SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '38R'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		7 / 12 GLY A  11
VAL A  18
ALA A  31
VAL A  63
ASN A 130
LEU A 132
ASP A 143
 38R  A 350 ( 3.9A)
38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
NA  A 353 ( 2.5A)
 0.75A 1fmoE-3zduA:
25.5		 1fmoE-3zduA:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  50
VAL A  63
PHE A  81
LEU A 132
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 ( 4.8A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
 0.49A 1opjA-3zduA:
22.3		 1opjA-3zduA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 ALA A  31
LYS A  33
GLU A  50
LEU A  54
LEU A 116
HIS A 123
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
None
None
 0.81A 1uwhB-3zduA:
22.9		 1uwhB-3zduA:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		7 / 12 VAL A  18
LYS A  33
VAL A  63
PHE A  79
ASN A 130
LEU A 132
ASP A 143
 38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.1A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
NA  A 353 ( 2.5A)
 0.60A 2eufB-3zduA:
29.7		 2eufB-3zduA:
35.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		6 / 12 VAL A  27
LYS A  42
VAL A  73
PHE A  89
VAL A  92
LEU A 142
 38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
None
38R  A1000 ( 3.8A)
38R  A1000 (-4.1A)
38R  A1000 ( 4.5A)
 0.44A 2eufB-4bgqA:
30.6		 2eufB-4bgqA:
35.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		6 / 11 VAL A  19
GLY A  20
VAL A  27
ALA A  40
TYR A  91
LEU A 142
 38R  A1000 (-4.7A)
None
38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
38R  A1000 (-4.8A)
38R  A1000 ( 4.5A)
 0.47A 2evaA-4bgqA:
23.4		 2evaA-4bgqA:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 VAL A  18
ALA A  31
GLU A  50
VAL A  63
PHE A  81
LEU A 132
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 ( 4.8A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
 0.54A 2hyyC-3zduA:
22.6		 2hyyC-3zduA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		7 / 12 GLY A  11
VAL A  18
LYS A  33
GLU A  50
LEU A  54
LEU A  77
LEU A 132
 38R  A 350 ( 3.9A)
38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
None
38R  A 350 (-4.3A)
 0.62A 2ivuA-3zduA:
25.0		 2ivuA-3zduA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		7 / 12 GLY A  11
ALA A  31
LYS A  33
VAL A  63
PHE A  81
LEU A 132
CYH A 142
 38R  A 350 ( 3.9A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
38R  A 350 ( 3.9A)
 0.69A 3c7qA-3zduA:
21.5		 3c7qA-3zduA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 ALA A  31
GLU A  50
LEU A  62
PHE A  81
HIS A 123
 38R  A 350 (-3.4A)
38R  A 350 ( 4.8A)
None
38R  A 350 (-4.2A)
None
 0.72A 3cs9C-3zduA:
22.4		 3cs9C-3zduA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 LEU A  54
GLU A  50
ASP A 143
LEU A 116
PHE A  79
 None
38R  A 350 ( 4.8A)
NA  A 353 ( 2.5A)
None
38R  A 350 (-4.1A)
 1.37A 3g1uC-3zduA:
undetectable		 3g1uC-3zduA:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 VAL A  10
ALA A  31
LYS A  33
GLU A  50
LEU A  54
 38R  A 350 (-4.4A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
 0.72A 3hecA-3zduA:
21.9		 3hecA-3zduA:
33.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 VAL A  10
VAL A  18
ALA A  31
LYS A  33
GLU A  50
LEU A  54
 38R  A 350 (-4.4A)
38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
 0.87A 3hegA-3zduA:
25.3		 3hegA-3zduA:
33.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 ALA A  31
LEU A  62
VAL A  63
HIS A 123
LEU A 132
 38R  A 350 (-3.4A)
None
38R  A 350 ( 4.9A)
None
38R  A 350 (-4.3A)
 0.60A 3ik3A-3zduA:
16.5		 3ik3A-3zduA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 ALA A  31
LEU A  62
VAL A  63
HIS A 123
LEU A 132
 38R  A 350 (-3.4A)
None
38R  A 350 ( 4.9A)
None
38R  A 350 (-4.3A)
 0.64A 3ik3B-3zduA:
22.0		 3ik3B-3zduA:
28.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 8 VAL A  10
ALA A  31
LYS A  33
GLU A  50
LEU A  77
 38R  A 350 (-4.4A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
 0.52A 3lfaA-3zduA:
25.3		 3lfaA-3zduA:
33.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		7 / 12 GLY A  20
VAL A  27
ALA A  40
LYS A  42
TYR A  91
VAL A  92
LEU A 142
 None
38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
38R  A1000 (-3.4A)
38R  A1000 (-4.8A)
38R  A1000 (-4.1A)
38R  A1000 ( 4.5A)
 0.58A 3lxnA-4bgqA:
23.7		 3lxnA-4bgqA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 11 ALA A  31
LYS A  33
VAL A  63
PHE A  79
PHE A  81
LEU A 132
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.1A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
 0.64A 3miyA-3zduA:
24.2		 3miyA-3zduA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 VAL A  10
GLY A  11
VAL A  18
ALA A  31
LYS A  33
LEU A  54
 38R  A 350 (-4.4A)
38R  A 350 ( 3.9A)
38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
None
 0.81A 3ohtA-3zduA:
6.6		 3ohtA-3zduA:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		7 / 12 VAL A  18
ALA A  31
GLU A  50
LEU A  54
PHE A  79
LEU A 116
HIS A 123
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 ( 4.8A)
None
38R  A 350 (-4.1A)
None
None
 0.74A 3rgfA-3zduA:
12.1		 3rgfA-3zduA:
28.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 9 ALA A  31
VAL A  63
PHE A  79
PHE A  81
LEU A 132
 38R  A 350 (-3.4A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.1A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
 0.55A 3ti1A-3zduA:
28.8		 3ti1A-3zduA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 9 VAL A  63
PHE A  79
PHE A  81
LEU A 132
ASP A 143
 38R  A 350 ( 4.9A)
38R  A 350 (-4.1A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
NA  A 353 ( 2.5A)
 0.96A 3ti1A-3zduA:
28.8		 3ti1A-3zduA:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 GLY A  13
GLY A  16
VAL A  18
ALA A  31
LYS A  33
ASP A 143
 None
None
38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
NA  A 353 ( 2.5A)
 0.77A 3v5wA-3zduA:
7.8		 3v5wA-3zduA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 8 VAL A  18
LYS A  33
PHE A  79
ASP A 143
 38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 (-4.1A)
NA  A 353 ( 2.5A)
 0.52A 3warA-3zduA:
28.6		 3warA-3zduA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		8 / 12 VAL A  18
ALA A  31
LYS A  33
GLU A  50
LEU A  54
PHE A  81
LEU A 116
HIS A 123
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
38R  A 350 (-4.2A)
None
None
 0.68A 3wzeA-3zduA:
22.2		 3wzeA-3zduA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 8 VAL A  63
LEU A 132
CYH A 142
ASP A 143
 38R  A 350 ( 4.9A)
38R  A 350 (-4.3A)
38R  A 350 ( 3.9A)
NA  A 353 ( 2.5A)
 0.62A 3wzeA-3zduA:
22.2		 3wzeA-3zduA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		8 / 12 VAL A  18
ALA A  31
LYS A  33
GLU A  50
VAL A  63
PHE A  81
LEU A 132
CYH A 142
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
38R  A 350 ( 3.9A)
 0.65A 4ag8A-3zduA:
22.2		 4ag8A-3zduA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		8 / 12 VAL A  18
ALA A  31
LYS A  33
GLU A  50
LEU A  54
PHE A  81
LEU A 116
HIS A 123
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
38R  A 350 (-4.2A)
None
None
 0.79A 4asdA-3zduA:
7.2		 4asdA-3zduA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		7 / 12 ALA A  40
LYS A  42
LEU A  64
ILE A  72
HIS A 133
LEU A 142
ASP A 153
 38R  A1000 (-3.4A)
38R  A1000 (-3.4A)
None
None
None
38R  A1000 ( 4.5A)
38R  A1000 ( 4.2A)
 1.06A 4c8bB-4bgqA:
22.4		 4c8bB-4bgqA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 6 VAL A  18
ALA A  31
THR A  85
LEU A 132
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
 0.66A 4o0uA-3zduA:
8.5		 4o0uA-3zduA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 LEU A  54
GLU A  50
ASP A 143
LEU A 116
PHE A  79
 None
38R  A 350 ( 4.8A)
NA  A 353 ( 2.5A)
None
38R  A 350 (-4.1A)
 1.35A 4pgfA-3zduA:
undetectable		 4pgfA-3zduA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 ALA A  31
LYS A  33
LEU A  54
HIS A 123
LEU A 132
CYH A 142
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
None
None
38R  A 350 (-4.3A)
38R  A 350 ( 3.9A)
 0.49A 4u0iA-3zduA:
22.4		 4u0iA-3zduA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 ALA A  31
LYS A  33
LEU A  54
ASP A 143
PHE A 144
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
None
NA  A 353 ( 2.5A)
None
 0.80A 4xv2B-3zduA:
23.1		 4xv2B-3zduA:
28.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 VAL A  18
ALA A  31
LYS A  33
LEU A  54
PHE A 144
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
None
None
 0.82A 5cswA-3zduA:
22.8		 5cswA-3zduA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		6 / 12 ALA A  31
LYS A  33
GLU A  50
LEU A  54
LEU A 116
HIS A 123
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
None
None
 0.90A 5hi2A-3zduA:
23.1		 5hi2A-3zduA:
28.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 7 GLY A  11
GLY A  13
GLY A  16
VAL A  18
 38R  A 350 ( 3.9A)
None
None
38R  A 350 ( 4.8A)
 0.33A 5izjB-3zduA:
24.4		 5izjB-3zduA:
31.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 7 GLY A  11
GLY A  13
VAL A  18
LYS A  33
 38R  A 350 ( 3.9A)
None
38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
 0.29A 5izjA-3zduA:
24.9		 5izjA-3zduA:
31.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 7 GLY A  11
GLY A  13
VAL A  18
LYS A  33
ASP A 143
 38R  A 350 ( 3.9A)
None
38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
NA  A 353 ( 2.5A)
 0.54A 5j5xA-3zduA:
25.3		 5j5xA-3zduA:
31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 7 GLY A  20
GLY A  22
VAL A  27
LYS A  42
 None
None
38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
 0.44A 5j5xA-4bgqA:
25.2		 5j5xA-4bgqA:
25.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		7 / 12 GLY A  11
TYR A  15
VAL A  18
ALA A  31
VAL A  63
PHE A  79
LEU A 132
 38R  A 350 ( 3.9A)
None
38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.1A)
38R  A 350 (-4.3A)
 0.79A 5l2iA-3zduA:
12.4		 5l2iA-3zduA:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		7 / 12 GLY A  20
TYR A  24
VAL A  27
ALA A  40
VAL A  73
PHE A  89
LEU A 142
 None
38R  A1000 (-3.6A)
38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
None
38R  A1000 ( 3.8A)
38R  A1000 ( 4.5A)
 0.85A 5l2iA-4bgqA:
16.7		 5l2iA-4bgqA:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		6 / 12 GLY A  20
VAL A  27
ALA A  40
VAL A  73
PHE A  89
LEU A 142
 None
38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
None
38R  A1000 ( 3.8A)
38R  A1000 ( 4.5A)
 0.68A 5l2tA-4bgqA:
17.1		 5l2tA-4bgqA:
35.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 ALA A  31
LEU A  62
VAL A  63
HIS A 123
LEU A 132
 38R  A 350 (-3.4A)
None
38R  A 350 ( 4.9A)
None
38R  A 350 (-4.3A)
 0.63A 5mo4A-3zduA:
16.5		 5mo4A-3zduA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		6 / 10 VAL A  27
ALA A  40
VAL A  73
TYR A  91
VAL A  92
LEU A 142
 38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
None
38R  A1000 (-4.8A)
38R  A1000 (-4.1A)
38R  A1000 ( 4.5A)
 0.44A 5n3hA-4bgqA:
25.6		 5n3hA-4bgqA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		4 / 4 VAL A  27
LYS A  42
VAL A  73
ASN A 140
 38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
None
None
 0.99A 5vc3A-4bgqA:
26.3		 5vc3A-4bgqA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		7 / 12 ALA A  31
LYS A  33
GLU A  50
LEU A  77
LEU A 132
CYH A 142
ASP A 143
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
38R  A 350 (-4.3A)
38R  A 350 ( 3.9A)
NA  A 353 ( 2.5A)
 0.91A 5y7zB-3zduA:
23.8		 5y7zB-3zduA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 8 VAL A  18
LYS A  33
PHE A  79
ASP A 143
 38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 (-4.1A)
NA  A 353 ( 2.5A)
 0.35A 5y9mX-3zduA:
26.8		 5y9mX-3zduA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 7 VAL A  18
LYS A  33
PHE A  79
ASP A 143
 38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 (-4.1A)
NA  A 353 ( 2.5A)
 0.50A 5yf9B-3zduA:
26.7		 5yf9B-3zduA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		4 / 7 VAL A  18
LYS A  33
PHE A  79
ASP A 143
 38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 (-4.1A)
NA  A 353 ( 2.5A)
 0.47A 5ywmX-3zduA:
26.8		 5ywmX-3zduA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		3 / 3 LYS A  42
LEU A 142
ASP A 153
 38R  A1000 (-3.4A)
38R  A1000 ( 4.5A)
38R  A1000 ( 4.2A)
 0.80A 5zv2A-4bgqA:
17.1		 5zv2A-4bgqA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens) 		3 / 3 TYR A  91
LEU A 142
ASP A 153
 38R  A1000 (-4.8A)
38R  A1000 ( 4.5A)
38R  A1000 ( 4.2A)
 0.80A 5zv2B-4bgqA:
17.6		 5zv2B-4bgqA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 LEU A  54
GLU A  50
ASP A 143
LEU A 116
PHE A  79
 None
38R  A 350 ( 4.8A)
NA  A 353 ( 2.5A)
None
38R  A 350 (-4.1A)
 1.33A 6aphA-3zduA:
undetectable		 6aphA-3zduA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 LEU A  54
GLU A  50
ASP A 143
LEU A 116
PHE A  79
 None
38R  A 350 ( 4.8A)
NA  A 353 ( 2.5A)
None
38R  A 350 (-4.1A)
 1.43A 6gbnB-3zduA:
undetectable		 6gbnB-3zduA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_1
(-)		 3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens) 		5 / 12 LEU A  54
GLU A  50
ASP A 143
LEU A 116
PHE A  79
 None
38R  A 350 ( 4.8A)
NA  A 353 ( 2.5A)
None
38R  A 350 (-4.1A)
 1.44A 6gbnC-3zduA:
undetectable		 6gbnC-3zduA:
21.18