SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '35H'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 GLY A 411
HIS A 449
ALA A 468
ASP A 469
PHE A 470
 None
35H  A 701 ( 4.4A)
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.69A 3cs9B-4tptA:
22.6		 3cs9B-4tptA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 HIS A 449
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.4A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.46A 3ik3A-4tptA:
22.0		 3ik3A-4tptA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 HIS A 449
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.4A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.44A 3ik3B-4tptA:
21.8		 3ik3B-4tptA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		8 / 12 THR A 405
LEU A 442
HIS A 449
ARG A 450
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 (-3.8A)
35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
None
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 1.10A 3zosA-4tptA:
20.5		 3zosA-4tptA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		8 / 12 THR A 405
LEU A 442
HIS A 449
ARG A 450
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 (-3.8A)
35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
None
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 1.11A 3zosB-4tptA:
20.4		 3zosB-4tptA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A 389
THR A 405
HIS A 449
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 (-4.6A)
35H  A 701 (-3.8A)
35H  A 701 ( 4.4A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 1.02A 4c8bA-4tptA:
21.3		 4c8bA-4tptA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 442
ARG A 450
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.7A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.83A 4qrcA-4tptA:
21.7		 4qrcA-4tptA:
29.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 HIS A 449
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.4A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.46A 4tyjA-4tptA:
21.9		 4tyjA-4tptA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A 442
HIS A 449
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.48A 4uxqA-4tptA:
21.7		 4uxqA-4tptA:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 442
HIS A 449
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.46A 4v01A-4tptA:
21.4		 4v01A-4tptA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 442
HIS A 449
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.53A 4v01B-4tptA:
21.6		 4v01B-4tptA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 442
HIS A 449
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.52A 4v04B-4tptA:
21.2		 4v04B-4tptA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		3 / 3 LEU A 403
LEU A 472
ARG A 364
 35H  A 701 ( 4.2A)
35H  A 701 (-3.7A)
None
 0.58A 6fgcA-4tptA:
undetectable		 6fgcA-4tptA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		3 / 3 LEU A 403
LEU A 472
ARG A 364
 35H  A 701 ( 4.2A)
35H  A 701 (-3.7A)
None
 0.62A 6fgdA-4tptA:
undetectable		 6fgdA-4tptA:
20.57