SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '39G'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		5 / 12 VAL B 102
LEU B  55
LEU B  75
LEU B 104
LEU B  74
 None
None
39G  B 401 (-4.3A)
39G  B 401 ( 4.7A)
None
 0.93A 1mx1C-4tyhB:
undetectable		 1mx1C-4tyhB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		5 / 12 VAL B 102
LEU B  55
LEU B  75
LEU B 104
LEU B  74
 None
None
39G  B 401 (-4.3A)
39G  B 401 ( 4.7A)
None
 1.06A 1mx1F-4tyhB:
undetectable		 1mx1F-4tyhB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		6 / 9 VAL B  38
LYS B  53
LEU B  86
LEU B 104
LEU B 108
MET B 109
 None
39G  B 401 (-4.2A)
None
39G  B 401 ( 4.7A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
 0.68A 1xkkA-4tyhB:
20.6		 1xkkA-4tyhB:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		3 / 3 LEU B 104
LEU B 108
MET B 109
 39G  B 401 ( 4.7A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
 0.51A 2itzA-4tyhB:
21.7		 2itzA-4tyhB:
25.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		6 / 12 GLU B  71
LEU B  74
LEU B  75
THR B 106
LEU B 167
ASP B 168
 39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
 1.26A 3gcsA-4tyhB:
29.9		 3gcsA-4tyhB:
98.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		5 / 12 LEU B  75
ILE B  84
THR B 106
LEU B 167
ASP B 168
 39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
 0.95A 3gcsA-4tyhB:
29.9		 3gcsA-4tyhB:
98.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		9 / 12 VAL B  38
ALA B  51
GLU B  71
LEU B  74
LEU B  75
THR B 106
ILE B 141
HIS B 148
LEU B 167
 None
39G  B 401 (-3.5A)
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
39G  B 401 (-3.6A)
None
None
39G  B 401 (-3.6A)
 0.95A 3gcsA-4tyhB:
29.9		 3gcsA-4tyhB:
98.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		8 / 12 VAL B  38
ALA B  51
LEU B  75
ILE B  84
THR B 106
ILE B 141
HIS B 148
LEU B 167
 None
39G  B 401 (-3.5A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
None
39G  B 401 (-3.6A)
 0.81A 3gcsA-4tyhB:
29.9		 3gcsA-4tyhB:
98.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		5 / 6 MET B  78
VAL B  83
LEU B 108
ILE B 146
ILE B 166
 None
None
39G  B 401 ( 4.9A)
None
None
 0.62A 3gcsA-4tyhB:
29.9		 3gcsA-4tyhB:
98.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		5 / 6 MET B  78
VAL B  83
LEU B 108
MET B 109
ILE B 166
 None
None
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
None
 1.07A 3gcsA-4tyhB:
29.9		 3gcsA-4tyhB:
98.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		8 / 12 ALA B  51
GLU B  71
LEU B  74
LEU B  75
ILE B  84
ALA B 157
LEU B 167
ASP B 168
 39G  B 401 (-3.5A)
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
 1.08A 3gp0A-4tyhB:
41.1		 3gp0A-4tyhB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		8 / 12 ALA B  51
GLU B  71
LEU B  74
LEU B  75
ILE B  84
HIS B 148
ALA B 157
LEU B 167
 39G  B 401 (-3.5A)
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
None
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
 0.85A 3gp0A-4tyhB:
41.1		 3gp0A-4tyhB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		9 / 12 VAL B  38
ALA B  51
LEU B  74
LEU B  75
ILE B  84
THR B 106
ALA B 157
LEU B 167
ASP B 168
 None
39G  B 401 (-3.5A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
 0.98A 3gp0A-4tyhB:
41.1		 3gp0A-4tyhB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		9 / 12 VAL B  38
ALA B  51
LEU B  74
LEU B  75
ILE B  84
THR B 106
HIS B 148
ALA B 157
LEU B 167
 None
39G  B 401 (-3.5A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
 0.90A 3gp0A-4tyhB:
41.1		 3gp0A-4tyhB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		5 / 12 GLU B  71
LEU B  75
ILE B  84
LEU B 167
ASP B 168
 39G  B 401 (-3.4A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
 0.79A 3hecA-4tyhB:
41.0		 3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		5 / 12 LEU B  75
ILE B  84
THR B 106
LEU B 167
ASP B 168
 39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
 0.81A 3hecA-4tyhB:
41.0		 3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		6 / 12 LYS B  53
ILE B  84
THR B 106
LEU B 108
LEU B 167
ASP B 168
 39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
 0.85A 3hecA-4tyhB:
41.0		 3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		7 / 12 VAL B  30
ALA B  51
LEU B  74
ILE B  84
THR B 106
LEU B 108
LEU B 167
 None
39G  B 401 (-3.5A)
None
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
 0.59A 3hecA-4tyhB:
41.0		 3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		7 / 12 VAL B  30
ALA B  51
LEU B  74
LEU B  75
ILE B  84
THR B 106
LEU B 167
 None
39G  B 401 (-3.5A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
 0.63A 3hecA-4tyhB:
41.0		 3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		7 / 12 VAL B  30
ALA B  51
LYS B  53
ILE B  84
THR B 106
LEU B 108
LEU B 167
 None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
 0.65A 3hecA-4tyhB:
41.0		 3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		6 / 12 VAL B  30
GLU B  71
LEU B  74
LEU B  75
ILE B  84
LEU B 167
 None
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
 0.66A 3hecA-4tyhB:
41.0		 3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		7 / 12 VAL B  30
VAL B  38
ALA B  51
GLU B  71
LEU B  74
LEU B  75
ILE B 141
 None
None
39G  B 401 (-3.5A)
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
None
 0.84A 3hegA-4tyhB:
42.1		 3hegA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		7 / 12 VAL B  30
VAL B  38
ALA B  51
LEU B  74
LEU B  75
THR B 106
ILE B 141
 None
None
39G  B 401 (-3.5A)
None
39G  B 401 (-4.3A)
39G  B 401 (-3.6A)
None
 0.69A 3hegA-4tyhB:
42.1		 3hegA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		7 / 12 VAL B  30
VAL B  38
ALA B  51
LEU B  75
ILE B  84
THR B 106
ILE B 141
 None
None
39G  B 401 (-3.5A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
 0.57A 3hegA-4tyhB:
42.1		 3hegA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		6 / 12 VAL B  38
ALA B  51
LYS B  53
ILE B  84
THR B 106
ILE B 141
 None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
 0.84A 3hegA-4tyhB:
42.1		 3hegA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		6 / 6 MET B  78
VAL B  83
ILE B 146
HIS B 148
ILE B 166
LEU B 167
 None
None
None
None
None
39G  B 401 (-3.6A)
 0.63A 3hegA-4tyhB:
42.1		 3hegA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		5 / 8 ALA B  51
LYS B  53
THR B 106
LEU B 108
MET B 109
 39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
 0.61A 3lfaA-4tyhB:
42.6		 3lfaA-4tyhB:
99.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		6 / 8 VAL B  30
ALA B  51
LEU B 104
THR B 106
LEU B 108
MET B 109
 None
39G  B 401 (-3.5A)
39G  B 401 ( 4.7A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
 0.54A 3lfaA-4tyhB:
42.6		 3lfaA-4tyhB:
99.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		5 / 12 VAL B  38
ALA B  51
LYS B  53
LEU B  75
THR B 106
 None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 (-4.3A)
39G  B 401 (-3.6A)
 0.70A 3og7A-4tyhB:
19.2		 3og7A-4tyhB:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		7 / 12 GLY B  31
VAL B  38
ALA B  51
LEU B  75
ILE B  84
THR B 106
ASN B 114
 None
None
39G  B 401 (-3.5A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
 1.46A 3ohtA-4tyhB:
34.3		 3ohtA-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		9 / 12 VAL B  30
GLY B  31
VAL B  38
ALA B  51
LYS B  53
LEU B  75
ILE B  84
THR B 106
LEU B 167
 None
None
None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
 0.86A 3ohtA-4tyhB:
34.3		 3ohtA-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		7 / 12 VAL B  30
GLY B  31
VAL B  38
LYS B  53
ILE B  84
LEU B 167
ASP B 168
 None
None
None
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
 1.21A 3ohtA-4tyhB:
34.3		 3ohtA-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		9 / 12 VAL B  30
VAL B  38
ALA B  51
LYS B  53
LEU B  75
ILE B  84
THR B 106
ASN B 115
LEU B 167
 None
None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
39G  B 401 (-3.6A)
 0.86A 3ohtA-4tyhB:
34.3		 3ohtA-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_1
(P38A)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		7 / 12 GLY B  31
VAL B  38
ALA B  51
LYS B  53
ILE B  84
THR B 106
LEU B 167
 None
None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
 0.77A 3ohtB-4tyhB:
34.3		 3ohtB-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_1
(P38A)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		5 / 12 VAL B  38
ALA B  51
LEU B  75
ILE B  84
LEU B 167
 None
39G  B 401 (-3.5A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
 0.45A 3ohtB-4tyhB:
34.3		 3ohtB-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_1
(P38A)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		6 / 12 VAL B  38
ALA B  51
LYS B  53
ILE B  84
THR B 106
ASN B 115
 None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
 0.85A 3ohtB-4tyhB:
34.3		 3ohtB-4tyhB:
86.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		4 / 4 SER B  56
ASP B 168
ASP B 112
ALA B  34
 None
39G  B 401 (-3.5A)
None
None
 1.37A 3uj6A-4tyhB:
undetectable		 3uj6A-4tyhB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		5 / 10 ALA B  51
LYS B  53
ILE B  84
THR B 106
LEU B 108
 39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
 0.83A 4rz7A-4tyhB:
17.6		 4rz7A-4tyhB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		4 / 7 VAL B  38
LYS B  53
ILE B  84
ILE B 166
 None
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
None
 0.79A 4uxqA-4tyhB:
21.3		 4uxqA-4tyhB:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		4 / 8 LEU B  75
LEU B 167
TYR B 140
GLN B 202
 39G  B 401 (-4.3A)
39G  B 401 (-3.6A)
None
None
 1.19A 5hbsA-4tyhB:
undetectable		 5hbsA-4tyhB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		5 / 10 GLY B  31
VAL B  38
ALA B  51
LEU B 108
MET B 109
 None
None
39G  B 401 (-3.5A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
 0.77A 5lw1E-4tyhB:
36.8		 5lw1E-4tyhB:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		5 / 9 GLY B  31
ALA B  51
LEU B 108
MET B 109
LEU B 167
 None
39G  B 401 (-3.5A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
39G  B 401 (-3.6A)
 0.80A 5lw1H-4tyhB:
15.5		 5lw1H-4tyhB:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14
(Mus
musculus) 		5 / 9 GLY B  31
VAL B  38
ALA B  51
LEU B 108
MET B 109
 None
None
39G  B 401 (-3.5A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
 0.77A 5lw1H-4tyhB:
15.5		 5lw1H-4tyhB:
11.21