SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '30R'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 9 PHE A 688
ILE A 666
GLY A 683
PHE A 684
TYR A 728
 None
None
30R  A 801 ( 4.2A)
None
30R  A 801 (-3.4A)
 1.49A 1i00B-4pkvA:
undetectable		 1i00B-4pkvA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 12 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.69A 1j36A-4pkvA:
undetectable		 1j36A-4pkvA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 12 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.70A 1j36B-4pkvA:
undetectable		 1j36B-4pkvA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 11 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.67A 1j37A-4pkvA:
5.1		 1j37A-4pkvA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 11 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.67A 1j37B-4pkvA:
undetectable		 1j37B-4pkvA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		4 / 7 SER A 746
ASP A 748
GLU A 682
GLU A 739
 None
None
None
30R  A 801 (-3.4A)
 1.17A 1knyA-4pkvA:
undetectable
1knyB-4pkvA:
undetectable		 1knyA-4pkvA:
19.09
1knyB-4pkvA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		4 / 8 GLU A 739
SER A 746
ASP A 748
GLU A 682
 30R  A 801 (-3.4A)
None
None
None
 1.17A 1knyA-4pkvA:
undetectable
1knyB-4pkvA:
undetectable		 1knyA-4pkvA:
19.09
1knyB-4pkvA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 12 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.64A 1o86A-4pkvA:
5.0		 1o86A-4pkvA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 12 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.59A 2c6nA-4pkvA:
3.3		 2c6nA-4pkvA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 12 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.63A 2c6nB-4pkvA:
undetectable		 2c6nB-4pkvA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 10 PHE A 688
ILE A 666
GLY A 683
PHE A 684
TYR A 728
 None
None
30R  A 801 ( 4.2A)
None
30R  A 801 (-3.4A)
 1.36A 2tsrC-4pkvA:
undetectable		 2tsrC-4pkvA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 9 PHE A 688
ILE A 666
GLY A 683
PHE A 684
TYR A 728
 None
None
30R  A 801 ( 4.2A)
None
30R  A 801 (-3.4A)
 1.43A 2tsrD-4pkvA:
undetectable		 2tsrD-4pkvA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 11 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.63A 2x8zA-4pkvA:
4.9		 2x8zA-4pkvA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 12 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.63A 2x91A-4pkvA:
undetectable		 2x91A-4pkvA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 11 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.67A 4c2pA-4pkvA:
4.7		 4c2pA-4pkvA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 10 PHE A 688
ILE A 666
GLY A 683
PHE A 684
TYR A 728
 None
None
30R  A 801 ( 4.2A)
None
30R  A 801 (-3.4A)
 1.43A 4eb4D-4pkvA:
undetectable		 4eb4D-4pkvA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 12 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.40A 4r7lA-4pkvA:
2.8		 4r7lA-4pkvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		4 / 4 HIS A 690
HIS A 686
TYR A 728
GLU A 735
 ZN  A 802 ( 3.4A)
ZN  A 802 ( 3.6A)
30R  A 801 (-3.4A)
ZN  A 802 ( 2.5A)
 1.41A 5pahA-4pkvA:
undetectable		 5pahA-4pkvA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 10 PHE A 688
ILE A 666
GLY A 683
PHE A 684
TYR A 728
 None
None
30R  A 801 ( 4.2A)
None
30R  A 801 (-3.4A)
 1.44A 5x66D-4pkvA:
undetectable		 5x66D-4pkvA:
18.86