SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '38O'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.66A 1iepA-5a46A:
30.8		 1iepA-5a46A:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-3.4A)
EDO  A1766 ( 4.4A)
 0.72A 1iepB-5a46A:
30.5		 1iepB-5a46A:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.61A 1m17A-5a46A:
31.0		 1m17A-5a46A:
33.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 9 LEU A 484
GLY A 485
VAL A 492
ALA A 512
TYR A 563
ALA A 564
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
38O  A1769 (-4.6A)
 0.67A 1muoA-5a46A:
7.8		 1muoA-5a46A:
26.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.67A 1opjA-5a46A:
30.5		 1opjA-5a46A:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-3.4A)
EDO  A1766 ( 4.4A)
 0.73A 1opjB-5a46A:
30.5		 1opjB-5a46A:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.49A 1t46A-5a46A:
27.9		 1t46A-5a46A:
43.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		5 / 12 VAL A 492
ALA A 512
GLU A 531
LEU A 614
HIS A 621
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
None
 0.46A 1uwjA-5a46A:
7.4		 1uwjA-5a46A:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		5 / 12 VAL A 492
ALA A 512
GLU A 531
LEU A 614
HIS A 621
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
None
 0.46A 1uwjB-5a46A:
7.4		 1uwjB-5a46A:
25.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 9 LEU A 484
VAL A 492
ALA A 512
ALA A 564
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-3.9A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.58A 1xbbA-5a46A:
25.5		 1xbbA-5a46A:
31.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 11 GLY A 485
VAL A 492
ALA A 512
TYR A 563
ALA A 564
LEU A 630
ASP A 641
 38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.67A 2evaA-5a46A:
26.2		 2evaA-5a46A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 LEU A 484
VAL A 492
ALA A 512
TYR A 563
ASN A 628
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
None
38O  A1769 (-4.0A)
 0.82A 2fumC-5a46A:
23.7		 2fumC-5a46A:
25.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
ALA A 512
LYS A 514
GLU A 531
MET A 535
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.94A 2gqgA-5a46A:
30.8		 2gqgA-5a46A:
38.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.51A 2gqgB-5a46A:
30.4		 2gqgB-5a46A:
38.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.77A 2hyyA-5a46A:
30.7		 2hyyA-5a46A:
40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.83A 2hyyB-5a46A:
31.0		 2hyyB-5a46A:
40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLU A 531
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.72A 2hyyC-5a46A:
30.6		 2hyyC-5a46A:
40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.76A 2hyyD-5a46A:
30.9		 2hyyD-5a46A:
40.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 LEU A 484
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.67A 2itoA-5a46A:
30.9		 2itoA-5a46A:
31.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		9 / 12 LEU A 484
GLY A 485
VAL A 492
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.83A 2ityA-5a46A:
30.8		 2ityA-5a46A:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.73A 2itzA-5a46A:
30.7		 2itzA-5a46A:
31.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
GLY A 485
VAL A 492
GLU A 531
VAL A 561
TYR A 563
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.3A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.62A 2ivuA-5a46A:
33.2		 2ivuA-5a46A:
44.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		9 / 12 LEU A 484
GLY A 485
VAL A 492
LYS A 514
GLU A 531
TYR A 563
ALA A 564
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.59A 2ivuA-5a46A:
33.2		 2ivuA-5a46A:
44.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.68A 2oiqA-5a46A:
31.0		 2oiqA-5a46A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 GLY A 485
VAL A 492
ALA A 512
TYR A 563
GLY A 567
ALA A 640
 38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
EDO  A1766 ( 4.4A)
 0.61A 2wgjA-5a46A:
31.3		 2wgjA-5a46A:
34.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 VAL A 492
ALA A 512
ILE A 545
GLY A 567
LEU A 630
ASP A 641
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.3A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.54A 2y7jA-5a46A:
23.5		 2y7jA-5a46A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 10 VAL A 492
ALA A 512
ILE A 545
GLY A 567
LEU A 630
ASP A 641
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.3A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.63A 2y7jB-5a46A:
23.8		 2y7jB-5a46A:
23.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
ALA A 512
LYS A 514
GLU A 531
MET A 535
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.77A 2zvaA-5a46A:
31.4		 2zvaA-5a46A:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLY A 567
LEU A 630
ASP A 641
PHE A 642
LEU A 644
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
EDO  A1766 (-3.7A)
None
 0.85A 3bbtB-5a46A:
27.2		 3bbtB-5a46A:
34.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLY A 567
LEU A 630
ASP A 641
PHE A 642
LEU A 644
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
EDO  A1766 (-3.7A)
None
 0.99A 3bbtD-5a46A:
28.1		 3bbtD-5a46A:
34.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
LYS A 514
GLY A 567
LEU A 630
ASP A 641
LEU A 644
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
None
 1.11A 3bbtD-5a46A:
28.1		 3bbtD-5a46A:
34.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
GLY A 485
ALA A 512
LYS A 514
VAL A 561
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-4.3A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.33A 3c7qA-5a46A:
35.2		 3c7qA-5a46A:
46.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 ALA A 512
GLU A 531
MET A 535
GLY A 567
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.62A 3cs9A-5a46A:
30.9		 3cs9A-5a46A:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 ALA A 512
GLU A 531
MET A 535
GLY A 567
HIS A 621
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
None
EDO  A1766 ( 4.4A)
 0.51A 3cs9B-5a46A:
30.9		 3cs9B-5a46A:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		5 / 12 ALA A 512
GLU A 531
MET A 535
ILE A 538
HIS A 621
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
None
 0.72A 3cs9B-5a46A:
30.9		 3cs9B-5a46A:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 ALA A 512
GLU A 531
MET A 535
ILE A 538
HIS A 621
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
None
EDO  A1766 ( 4.4A)
 0.68A 3cs9C-5a46A:
30.0		 3cs9C-5a46A:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 ALA A 512
GLU A 531
MET A 535
GLY A 567
HIS A 621
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
None
EDO  A1766 ( 4.4A)
 0.55A 3cs9D-5a46A:
29.7		 3cs9D-5a46A:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 ALA A 512
GLU A 531
MET A 535
ILE A 538
HIS A 621
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
None
EDO  A1766 ( 4.4A)
 0.72A 3cs9D-5a46A:
29.7		 3cs9D-5a46A:
38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 11 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.29A 3g0eA-5a46A:
32.5		 3g0eA-5a46A:
42.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 11 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.35A 3g0fA-5a46A:
33.7		 3g0fA-5a46A:
41.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 10 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.29A 3g0fB-5a46A:
33.8		 3g0fB-5a46A:
41.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		9 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.57A 3g5dA-5a46A:
30.5		 3g5dA-5a46A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		10 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.73A 3g5dB-5a46A:
30.8		 3g5dB-5a46A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.60A 3gvuA-5a46A:
25.3		 3gvuA-5a46A:
37.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 ALA A 512
GLU A 531
MET A 535
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.51A 3ik3A-5a46A:
30.5		 3ik3A-5a46A:
36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 ALA A 512
GLU A 531
MET A 535
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.52A 3ik3B-5a46A:
25.0		 3ik3B-5a46A:
36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.67A 3k54A-5a46A:
30.5		 3k54A-5a46A:
33.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.68A 3k5vA-5a46A:
30.5		 3k5vA-5a46A:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.71A 3k5vB-5a46A:
30.3		 3k5vB-5a46A:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
GLY A 485
VAL A 492
ALA A 512
ILE A 545
TYR A 563
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
 0.42A 3lxnA-5a46A:
28.2		 3lxnA-5a46A:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.75A 3ms9A-5a46A:
30.2		 3ms9A-5a46A:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		9 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.73A 3ms9B-5a46A:
30.4		 3ms9B-5a46A:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.80A 3mssA-5a46A:
30.4		 3mssA-5a46A:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
GLY A 567
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
EDO  A1766 ( 4.4A)
 0.57A 3mssB-5a46A:
30.4		 3mssB-5a46A:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
MET A 535
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.63A 3mssB-5a46A:
30.4		 3mssB-5a46A:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-3.4A)
EDO  A1766 ( 4.4A)
 0.68A 3mssB-5a46A:
30.4		 3mssB-5a46A:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.68A 3mssB-5a46A:
30.4		 3mssB-5a46A:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.82A 3mssC-5a46A:
30.4		 3mssC-5a46A:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.76A 3mssD-5a46A:
30.4		 3mssD-5a46A:
35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
MET A 535
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.59A 3octA-5a46A:
30.0		 3octA-5a46A:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.70A 3oezA-5a46A:
30.6		 3oezA-5a46A:
33.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.84A 3oezB-5a46A:
30.6		 3oezB-5a46A:
33.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		5 / 12 VAL A 492
ALA A 512
LYS A 514
PHE A 642
GLY A 643
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-3.7A)
EDO  A1766 (-3.6A)
 0.70A 3og7A-5a46A:
27.0		 3og7A-5a46A:
27.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 ALA A 512
GLU A 531
MET A 535
GLY A 567
HIS A 621
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
None
EDO  A1766 ( 4.4A)
 0.41A 3oxzA-5a46A:
25.2		 3oxzA-5a46A:
36.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
GLY A 567
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
EDO  A1766 ( 4.4A)
 0.72A 3pyyA-5a46A:
31.2		 3pyyA-5a46A:
35.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.59A 3pyyB-5a46A:
30.4		 3pyyB-5a46A:
35.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		9 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.69A 3qlgA-5a46A:
31.4		 3qlgA-5a46A:
33.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		10 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
38O  A1769 (-4.0A)
 0.64A 3qlgB-5a46A:
31.0		 3qlgB-5a46A:
33.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		9 / 12 VAL A 492
ALA A 512
GLU A 531
ILE A 545
TYR A 563
ALA A 564
LEU A 614
HIS A 621
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
None
None
EDO  A1766 ( 4.4A)
 0.88A 3rgfA-5a46A:
20.9		 3rgfA-5a46A:
24.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
MET A 535
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.54A 3sxrA-5a46A:
29.1		 3sxrA-5a46A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
MET A 535
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.53A 3sxrB-5a46A:
28.9		 3sxrB-5a46A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 LEU A 484
GLY A 485
ALA A 512
GLU A 531
VAL A 561
PHE A 642
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.3A)
EDO  A1766 (-3.7A)
 1.09A 3wzdA-5a46A:
34.6		 3wzdA-5a46A:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
VAL A 561
GLY A 567
LEU A 644
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.3A)
38O  A1769 (-3.4A)
None
 0.84A 3wzdA-5a46A:
34.6		 3wzdA-5a46A:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
VAL A 561
GLY A 567
PHE A 642
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.3A)
38O  A1769 (-3.4A)
EDO  A1766 (-3.7A)
 0.64A 3wzdA-5a46A:
34.6		 3wzdA-5a46A:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		10 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
ILE A 538
VAL A 561
GLY A 567
LEU A 614
HIS A 621
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
None
38O  A1769 (-4.3A)
38O  A1769 (-3.4A)
None
None
 0.67A 3wzeA-5a46A:
34.7		 3wzeA-5a46A:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		9 / 12 LEU A 484
ALA A 512
LYS A 514
GLU A 531
LEU A 614
HIS A 621
ARG A 622
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
None
None
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.65A 3zosA-5a46A:
30.7		 3zosA-5a46A:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		9 / 12 ALA A 512
LYS A 514
GLU A 531
ILE A 545
LEU A 614
HIS A 621
ARG A 622
LEU A 630
ALA A 640
 38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 ( 3.3A)
None
None
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.64A 3zosB-5a46A:
30.7		 3zosB-5a46A:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		5 / 9 LEU A 484
MET A 535
ILE A 544
TYR A 563
ILE A 639
 38O  A1769 (-3.2A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.2A)
None
 0.76A 3zosB-5a46A:
30.6		 3zosB-5a46A:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
VAL A 561
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.3A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.58A 4ag8A-5a46A:
27.9		 4ag8A-5a46A:
46.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
VAL A 561
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.3A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.60A 4agcA-5a46A:
34.6		 4agcA-5a46A:
45.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 11 LEU A 484
ALA A 512
LYS A 514
VAL A 561
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-4.3A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.49A 4agdA-5a46A:
34.7		 4agdA-5a46A:
45.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 9 LEU A 484
VAL A 492
ALA A 512
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.63A 4anqA-5a46A:
31.4		 4anqA-5a46A:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 9 LEU A 484
VAL A 492
ALA A 512
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.63A 4ansA-5a46A:
31.3		 4ansA-5a46A:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		9 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
VAL A 561
GLY A 567
LEU A 614
HIS A 621
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.3A)
38O  A1769 (-3.4A)
None
None
 0.54A 4asdA-5a46A:
25.8		 4asdA-5a46A:
45.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 545
TYR A 563
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 1.13A 4bkjA-5a46A:
30.5		 4bkjA-5a46A:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 545
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.96A 4bkjB-5a46A:
30.4		 4bkjB-5a46A:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 ALA A 512
LYS A 514
GLU A 531
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.41A 4c8bA-5a46A:
19.8		 4c8bA-5a46A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		4 / 5 VAL A 492
ILE A 544
TYR A 563
ILE A 639
 38O  A1769 (-4.5A)
None
38O  A1769 (-4.2A)
None
 0.64A 4c8bA-5a46A:
19.8		 4c8bA-5a46A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 ALA A 512
LYS A 514
GLU A 531
ILE A 544
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
None
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.67A 4c8bB-5a46A:
20.0		 4c8bB-5a46A:
25.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		9 / 10 LEU A 484
GLY A 485
GLY A 487
VAL A 492
ALA A 512
VAL A 561
TYR A 563
ALA A 564
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
None
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
38O  A1769 (-4.6A)
 0.43A 4ckjA-5a46A:
33.9		 4ckjA-5a46A:
44.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.60A 4csvA-5a46A:
31.4		 4csvA-5a46A:
36.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLY A 567
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.89A 4hjoA-5a46A:
29.4		 4hjoA-5a46A:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
GLY A 485
VAL A 492
ALA A 512
LYS A 514
GLY A 567
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.88A 4i22A-5a46A:
28.6		 4i22A-5a46A:
31.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 GLY A 485
VAL A 492
ALA A 512
LYS A 514
LEU A 547
GLY A 567
LEU A 630
 38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
None
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.59A 4ifgA-5a46A:
21.9		 4ifgA-5a46A:
22.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-4.0A)
 0.92A 4mxoA-5a46A:
30.7		 4mxoA-5a46A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
TYR A 563
GLY A 567
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.0A)
 0.94A 4mxoA-5a46A:
30.7		 4mxoA-5a46A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.82A 4mxxB-5a46A:
30.6		 4mxxB-5a46A:
32.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
ALA A 640
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
38O  A1769 (-4.0A)
 0.80A 4mxyB-5a46A:
25.7		 4mxyB-5a46A:
32.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
ALA A 640
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
38O  A1769 (-4.0A)
 0.80A 4mxzB-5a46A:
25.7		 4mxzB-5a46A:
32.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 11 LEU A 484
GLY A 485
VAL A 492
ALA A 512
LYS A 514
ASN A 628
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
None
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.55A 4o0sA-5a46A:
24.1		 4o0sA-5a46A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		4 / 6 VAL A 492
ALA A 512
LYS A 514
LEU A 630
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-4.6A)
 0.55A 4o0uA-5a46A:
8.0		 4o0uA-5a46A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		5 / 6 LEU A 484
GLY A 485
VAL A 492
ALA A 512
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.6A)
 0.42A 4o0wA-5a46A:
24.1		 4o0wA-5a46A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
GLY A 485
GLY A 490
VAL A 492
ALA A 512
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
None
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.46A 4otiA-5a46A:
20.1		 4otiA-5a46A:
29.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
LYS A 514
TYR A 563
GLY A 567
LEU A 630
ALA A 640
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.1A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
38O  A1769 (-4.0A)
 0.86A 4otwA-5a46A:
28.9		 4otwA-5a46A:
30.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 ALA A 512
GLU A 531
TYR A 563
LEU A 630
ALA A 640
ASP A 641
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
38O  A1769 (-4.0A)
 0.73A 4qmnA-5a46A:
25.2		 4qmnA-5a46A:
29.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 ALA A 512
GLU A 531
MET A 535
VAL A 561
LEU A 614
CYH A 619
ARG A 622
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.3A)
None
None
None
EDO  A1766 ( 4.4A)
 0.76A 4qrcA-5a46A:
40.3		 4qrcA-5a46A:
64.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
CYH A 619
LEU A 630
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
 0.44A 4r7iA-5a46A:
34.7		 4r7iA-5a46A:
40.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		5 / 12 VAL A 492
ALA A 512
LYS A 514
PHE A 642
GLY A 643
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-3.7A)
EDO  A1766 (-3.6A)
 0.65A 4rzvB-5a46A:
26.8		 4rzvB-5a46A:
28.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLY A 567
ASN A 628
ALA A 640
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-3.4A)
None
EDO  A1766 ( 4.4A)
38O  A1769 (-4.0A)
 0.70A 4twpA-5a46A:
30.7		 4twpA-5a46A:
40.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLY A 567
ASN A 628
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-3.4A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.59A 4twpA-5a46A:
30.7		 4twpA-5a46A:
40.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLY A 567
ASN A 628
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-3.4A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.65A 4twpB-5a46A:
30.7		 4twpB-5a46A:
40.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		10 / 12 ALA A 512
GLU A 531
MET A 535
ILE A 538
VAL A 561
ALA A 564
CYH A 619
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
None
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.76A 4tyjA-5a46A:
36.2		 4tyjA-5a46A:
64.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 10 LEU A 484
VAL A 492
GLU A 531
ILE A 544
VAL A 559
TYR A 563
ILE A 639
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
EDO  A1766 (-4.1A)
None
None
38O  A1769 (-4.2A)
None
 0.57A 4u0iA-5a46A:
33.8		 4u0iA-5a46A:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 10 LEU A 484
VAL A 492
GLU A 531
VAL A 559
TYR A 563
ARG A 622
ILE A 639
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
EDO  A1766 (-4.1A)
None
38O  A1769 (-4.2A)
None
None
 0.94A 4u0iA-5a46A:
33.8		 4u0iA-5a46A:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 ALA A 512
LYS A 514
GLY A 567
CYH A 619
HIS A 621
LEU A 630
 38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-3.4A)
None
None
38O  A1769 (-4.6A)
 0.54A 4u0iA-5a46A:
33.8		 4u0iA-5a46A:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 11 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
ASN A 628
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.49A 4u5jA-5a46A:
31.2		 4u5jA-5a46A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 9 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.58A 4u5jB-5a46A:
31.1		 4u5jB-5a46A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 LEU A 484
ALA A 512
GLU A 531
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.54A 4uxqA-5a46A:
38.5		 4uxqA-5a46A:
64.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
ALA A 512
VAL A 561
LEU A 614
CYH A 619
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 (-4.3A)
None
None
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.55A 4uxqA-5a46A:
38.5		 4uxqA-5a46A:
64.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 7 VAL A 492
MET A 535
ILE A 545
ALA A 564
ARG A 622
ILE A 639
 38O  A1769 (-4.5A)
EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-3.9A)
None
None
 0.70A 4uxqA-5a46A:
38.5		 4uxqA-5a46A:
64.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		10 / 12 ALA A 512
GLU A 531
MET A 534
MET A 535
ILE A 538
VAL A 561
ALA A 564
LEU A 614
HIS A 621
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
None
None
EDO  A1766 ( 4.4A)
 0.52A 4v01A-5a46A:
42.1		 4v01A-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 9 LEU A 484
VAL A 492
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
None
38O  A1769 (-4.6A)
None
 0.50A 4v01A-5a46A:
42.1		 4v01A-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 9 LEU A 484
VAL A 492
ILE A 545
TYR A 563
CYH A 619
ARG A 622
ILE A 639
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
None
None
None
 0.88A 4v01A-5a46A:
42.1		 4v01A-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		10 / 12 ALA A 512
GLU A 531
MET A 534
MET A 535
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
EDO  A1766 (-3.5A)
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
None
None
None
EDO  A1766 ( 4.4A)
 0.48A 4v01B-5a46A:
41.4		 4v01B-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 9 LEU A 484
VAL A 492
LYS A 514
ILE A 538
ILE A 545
TYR A 563
LEU A 630
ILE A 639
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.1A)
None
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
None
 0.54A 4v01B-5a46A:
41.4		 4v01B-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 9 LEU A 484
VAL A 492
LYS A 514
TYR A 563
ARG A 622
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.1A)
38O  A1769 (-4.2A)
None
38O  A1769 (-4.6A)
 0.91A 4v01B-5a46A:
41.4		 4v01B-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		11 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 534
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
GLY A 643
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
None
None
None
EDO  A1766 ( 4.4A)
EDO  A1766 (-3.6A)
 0.23A 4v04A-5a46A:
43.5		 4v04A-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		4 / 8 LYS A 514
MET A 535
TYR A 563
ARG A 622
 38O  A1769 ( 3.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
None
 0.85A 4v04A-5a46A:
43.5		 4v04A-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 8 MET A 535
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
 EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
None
38O  A1769 (-4.6A)
None
 0.23A 4v04A-5a46A:
43.5		 4v04A-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 10 LEU A 484
VAL A 492
ILE A 545
TYR A 563
LEU A 630
ILE A 544
LEU A 644
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
None
None
 1.41A 4v04B-5a46A:
43.3		 4v04B-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 10 LEU A 484
VAL A 492
LYS A 514
MET A 535
TYR A 563
ARG A 622
ILE A 639
LEU A 644
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
None
None
None
 0.66A 4v04B-5a46A:
43.3		 4v04B-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 10 LEU A 484
VAL A 492
LYS A 514
TYR A 563
ILE A 544
LEU A 644
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.1A)
38O  A1769 (-4.2A)
None
None
 1.17A 4v04B-5a46A:
43.3		 4v04B-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		9 / 10 LEU A 484
VAL A 492
MET A 535
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
LEU A 644
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
None
38O  A1769 (-4.6A)
None
None
 0.32A 4v04B-5a46A:
43.3		 4v04B-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		10 / 12 ALA A 512
GLU A 531
MET A 534
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
GLY A 643
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
None
None
None
EDO  A1766 ( 4.4A)
EDO  A1766 (-3.6A)
 0.27A 4v04B-5a46A:
43.3		 4v04B-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
MET A 535
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.74A 4xeyB-5a46A:
30.7		 4xeyB-5a46A:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 LEU A 484
ALA A 512
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.59A 4xliA-5a46A:
31.4		 4xliA-5a46A:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		9 / 12 LEU A 484
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.75A 4xliB-5a46A:
30.9		 4xliB-5a46A:
38.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 LEU A 484
ALA A 512
GLY A 567
LEU A 630
ALA A 640
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
38O  A1769 (-4.0A)
 0.82A 5ajqA-5a46A:
22.0		 5ajqA-5a46A:
27.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		11 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
ILE A 545
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.80A 5bvwA-5a46A:
31.2		 5bvwA-5a46A:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		5 / 12 LEU A 484
ALA A 512
GLY A 567
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.63A 5h2uC-5a46A:
29.1		 5h2uC-5a46A:
35.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
ILE A 545
TYR A 563
ALA A 564
PHE A 642
GLY A 643
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
EDO  A1766 (-3.7A)
EDO  A1766 (-3.6A)
 0.85A 5hesA-5a46A:
2.4		 5hesA-5a46A:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
LYS A 514
TYR A 563
ALA A 564
PHE A 642
GLY A 643
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
EDO  A1766 (-3.7A)
EDO  A1766 (-3.6A)
 0.66A 5hesB-5a46A:
25.9		 5hesB-5a46A:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 ALA A 512
GLU A 531
ILE A 545
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.69A 5i9xA-5a46A:
32.8		 5i9xA-5a46A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 ALA A 512
LYS A 514
GLU A 531
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.77A 5i9yA-5a46A:
32.8		 5i9yA-5a46A:
31.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 11 LEU A 484
GLY A 485
VAL A 492
ALA A 512
TYR A 563
ALA A 564
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
38O  A1769 (-4.6A)
 0.43A 5lvnA-5a46A:
23.3		 5lvnA-5a46A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 GLY A 485
VAL A 492
ALA A 512
LYS A 514
GLU A 531
TYR A 563
GLY A 567
 38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
 0.51A 5mafA-5a46A:
23.8		 5mafA-5a46A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		5 / 12 ALA A 512
MET A 535
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.47A 5mo4A-5a46A:
26.4		 5mo4A-5a46A:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 LEU A 494
ALA A 512
GLU A 531
MET A 535
GLY A 567
LEU A 630
 None
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.55A 5te0A-5a46A:
22.5		 5te0A-5a46A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		3 / 3 GLU A 571
TYR A 572
ARG A 576
 38O  A1769 ( 3.7A)
None
None
 0.54A 5uunA-5a46A:
undetectable		 5uunA-5a46A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		3 / 3 GLU A 571
TYR A 572
ARG A 576
 38O  A1769 ( 3.7A)
None
None
 0.45A 5uunB-5a46A:
undetectable		 5uunB-5a46A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		5 / 12 LEU A 484
GLY A 485
VAL A 492
ALA A 512
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 ( 4.4A)
 0.47A 5xv7A-5a46A:
21.1		 5xv7A-5a46A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
GLY A 567
GLU A 571
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 (-3.4A)
38O  A1769 ( 3.7A)
38O  A1769 (-4.6A)
 0.99A 5y7zA-5a46A:
22.2		 5y7zA-5a46A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
GLY A 567
GLU A 571
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 (-3.4A)
38O  A1769 ( 3.7A)
38O  A1769 (-4.6A)
 0.99A 5y7zA-5a46A:
22.2		 5y7zA-5a46A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		5 / 9 LEU A 484
VAL A 492
LYS A 514
ILE A 545
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.1A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.0A)
 1.01A 5yf9X-5a46A:
19.7		 5yf9X-5a46A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
GLY A 485
VAL A 492
ALA A 512
LYS A 514
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.95A 5yu9A-5a46A:
25.5		 5yu9A-5a46A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 VAL A 492
ALA A 512
GLY A 567
LEU A 630
ASP A 641
LEU A 644
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
None
 0.81A 5yu9D-5a46A:
28.7		 5yu9D-5a46A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		6 / 12 VAL A 492
ALA A 512
LYS A 514
LEU A 630
ASP A 641
LEU A 644
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
None
 1.11A 5yu9D-5a46A:
28.7		 5yu9D-5a46A:
12.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		9 / 12 LEU A 484
GLY A 485
ALA A 512
GLU A 531
MET A 535
VAL A 561
TYR A 563
ALA A 564
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
EDO  A1766 ( 4.4A)
 0.99A 5zv2A-5a46A:
42.0		 5zv2A-5a46A:
78.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		10 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
VAL A 561
TYR A 563
ALA A 564
GLY A 567
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
38O  A1769 (-3.4A)
EDO  A1766 ( 4.4A)
 0.42A 5zv2A-5a46A:
42.0		 5zv2A-5a46A:
78.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
GLY A 485
ALA A 512
MET A 535
VAL A 561
ALA A 564
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-3.6A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
EDO  A1766 ( 4.4A)
 1.07A 5zv2B-5a46A:
40.7		 5zv2B-5a46A:
78.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		10 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
VAL A 561
ALA A 564
GLY A 567
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
38O  A1769 (-3.4A)
EDO  A1766 ( 4.4A)
 0.52A 5zv2B-5a46A:
40.7		 5zv2B-5a46A:
78.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		3 / 3 TYR A 563
LEU A 630
ASP A 641
 38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.46A 5zv2B-5a46A:
16.3		 5zv2B-5a46A:
78.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 545
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.82A 6bsdA-5a46A:
31.0		 6bsdA-5a46A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
ILE A 545
TYR A 563
GLY A 567
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
 0.87A 6bsdA-5a46A:
31.0		 6bsdA-5a46A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.72A 6hd4A-5a46A:
30.4		 6hd4A-5a46A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.74A 6hd4B-5a46A:
30.2		 6hd4B-5a46A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
 0.81A 6hd6B-5a46A:
29.9		 6hd6B-5a46A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
ILE A 538
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
 0.88A 6hd6B-5a46A:
29.9		 6hd6B-5a46A:
12.63