SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '38I'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.29A 1v8bA-4ixuA:
2.1		 1v8bA-4ixuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.30A 1v8bB-4ixuA:
2.0		 1v8bB-4ixuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.28A 1v8bD-4ixuA:
undetectable		 1v8bD-4ixuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.95A 2v2gA-4ixuA:
undetectable
2v2gB-4ixuA:
undetectable		 2v2gA-4ixuA:
20.87
2v2gB-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.98A 2v2gA-4ixuA:
undetectable
2v2gB-4ixuA:
undetectable		 2v2gA-4ixuA:
20.87
2v2gB-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.99A 2v2gC-4ixuA:
undetectable
2v2gD-4ixuA:
undetectable		 2v2gC-4ixuA:
20.87
2v2gD-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.99A 2v2gC-4ixuA:
undetectable
2v2gD-4ixuA:
undetectable		 2v2gC-4ixuA:
20.87
2v2gD-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.99A 2v32A-4ixuA:
undetectable
2v32B-4ixuA:
undetectable		 2v32A-4ixuA:
20.87
2v32B-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.99A 2v32A-4ixuA:
undetectable
2v32B-4ixuA:
undetectable		 2v32A-4ixuA:
20.87
2v32B-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.95A 2v32C-4ixuA:
undetectable
2v32D-4ixuA:
undetectable		 2v32C-4ixuA:
20.87
2v32D-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 163
VAL A 164
SER A 165
GLU A 205
 None
None
None
38I  A 406 ( 4.0A)
 0.99A 2v41E-4ixuA:
undetectable
2v41F-4ixuA:
undetectable		 2v41E-4ixuA:
20.87
2v41F-4ixuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.28A 3ce6D-4ixuA:
undetectable		 3ce6D-4ixuA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.28A 3g1uB-4ixuA:
2.0		 3g1uB-4ixuA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.33A 3g1uD-4ixuA:
undetectable		 3g1uD-4ixuA:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_A_DMOA551_1
(ARGINASE-1)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 HIS A 145
ASN A 149
SER A 155
ASP A 202
GLU A 205
 MN  A 402 ( 3.3A)
38I  A 406 (-4.2A)
38I  A 406 ( 3.7A)
38I  A 406 (-3.1A)
38I  A 406 ( 4.0A)
 1.25A 3gn0A-4ixuA:
54.6		 3gn0A-4ixuA:
60.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_A_DMOA551_1
(ARGINASE-1)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		9 / 9 HIS A 145
ASP A 147
ASN A 149
SER A 156
HIS A 160
GLY A 161
ASP A 202
GLU A 205
THR A 265
 MN  A 402 ( 3.3A)
38I  A 406 ( 2.5A)
38I  A 406 (-4.2A)
38I  A 406 (-2.7A)
38I  A 406 (-3.5A)
38I  A 406 ( 3.7A)
38I  A 406 (-3.1A)
38I  A 406 ( 4.0A)
38I  A 406 (-3.7A)
 0.27A 3gn0A-4ixuA:
54.6		 3gn0A-4ixuA:
60.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_B_DMOB552_1
(ARGINASE-1)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 HIS A 145
ASN A 149
SER A 155
ASP A 202
GLU A 205
 MN  A 402 ( 3.3A)
38I  A 406 (-4.2A)
38I  A 406 ( 3.7A)
38I  A 406 (-3.1A)
38I  A 406 ( 4.0A)
 1.21A 3gn0B-4ixuA:
54.7		 3gn0B-4ixuA:
60.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_B_DMOB552_1
(ARGINASE-1)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		9 / 9 HIS A 145
ASP A 147
ASN A 149
SER A 156
HIS A 160
GLY A 161
ASP A 202
GLU A 205
THR A 265
 MN  A 402 ( 3.3A)
38I  A 406 ( 2.5A)
38I  A 406 (-4.2A)
38I  A 406 (-2.7A)
38I  A 406 (-3.5A)
38I  A 406 ( 3.7A)
38I  A 406 (-3.1A)
38I  A 406 ( 4.0A)
38I  A 406 (-3.7A)
 0.26A 3gn0B-4ixuA:
54.7		 3gn0B-4ixuA:
60.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.29A 3n58C-4ixuA:
2.4		 3n58C-4ixuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.30A 3ondA-4ixuA:
undetectable		 3ondA-4ixuA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.30A 3ondB-4ixuA:
2.5		 3ondB-4ixuA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_O_CLMO221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 HIS A 160
THR A 154
PHE A 166
SER A 156
VAL A  87
 38I  A 406 (-3.5A)
None
None
38I  A 406 (-2.7A)
None
 1.35A 3u9fM-4ixuA:
undetectable
3u9fO-4ixuA:
undetectable		 3u9fM-4ixuA:
22.92
3u9fO-4ixuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ASP A 202
ASP A 251
ASP A 147
GLU A 205
 38I  A 406 (-3.1A)
MN  A 402 (-2.8A)
38I  A 406 ( 2.5A)
38I  A 406 ( 4.0A)
 1.29A 4gkhJ-4ixuA:
undetectable		 4gkhJ-4ixuA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 143
ASP A 147
ASN A 158
 MN  A 401 (-2.5A)
38I  A 406 ( 2.5A)
None
 0.82A 4q5mA-4ixuA:
undetectable		 4q5mA-4ixuA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.30A 5axdA-4ixuA:
2.2		 5axdA-4ixuA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.30A 5axdC-4ixuA:
2.1		 5axdC-4ixuA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 VAL A 295
GLU A 296
GLY A 118
LEU A 122
 None
38I  A 406 (-3.8A)
None
None
 1.34A 5g5gC-4ixuA:
undetectable		 5g5gC-4ixuA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.26A 5m5kB-4ixuA:
undetectable		 5m5kB-4ixuA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.31A 5m66A-4ixuA:
undetectable		 5m66A-4ixuA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.29A 5m66C-4ixuA:
3.1		 5m66C-4ixuA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.29A 5utuF-4ixuA:
undetectable		 5utuF-4ixuA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
 1.26A 6f3nB-4ixuA:
2.6		 6f3nB-4ixuA:
20.55