SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '37B'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.68A 1j36A-4qmeA:
6.6		 1j36A-4qmeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.68A 1j36B-4qmeA:
6.6		 1j36B-4qmeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.66A 1j37A-4qmeA:
7.4		 1j37A-4qmeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.67A 1j37B-4qmeA:
3.9		 1j37B-4qmeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.66A 1o86A-4qmeA:
7.5		 1o86A-4qmeA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		6 / 12 ALA A 258
HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 (-3.8A)
37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.63A 2c6nA-4qmeA:
4.3		 2c6nA-4qmeA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.69A 2c6nB-4qmeA:
undetectable		 2c6nB-4qmeA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.59A 2x8zA-4qmeA:
8.4		 2x8zA-4qmeA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.62A 2x91A-4qmeA:
4.8		 2x91A-4qmeA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 7 GLU A 316
HIS A 293
HIS A 297
GLU A 294
 ZN  A 908 ( 2.0A)
37B  A 901 ( 3.2A)
ZN  A 908 ( 3.2A)
37B  A 901 (-2.6A)
 0.85A 3a6jB-4qmeA:
undetectable		 3a6jB-4qmeA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 8 GLU A 316
HIS A 293
HIS A 297
GLU A 294
 ZN  A 908 ( 2.0A)
37B  A 901 ( 3.2A)
ZN  A 908 ( 3.2A)
37B  A 901 (-2.6A)
 0.85A 3a6jC-4qmeA:
undetectable		 3a6jC-4qmeA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 8 GLU A 316
HIS A 293
HIS A 297
GLU A 294
 ZN  A 908 ( 2.0A)
37B  A 901 ( 3.2A)
ZN  A 908 ( 3.2A)
37B  A 901 (-2.6A)
 0.85A 3a6jF-4qmeA:
undetectable		 3a6jF-4qmeA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 11 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.67A 4c2pA-4qmeA:
7.5		 4c2pA-4qmeA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 9 GLY A 257
HIS A 293
GLU A 294
GLU A 316
TYR A 377
 37B  A 901 (-3.4A)
37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.35A 4dprA-4qmeA:
23.2		 4dprA-4qmeA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		5 / 12 HIS A 293
GLU A 294
HIS A 297
GLU A 316
TYR A 372
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
ZN  A 908 ( 2.0A)
37B  A 901 (-3.5A)
 1.26A 4r7lA-4qmeA:
22.4		 4r7lA-4qmeA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		6 / 12 HIS A 293
GLU A 294
HIS A 297
TRP A 309
GLU A 316
TYR A 377
 37B  A 901 ( 3.2A)
37B  A 901 (-2.6A)
ZN  A 908 ( 3.2A)
None
ZN  A 908 ( 2.0A)
GOL  A 910 ( 2.6A)
 0.35A 4r7lA-4qmeA:
22.4		 4r7lA-4qmeA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 5 TYR A 181
PRO A 118
GLU A 316
TYR A 372
 None
37B  A 901 ( 4.7A)
ZN  A 908 ( 2.0A)
37B  A 901 (-3.5A)
 1.35A 4w5tA-4qmeA:
3.3		 4w5tA-4qmeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 6 TYR A 181
PRO A 118
GLU A 316
TYR A 372
 None
37B  A 901 ( 4.7A)
ZN  A 908 ( 2.0A)
37B  A 901 (-3.5A)
 1.33A 4z4cA-4qmeA:
3.4		 4z4cA-4qmeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 5 GLU A 260
ALA A 258
GLU A 294
GLU A 316
 37B  A 901 (-2.2A)
37B  A 901 (-3.8A)
37B  A 901 (-2.6A)
ZN  A 908 ( 2.0A)
 1.44A 5dwkC-4qmeA:
undetectable		 5dwkC-4qmeA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 6 GLU A 117
PHE A 371
THR A 373
TYR A 372
 37B  A 901 (-2.5A)
None
None
37B  A 901 (-3.5A)
 1.18A 5lrbA-4qmeA:
undetectable		 5lrbA-4qmeA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4qme AMINOPEPTIDASE N
(Neisseria
meningitidis) 		4 / 4 HIS A 297
HIS A 293
TYR A 377
GLU A 316
 ZN  A 908 ( 3.2A)
37B  A 901 ( 3.2A)
GOL  A 910 ( 2.6A)
ZN  A 908 ( 2.0A)
 1.41A 5pahA-4qmeA:
undetectable		 5pahA-4qmeA:
16.55