTIC CHAIN,TESTIS/LIVER ISOFORM) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 6 / 12 | ILE A 18VAL A 26ALA A 39PHE A 91MET A 94LEU A 148 | 3AM A 338 (-4.5A)3AM A 338 ( 4.1A)3AM A 338 (-3.3A)3AM A 338 (-3.6A)None3AM A 338 (-4.7A) | 0.66A | 2y7jA-3c0iA:33.0 | 2y7jA-3c0iA:28.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Y7J_B_B49B1294_1 (PHOSPHORYLASE BKINASE GAMMACATALYTIC CHAIN,TESTIS/LIVER ISOFORM) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 6 / 10 | ILE A 18VAL A 26ALA A 39PHE A 91MET A 94LEU A 148 | 3AM A 338 (-4.5A)3AM A 338 ( 4.1A)3AM A 338 (-3.3A)3AM A 338 (-3.6A)None3AM A 338 (-4.7A) | 0.77A | 2y7jB-3c0iA:32.8 | 2y7jB-3c0iA:28.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Y7J_C_B49C1294_1 (PHOSPHORYLASE BKINASE GAMMACATALYTIC CHAIN,TESTIS/LIVER ISOFORM) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 6 / 10 | ILE A 18VAL A 26ALA A 39PHE A 91MET A 94LEU A 148 | 3AM A 338 (-4.5A)3AM A 338 ( 4.1A)3AM A 338 (-3.3A)3AM A 338 (-3.6A)None3AM A 338 (-4.7A) | 0.73A | 2y7jC-3c0iA:33.0 | 2y7jC-3c0iA:28.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Y7J_D_B49D1294_1 (PHOSPHORYLASE BKINASE GAMMACATALYTIC CHAIN,TESTIS/LIVER ISOFORM) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 6 / 10 | ILE A 18VAL A 26ALA A 39PHE A 91MET A 94LEU A 148 | 3AM A 338 (-4.5A)3AM A 338 ( 4.1A)3AM A 338 (-3.3A)3AM A 338 (-3.6A)None3AM A 338 (-4.7A) | 0.83A | 2y7jD-3c0iA:32.5 | 2y7jD-3c0iA:28.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3MIY_A_B49A1_1 (TYROSINE-PROTEINKINASE ITK/TSK) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 6 / 11 | ILE A 18ALA A 39LYS A 41PHE A 91PHE A 93MET A 94 | 3AM A 338 (-4.5A)3AM A 338 (-3.3A)3AM A 338 (-2.9A)3AM A 338 (-3.6A)3AM A 338 ( 4.6A)None | 0.81A | 3miyA-3c0iA:24.3 | 3miyA-3c0iA:26.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3MIY_B_B49B2_1 (TYROSINE-PROTEINKINASE ITK/TSK) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 5 / 9 | ILE A 18ALA A 39PHE A 91PHE A 93MET A 94 | 3AM A 338 (-4.5A)3AM A 338 (-3.3A)3AM A 338 (-3.6A)3AM A 338 ( 4.6A)None | 0.58A | 3miyB-3c0iA:24.0 | 3miyB-3c0iA:26.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3MIY_B_B49B2_1 (TYROSINE-PROTEINKINASE ITK/TSK) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 6 / 9 | ILE A 18ALA A 39PHE A 93MET A 94GLY A 96LEU A 148 | 3AM A 338 (-4.5A)3AM A 338 (-3.3A)3AM A 338 ( 4.6A)NoneNone3AM A 338 (-4.7A) | 1.26A | 3miyB-3c0iA:24.0 | 3miyB-3c0iA:26.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TI1_A_B49A299_1 (CYCLIN-DEPENDENTKINASE 2) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 6 / 9 | ILE A 18ALA A 39VAL A 75PHE A 91PHE A 93LEU A 148 | 3AM A 338 (-4.5A)3AM A 338 (-3.3A)None3AM A 338 (-3.6A)3AM A 338 ( 4.6A)3AM A 338 (-4.7A) | 0.60A | 3ti1A-3c0iA:23.9 | 3ti1A-3c0iA:28.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KS8_A_B49A701_1 (SERINE/THREONINE-PROTEIN KINASE PAK 6) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 6 / 10 | ILE A 18ALA A 39VAL A 75PHE A 93GLY A 96LEU A 148 | 3AM A 338 (-4.5A)3AM A 338 (-3.3A)None3AM A 338 ( 4.6A)None3AM A 338 (-4.7A) | 1.14A | 4ks8A-3c0iA:29.9 | 4ks8A-3c0iA:29.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L9I_A_8PRA601_1 (RHODOPSIN KINASE) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 4 / 7 | ALA A 39MET A 94ASP A 98LEU A 148 | 3AM A 338 (-3.3A)NoneNone3AM A 338 (-4.7A) | 0.58A | 4l9iA-3c0iA:11.9 | 4l9iA-3c0iA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L9I_A_8PRA601_1 (RHODOPSIN KINASE) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 4 / 7 | VAL A 26ALA A 39MET A 94LEU A 148 | 3AM A 338 ( 4.1A)3AM A 338 (-3.3A)None3AM A 338 (-4.7A) | 0.76A | 4l9iA-3c0iA:11.9 | 4l9iA-3c0iA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4WA9_B_AXIB9000_1 (TYROSINE-PROTEINKINASE ABL1) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 7 / 12 | VAL A 26ALA A 39LYS A 41PHE A 93MET A 94GLY A 96LEU A 148 | 3AM A 338 ( 4.1A)3AM A 338 (-3.3A)3AM A 338 (-2.9A)3AM A 338 ( 4.6A)NoneNone3AM A 338 (-4.7A) | 0.89A | 4wa9B-3c0iA:25.5 | 4wa9B-3c0iA:25.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5C0O_G_SAMG301_1 (TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASETRMI) |
3ago | RIBONUCLEASE U2 (Ustilagosphaerogena) | 3 / 3 | GLU A 62HIS A 41ASP A 108 | 3AM A 115 (-2.9A)3AM A 115 (-3.8A)3AM A 115 (-2.9A) | 0.49A | 5c0oG-3agoA:undetectable | 5c0oG-3agoA:15.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IZJ_G_AZ1G2_1 (CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA47P-AZ1-DAR-DAR) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 4 / 7 | GLY A 19GLY A 21VAL A 26LYS A 41 | NoneNone3AM A 338 ( 4.1A)3AM A 338 (-2.9A) | 0.22A | 5izjA-3c0iA:21.8 | 5izjA-3c0iA:28.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5J5X_B_AZ1B2_1 (CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA47P-AZ1-DAL-DAR-DAR-DAR-DAR) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 4 / 7 | GLY A 19GLY A 21VAL A 26LYS A 41 | NoneNone3AM A 338 ( 4.1A)3AM A 338 (-2.9A) | 0.25A | 5j5xA-3c0iA:20.3 | 5j5xA-3c0iA:28.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5L2I_A_LQQA900_1 (CYCLIN-DEPENDENTKINASE 6) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 7 / 12 | ILE A 18GLY A 19VAL A 26ALA A 39VAL A 75PHE A 91LEU A 148 | 3AM A 338 (-4.5A)None3AM A 338 ( 4.1A)3AM A 338 (-3.3A)None3AM A 338 (-3.6A)3AM A 338 (-4.7A) | 0.68A | 5l2iA-3c0iA:7.7 | 5l2iA-3c0iA:26.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5L2T_A_6ZZA900_1 (CYCLIN-DEPENDENTKINASE 6) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 7 / 12 | ILE A 18GLY A 19VAL A 26ALA A 39VAL A 75PHE A 91LEU A 148 | 3AM A 338 (-4.5A)None3AM A 338 ( 4.1A)3AM A 338 (-3.3A)None3AM A 338 (-3.6A)3AM A 338 (-4.7A) | 1.12A | 5l2tA-3c0iA:7.8 | 5l2tA-3c0iA:26.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5LW1_B_ADNB401_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 8) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 5 / 9 | ILE A 18GLY A 19VAL A 26ALA A 39MET A 94 | 3AM A 338 (-4.5A)None3AM A 338 ( 4.1A)3AM A 338 (-3.3A)None | 0.59A | 5lw1B-3c0iA:23.2 | 5lw1B-3c0iA:12.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5TE0_A_XINA401_1 (AP2-ASSOCIATEDPROTEIN KINASE 1) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 6 / 12 | GLU A 16ALA A 39VAL A 75PHE A 93GLY A 96LEU A 148 | None3AM A 338 (-3.3A)None3AM A 338 ( 4.6A)None3AM A 338 (-4.7A) | 0.84A | 5te0A-3c0iA:27.7 | 5te0A-3c0iA:27.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HD4_A_STIA604_1 (TYROSINE-PROTEINKINASE ABL1) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 4 / 5 | VAL A 165PHE A 93MET A 94GLY A 96 | None3AM A 338 ( 4.6A)NoneNone | 0.61A | 6hd4A-3c0iA:23.0 | 6hd4A-3c0iA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HD4_B_STIB602_1 (TYROSINE-PROTEINKINASE ABL1) |
3c0i | PERIPHERAL PLASMAMEMBRANE PROTEINCASK (Homosapiens) | 4 / 6 | VAL A 165PHE A 93MET A 94GLY A 96 | None3AM A 338 ( 4.6A)NoneNone | 0.64A | 6hd4B-3c0iA:23.2 | 6hd4B-3c0iA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6MN4_A_AM2A301_0 (AMINOGLYCOSIDEN(3)-ACETYLTRANSFERASE, AAC(3)-IVA) |
3ago | RIBONUCLEASE U2 (Ustilagosphaerogena) | 4 / 8 | ASP A 84HIS A 41GLU A 62GLU A 49 | None3AM A 115 (-3.8A)3AM A 115 (-2.9A)3AM A 115 (-2.8A) | 1.03A | 6mn4A-3agoA:undetectable | 6mn4A-3agoA:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6MN4_B_AM2B301_0 (AMINOGLYCOSIDEN(3)-ACETYLTRANSFERASE, AAC(3)-IVA) |
3ago | RIBONUCLEASE U2 (Ustilagosphaerogena) | 4 / 8 | ASP A 84HIS A 41GLU A 62GLU A 49 | None3AM A 115 (-3.8A)3AM A 115 (-2.9A)3AM A 115 (-2.8A) | 1.11A | 6mn4B-3agoA:undetectable | 6mn4B-3agoA:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6MN4_D_AM2D301_0 (AMINOGLYCOSIDEN(3)-ACETYLTRANSFERASE, AAC(3)-IVA) |
3ago | RIBONUCLEASE U2 (Ustilagosphaerogena) | 4 / 8 | ASP A 84HIS A 41GLU A 62GLU A 49 | None3AM A 115 (-3.8A)3AM A 115 (-2.9A)3AM A 115 (-2.8A) | 1.06A | 6mn4D-3agoA:undetectable | 6mn4D-3agoA:16.86 |