SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '30U'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IA4_B_MTXB164_1 (DIHYDROFOLATE REDUCTASE)	4qdv	M7GPPPX DIPHOSPHATASE (Homo sapiens)	5 / 12	ILE A 219 GLU A 185 SER A 172 ILE A 173 ARG A 225	30U A 401 (-4.4A) 30U A 401 (-2.3A) None None None	1.31A	3ia4B-4qdvA: undetectable	3ia4B-4qdvA: 16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U52_A_CUA515_0 (PHENOL HYDROXYLASE COMPONENT PHL PHENOL HYDROXYLASE COMPONENT PHN)	4qdv	M7GPPPX DIPHOSPHATASE (Homo sapiens)	3 / 3	HIS A 277 HIS A 279 ILE A 219	PO4 A 402 (-3.7A) PO4 A 402 (-4.0A) 30U A 401 (-4.4A)	0.85A	3u52A-4qdvA: undetectable 3u52C-4qdvA: undetectable	3u52A-4qdvA: 23.05 3u52C-4qdvA: 23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KM9_B_ADNB201_1 (HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 2, MITOCHONDRIAL)	4qdv	M7GPPPX DIPHOSPHATASE (Homo sapiens)	5 / 12	ILE A 179 ASP A 205 SER A 272 HIS A 277 HIS A 279	None 30U A 401 (-2.4A) PO4 A 404 ( 2.7A) PO4 A 402 (-3.7A) PO4 A 402 (-4.0A)	0.76A	5km9B-4qdvA: 11.4	5km9B-4qdvA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UVM_B_ADNB207_1 (HISTIDINE TRIAD (HIT) PROTEIN)	4qdv	M7GPPPX DIPHOSPHATASE (Homo sapiens)	6 / 12	VAL A 176 ILE A 179 ILE A 203 ASP A 205 HIS A 277 HIS A 279	None None 30U A 401 ( 4.0A) 30U A 401 (-2.4A) PO4 A 402 (-3.7A) PO4 A 402 (-4.0A)	1.26A	5uvmB-4qdvA: 10.6	5uvmB-4qdvA: 18.51

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3IA4_B_MTXB164_1","DIHYDROFOLATE REDUCTASE","4qdv","M7GPPPX DIPHOSPHATASE","Homo sapiens",5,"ILE A 219;GLU A 185;SER A 172;ILE A 173;ARG A 225","30U A 401 (-4.4A);30U A 401 (-2.3A);None;None;None","1.31A","3ia4B-4qdvA:undetectable",null],["3U52_A_CUA515_0","PHENOL HYDROXYLASE COMPONENT PHL;PHENOL HYDROXYLASE COMPONENT PHN","4qdv","M7GPPPX DIPHOSPHATASE","Homo sapiens",3,"HIS A 277;HIS A 279;ILE A 219","PO4 A 402 (-3.7A);PO4 A 402 (-4.0A);30U A 401 (-4.4A)","0.85A","3u52A-4qdvA:undetectable;3u52C-4qdvA:undetectable","3ia4B-4qdvA:16.52"],["5KM9_B_ADNB201_1","HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 2, MITOCHONDRIAL","4qdv","M7GPPPX DIPHOSPHATASE","Homo sapiens",5,"ILE A 179;ASP A 205;SER A 272;HIS A 277;HIS A 279","None;30U A 401 (-2.4A);PO4 A 404 ( 2.7A);PO4 A 402 (-3.7A);PO4 A 402 (-4.0A)","0.76A","5km9B-4qdvA:11.4","3u52A-4qdvA:23.05;3u52C-4qdvA:23.12"],["5UVM_B_ADNB207_1","HISTIDINE TRIAD (HIT) PROTEIN","4qdv","M7GPPPX DIPHOSPHATASE","Homo sapiens",6,"VAL A 176;ILE A 179;ILE A 203;ASP A 205;HIS A 277;HIS A 279","None;None;30U A 401 ( 4.0A);30U A 401 (-2.4A);PO4 A 402 (-3.7A);PO4 A 402 (-4.0A)","1.26A","5uvmB-4qdvA:10.6","5km9B-4qdvA:18.75"]]