SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '30K'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 ALA A 121
LYS A 123
GLU A 140
THR A 169
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.74A 1m17A-4aw5A:
28.1		 1m17A-4aw5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
GLU A 140
MET A 144
THR A 169
PHE A 171
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
 0.81A 1opjB-4aw5A:
26.5		 1opjB-4aw5A:
39.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		4 / 8 THR A 169
GLY A 157
ILE A 167
VAL A 158
 30K  A1365 (-3.8A)
None
None
None
 0.94A 1rxcK-4aw5A:
undetectable		 1rxcK-4aw5A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		4 / 7 ASN A 221
HIS A 214
PHE A 235
ILE A 200
 30K  A1365 (-4.4A)
None
None
None
 1.25A 1tdnA-4aw5A:
undetectable		 1tdnA-4aw5A:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
GLU A 140
THR A 169
LEU A 207
HIS A 214
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
None
None
 0.87A 1uwjA-4aw5A:
28.4		 1uwjA-4aw5A:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 ILE A  97
VAL A 105
ALA A 121
GLU A 140
THR A 169
LEU A 207
 30K  A1365 (-4.5A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
None
 1.01A 1uwjB-4aw5A:
7.7		 1uwjB-4aw5A:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
GLU A 140
THR A 169
LEU A 207
HIS A 214
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
None
None
 0.87A 1uwjB-4aw5A:
7.7		 1uwjB-4aw5A:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 ALA A 121
GLU A 140
MET A 144
ILE A 167
THR A 169
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 (-3.2A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.52A 2gqgA-4aw5A:
29.4		 2gqgA-4aw5A:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.56A 2gqgA-4aw5A:
29.4		 2gqgA-4aw5A:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 105
ALA A 121
GLU A 140
MET A 144
ILE A 167
THR A 169
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.73A 2gqgB-4aw5A:
33.0		 2gqgB-4aw5A:
40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 105
ALA A 121
MET A 144
THR A 169
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 1.01A 2hyyB-4aw5A:
26.9		 2hyyB-4aw5A:
39.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
THR A 169
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.51A 2hyyC-4aw5A:
27.1		 2hyyC-4aw5A:
39.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
GLU A 140
MET A 144
ILE A 167
PHE A 171
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
None
30K  A1365 (-4.4A)
 0.76A 2hyyD-4aw5A:
26.9		 2hyyD-4aw5A:
39.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 ALA A 121
LYS A 123
MET A 144
THR A 169
GLY A 175
LEU A 223
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.72A 2itoA-4aw5A:
32.7		 2itoA-4aw5A:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		9 / 12 GLY A  98
VAL A 105
ALA A 121
LYS A 123
GLU A 140
MET A 144
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.82A 2ityA-4aw5A:
29.2		 2ityA-4aw5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		9 / 12 GLY A  98
VAL A 105
ALA A 121
LYS A 123
MET A 144
THR A 169
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.67A 2ityA-4aw5A:
29.2		 2ityA-4aw5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 105
ALA A 121
LYS A 123
GLU A 140
MET A 144
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.72A 2itzA-4aw5A:
29.1		 2itzA-4aw5A:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 105
ALA A 121
LYS A 123
MET A 144
THR A 169
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.70A 2itzA-4aw5A:
29.1		 2itzA-4aw5A:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 GLY A  98
VAL A 105
ALA A 121
MET A 172
GLY A 175
ASP A 234
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.5A)
30K  A1365 (-3.3A)
 0.62A 2wgjA-4aw5A:
31.7		 2wgjA-4aw5A:
35.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 9 VAL A 105
ALA A 121
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.37A 2xp2A-4aw5A:
14.1		 2xp2A-4aw5A:
33.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		10 / 12 ILE A  97
ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
THR A 169
GLY A 175
LEU A 223
SER A 233
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
 0.77A 2y6oA-4aw5A:
32.4		 2y6oA-4aw5A:
76.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 ILE A  97
VAL A 105
ALA A 121
ILE A 153
MET A 172
GLY A 175
LEU A 223
 30K  A1365 (-4.5A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.58A 2y7jA-4aw5A:
20.4		 2y7jA-4aw5A:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 105
ALA A 121
ILE A 153
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.65A 2y7jA-4aw5A:
20.4		 2y7jA-4aw5A:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 10 ILE A  97
VAL A 105
ALA A 121
ILE A 153
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 (-4.5A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.63A 2y7jB-4aw5A:
20.2		 2y7jB-4aw5A:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 10 ILE A  97
VAL A 105
ALA A 121
ILE A 153
MET A 172
GLY A 175
LEU A 223
 30K  A1365 (-4.5A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.54A 2y7jC-4aw5A:
20.6		 2y7jC-4aw5A:
27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 10 ILE A  97
VAL A 105
ALA A 121
ILE A 153
MET A 172
GLY A 175
LEU A 223
 30K  A1365 (-4.5A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.45A 2y7jD-4aw5A:
25.1		 2y7jD-4aw5A:
27.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		9 / 12 ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
THR A 169
MET A 172
GLY A 175
LEU A 223
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.51A 2zvaA-4aw5A:
34.0		 2zvaA-4aw5A:
39.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 GLY A  98
ALA A 121
LYS A 123
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 ( 3.9A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.58A 3c7qA-4aw5A:
27.5		 3c7qA-4aw5A:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		5 / 10 VAL A 105
LYS A 123
ILE A 167
PHE A 171
VAL A 232
 30K  A1365 ( 4.6A)
30K  A1365 (-3.8A)
None
30K  A1365 (-4.4A)
None
 0.63A 3cs9A-4aw5A:
27.1		 3cs9A-4aw5A:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 ALA A 121
GLU A 140
MET A 144
THR A 169
PHE A 171
HIS A 214
 30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
 1.08A 3cs9C-4aw5A:
27.5		 3cs9C-4aw5A:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 ALA A 121
GLU A 140
MET A 144
THR A 169
PHE A 171
HIS A 214
 30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
 0.98A 3cs9D-4aw5A:
27.2		 3cs9D-4aw5A:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		5 / 12 ALA A 121
THR A 169
PHE A 171
GLY A 175
HIS A 214
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
None
 0.62A 3cs9D-4aw5A:
27.2		 3cs9D-4aw5A:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 105
ALA A 121
GLU A 140
MET A 144
ILE A 167
THR A 169
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.73A 3g5dA-4aw5A:
28.1		 3g5dA-4aw5A:
42.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 105
ALA A 121
LYS A 123
GLU A 140
MET A 144
THR A 169
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.74A 3g5dB-4aw5A:
28.1		 3g5dB-4aw5A:
42.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		9 / 12 ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
THR A 169
GLY A 175
LEU A 223
SER A 233
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
 0.67A 3k54A-4aw5A:
33.2		 3k54A-4aw5A:
37.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
GLU A 140
MET A 144
THR A 169
PHE A 171
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
 0.77A 3k5vA-4aw5A:
32.1		 3k5vA-4aw5A:
39.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
THR A 169
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.70A 3k5vA-4aw5A:
32.1		 3k5vA-4aw5A:
39.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 105
ALA A 121
MET A 144
THR A 169
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 1.03A 3k5vB-4aw5A:
26.8		 3k5vB-4aw5A:
39.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 11 ILE A  97
ALA A 121
LYS A 123
PHE A 171
MET A 172
GLY A 175
LEU A 223
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.58A 3miyA-4aw5A:
30.6		 3miyA-4aw5A:
39.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 11 ILE A  97
ALA A 121
PHE A 171
MET A 172
GLY A 175
LEU A 223
SER A 233
ASP A 234
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
30K  A1365 (-3.3A)
 0.83A 3miyA-4aw5A:
30.6		 3miyA-4aw5A:
39.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 9 ILE A  97
ALA A 121
LYS A 123
PHE A 171
MET A 172
GLY A 175
LEU A 223
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.50A 3miyB-4aw5A:
34.3		 3miyB-4aw5A:
39.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 9 ILE A  97
ALA A 121
PHE A 171
MET A 172
GLY A 175
LEU A 223
SER A 233
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
 0.66A 3miyB-4aw5A:
34.3		 3miyB-4aw5A:
39.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
GLU A 140
MET A 144
THR A 169
PHE A 171
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
 0.83A 3ms9A-4aw5A:
26.9		 3ms9A-4aw5A:
39.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
THR A 169
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.63A 3ms9B-4aw5A:
27.0		 3ms9B-4aw5A:
39.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
GLU A 140
MET A 144
THR A 169
PHE A 171
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
 0.81A 3mssA-4aw5A:
27.0		 3mssA-4aw5A:
39.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
THR A 169
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.68A 3mssB-4aw5A:
32.0		 3mssB-4aw5A:
39.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
GLU A 140
MET A 144
THR A 169
PHE A 171
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
 0.84A 3mssC-4aw5A:
27.0		 3mssC-4aw5A:
39.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 ILE A  97
VAL A 105
ALA A 121
LYS A 123
THR A 169
PHE A 235
 30K  A1365 (-4.5A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-3.8A)
None
 1.01A 3og7A-4aw5A:
28.2		 3og7A-4aw5A:
32.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 GLY A  98
VAL A 105
ALA A 121
LYS A 123
ILE A 153
THR A 169
LEU A 223
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
 0.99A 3ohtA-4aw5A:
17.5		 3ohtA-4aw5A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 GLY A  98
VAL A 105
ALA A 121
ILE A 153
THR A 169
GLY A 175
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
 0.97A 3ohtB-4aw5A:
17.5		 3ohtB-4aw5A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 GLY A  98
VAL A 105
ALA A 121
ILE A 153
THR A 169
LEU A 223
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
 0.98A 3ohtB-4aw5A:
17.5		 3ohtB-4aw5A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 GLY A  98
VAL A 105
ALA A 121
LYS A 123
ILE A 153
LEU A 223
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-4.5A)
 1.01A 3ohtB-4aw5A:
17.5		 3ohtB-4aw5A:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		5 / 9 ILE A 167
MET A 172
ARG A 215
LEU A 223
VAL A 232
 None
None
None
30K  A1365 (-4.5A)
None
 0.73A 3oxzA-4aw5A:
26.8		 3oxzA-4aw5A:
39.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
GLU A 140
MET A 144
THR A 169
PHE A 171
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
 0.68A 3pyyA-4aw5A:
27.1		 3pyyA-4aw5A:
37.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 105
ALA A 121
LYS A 123
GLU A 140
MET A 144
THR A 169
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.76A 3qlgA-4aw5A:
28.1		 3qlgA-4aw5A:
42.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 105
ALA A 121
GLU A 140
MET A 144
THR A 169
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.88A 3qlgB-4aw5A:
27.7		 3qlgB-4aw5A:
42.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 105
ALA A 121
MET A 144
ILE A 167
THR A 169
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.47A 3sxrA-4aw5A:
32.1		 3sxrA-4aw5A:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 105
ALA A 121
MET A 144
THR A 169
GLY A 175
LEU A 223
SER A 233
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
 0.63A 3sxrB-4aw5A:
31.6		 3sxrB-4aw5A:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 ALA A 121
LYS A 123
ILE A 167
THR A 169
PHE A 171
MET A 172
GLY A 175
LEU A 223
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.46A 3ue4A-4aw5A:
33.5		 3ue4A-4aw5A:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 105
ALA A 121
MET A 144
ILE A 167
THR A 169
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.70A 3ue4B-4aw5A:
27.1		 3ue4B-4aw5A:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		5 / 12 ALA A 121
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 (-3.2A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.38A 3zbfA-4aw5A:
28.9		 3zbfA-4aw5A:
37.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		5 / 11 ALA A 121
LYS A 123
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.54A 4agdA-4aw5A:
26.3		 4agdA-4aw5A:
29.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 9 VAL A 105
ALA A 121
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.33A 4anqA-4aw5A:
20.8		 4anqA-4aw5A:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 9 VAL A 105
ALA A 121
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.35A 4ansA-4aw5A:
33.8		 4ansA-4aw5A:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 105
ALA A 121
ILE A 143
MET A 144
ILE A 153
THR A 169
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
 1.10A 4bkjA-4aw5A:
27.0		 4bkjA-4aw5A:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
GLU A 140
ILE A 143
MET A 144
ILE A 153
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
None
None
 0.91A 4bkjB-4aw5A:
26.9		 4bkjB-4aw5A:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 105
ALA A 121
ILE A 143
MET A 144
ILE A 153
THR A 169
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
 1.12A 4bkjB-4aw5A:
26.9		 4bkjB-4aw5A:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 105
ALA A 121
LYS A 123
THR A 169
MET A 172
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.54A 4hjoA-4aw5A:
30.7		 4hjoA-4aw5A:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 10 ILE A  97
ALA A 121
PHE A 171
GLY A 175
LEU A 223
SER A 233
ASP A 234
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
30K  A1365 (-3.3A)
 0.83A 4ks8A-4aw5A:
24.8		 4ks8A-4aw5A:
32.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 GLY A 100
VAL A 105
ALA A 121
LYS A 123
GLY A 175
SER A 179
LEU A 223
ASP A 234
 30K  A1365 ( 4.4A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
None
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.50A 4mkcA-4aw5A:
27.5		 4mkcA-4aw5A:
32.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		9 / 12 VAL A 105
ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
THR A 169
GLY A 175
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-3.3A)
 0.56A 4mxoA-4aw5A:
27.7		 4mxoA-4aw5A:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		9 / 12 VAL A 105
ALA A 121
LYS A 123
GLU A 140
ILE A 167
THR A 169
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.58A 4mxoB-4aw5A:
27.8		 4mxoB-4aw5A:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
THR A 169
GLY A 175
LEU A 223
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.70A 4mxxA-4aw5A:
27.6		 4mxxA-4aw5A:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 105
ALA A 121
LYS A 123
THR A 169
MET A 172
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.35A 4mxxB-4aw5A:
29.8		 4mxxB-4aw5A:
42.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		4 / 6 VAL A 105
ALA A 121
LYS A 123
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
 0.61A 4o0uA-4aw5A:
18.7		 4o0uA-4aw5A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		5 / 8 ILE A  97
GLY A 100
VAL A 105
ALA A 121
LEU A 223
 30K  A1365 (-4.5A)
30K  A1365 ( 4.4A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-4.5A)
 0.44A 4ogrA-4aw5A:
16.1		 4ogrA-4aw5A:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 11 ILE A  97
ALA A 121
LYS A 123
GLU A 140
ILE A 167
ASP A 234
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.3A)
 0.81A 4qmsA-4aw5A:
26.6		 4qmsA-4aw5A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 11 ILE A  97
ALA A 121
LYS A 123
ILE A 167
LEU A 223
ASP A 234
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.62A 4qmsA-4aw5A:
26.6		 4qmsA-4aw5A:
26.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
LYS A 123
GLU A 140
MET A 144
THR A 169
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.8A)
 0.82A 4r7iA-4aw5A:
26.7		 4r7iA-4aw5A:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		5 / 10 ILE A  97
ALA A 121
LYS A 123
ILE A 153
THR A 169
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
 0.59A 4rz7A-4aw5A:
7.8		 4rz7A-4aw5A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		5 / 10 ILE A  97
ALA A 121
LYS A 123
THR A 169
LEU A 223
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
 0.82A 4rz7A-4aw5A:
7.8		 4rz7A-4aw5A:
15.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		9 / 12 VAL A 105
ALA A 121
LYS A 123
PHE A 171
MET A 172
GLY A 175
ASN A 221
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.4A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.73A 4twpA-4aw5A:
27.1		 4twpA-4aw5A:
39.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		9 / 12 VAL A 105
ALA A 121
LYS A 123
PHE A 171
MET A 172
GLY A 175
ASN A 221
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.4A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.72A 4twpB-4aw5A:
33.3		 4twpB-4aw5A:
39.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 9 VAL A 105
ALA A 121
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.58A 4u5jB-4aw5A:
27.7		 4u5jB-4aw5A:
42.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 11 ALA A 121
THR A 169
MET A 172
GLY A 175
ASN A 221
LEU A 223
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.4A)
30K  A1365 (-4.5A)
 0.32A 4wa9A-4aw5A:
29.1		 4wa9A-4aw5A:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 105
ALA A 121
LYS A 123
THR A 169
PHE A 171
MET A 172
ASN A 221
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
30K  A1365 (-4.4A)
 0.93A 4wa9B-4aw5A:
32.4		 4wa9B-4aw5A:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 105
ALA A 121
THR A 169
PHE A 171
MET A 172
GLY A 175
ASN A 221
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.4A)
30K  A1365 (-4.5A)
 0.67A 4wa9B-4aw5A:
32.4		 4wa9B-4aw5A:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		9 / 12 VAL A 105
ALA A 121
LYS A 123
MET A 144
ILE A 167
THR A 169
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.79A 4xeyA-4aw5A:
32.9		 4xeyA-4aw5A:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 105
ALA A 121
LYS A 123
ILE A 167
THR A 169
PHE A 171
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.46A 4xeyB-4aw5A:
26.7		 4xeyB-4aw5A:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 ALA A 121
GLU A 140
MET A 144
THR A 169
MET A 172
GLY A 175
LEU A 223
 30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.65A 4xliA-4aw5A:
27.1		 4xliA-4aw5A:
38.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
THR A 169
GLY A 175
LEU A 223
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.62A 4xliB-4aw5A:
29.2		 4xliB-4aw5A:
38.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		5 / 12 ALA A 121
LYS A 123
THR A 169
ASP A 234
PHE A 235
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-3.8A)
30K  A1365 (-3.3A)
None
 0.89A 4xv2B-4aw5A:
28.4		 4xv2B-4aw5A:
32.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 9 VAL A 105
ALA A 121
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.35A 5aaaA-4aw5A:
34.4		 5aaaA-4aw5A:
34.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 10 VAL A 105
ALA A 121
LYS A 123
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.48A 5aabA-4aw5A:
26.2		 5aabA-4aw5A:
34.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 10 VAL A 105
ALA A 121
LYS A 123
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.56A 5aacA-4aw5A:
33.8		 5aacA-4aw5A:
34.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 105
ALA A 121
LYS A 123
MET A 144
ILE A 153
THR A 169
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.93A 5bvwA-4aw5A:
26.8		 5bvwA-4aw5A:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 105
ALA A 121
ILE A 167
THR A 169
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.88A 5h2uB-4aw5A:
26.5		 5h2uB-4aw5A:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		5 / 12 VAL A 105
ALA A 121
ILE A 153
ILE A 167
THR A 169
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
 0.43A 5hesA-4aw5A:
11.1		 5hesA-4aw5A:
31.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		5 / 12 VAL A 105
ALA A 121
LYS A 123
ILE A 167
THR A 169
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
 0.27A 5hesB-4aw5A:
27.2		 5hesB-4aw5A:
31.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 ALA A 121
LYS A 123
GLU A 140
THR A 169
LEU A 207
HIS A 214
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
None
None
 0.87A 5hi2A-4aw5A:
28.4		 5hi2A-4aw5A:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 GLY A 100
VAL A 105
ALA A 121
LYS A 123
ILE A 167
THR A 169
 30K  A1365 ( 4.4A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
 0.69A 5hieA-4aw5A:
26.7		 5hieA-4aw5A:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 GLY A 100
VAL A 105
ALA A 121
LYS A 123
ILE A 167
THR A 169
 30K  A1365 ( 4.4A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
 0.71A 5hieB-4aw5A:
26.7		 5hieB-4aw5A:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 GLY A  98
GLY A 100
VAL A 105
ALA A 121
LYS A 123
THR A 169
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.4A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-3.8A)
 0.85A 5hieC-4aw5A:
26.9		 5hieC-4aw5A:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 GLY A 100
VAL A 105
ALA A 121
LYS A 123
ILE A 167
THR A 169
 30K  A1365 ( 4.4A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
 0.70A 5hieD-4aw5A:
26.8		 5hieD-4aw5A:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		9 / 12 ILE A  97
ALA A 121
GLU A 140
ILE A 153
ILE A 167
THR A 169
GLY A 175
LEU A 223
SER A 233
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
 0.53A 5i9xA-4aw5A:
37.5		 5i9xA-4aw5A:
66.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		9 / 12 ILE A  97
ALA A 121
LYS A 123
GLU A 140
MET A 144
THR A 169
GLY A 175
LEU A 223
SER A 233
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
 0.67A 5i9yA-4aw5A:
32.1		 5i9yA-4aw5A:
66.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 9 ILE A  97
GLY A  98
VAL A 105
ALA A 121
ILE A 153
LEU A 223
 30K  A1365 (-4.5A)
30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-4.5A)
 1.41A 5lw1B-4aw5A:
20.8		 5lw1B-4aw5A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 9 ILE A  97
GLY A  98
VAL A 105
ALA A 121
ILE A 153
MET A 172
 30K  A1365 (-4.5A)
30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
 0.65A 5lw1B-4aw5A:
20.8		 5lw1B-4aw5A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		5 / 10 GLY A  98
VAL A 105
ALA A 121
ILE A 153
MET A 172
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
 0.65A 5lw1E-4aw5A:
20.6		 5lw1E-4aw5A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 GLU A  95
ILE A  97
GLY A  98
VAL A 105
ALA A 121
LYS A 123
GLU A 140
GLY A 175
 None
30K  A1365 (-4.5A)
30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
 0.74A 5mafA-4aw5A:
17.0		 5mafA-4aw5A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		5 / 10 VAL A 105
ILE A 167
PHE A 171
MET A 172
GLY A 175
 30K  A1365 ( 4.6A)
None
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
 0.65A 5mo4A-4aw5A:
25.0		 5mo4A-4aw5A:
26.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 GLY A 100
VAL A 105
ALA A 121
LYS A 123
ILE A 167
THR A 169
LEU A 223
 30K  A1365 ( 4.4A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
 0.65A 5p9iA-4aw5A:
27.5		 5p9iA-4aw5A:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 VAL A 105
ALA A 121
ILE A 167
THR A 169
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.41A 5p9iA-4aw5A:
27.5		 5p9iA-4aw5A:
38.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		3 / 3 HIS A 214
SER A 233
ARG A 220
 None
30K  A1365 ( 3.7A)
None
 1.02A 5u63A-4aw5A:
undetectable		 5u63A-4aw5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		6 / 12 GLU A  95
ILE A  97
GLY A  98
ALA A 121
GLY A 175
ASP A 234
 None
30K  A1365 (-4.5A)
30K  A1365 ( 3.9A)
30K  A1365 (-3.2A)
30K  A1365 (-3.5A)
30K  A1365 (-3.3A)
 0.68A 5vc3A-4aw5A:
24.0		 5vc3A-4aw5A:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		3 / 3 LYS A 123
LEU A 223
ASP A 234
 30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.81A 5zv2A-4aw5A:
27.9		 5zv2A-4aw5A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 105
ALA A 121
LYS A 123
MET A 144
ILE A 153
THR A 169
MET A 172
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.8A)
None
30K  A1365 (-4.5A)
 0.90A 6bsdA-4aw5A:
30.9		 6bsdA-4aw5A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		8 / 12 VAL A 105
ALA A 121
MET A 144
ILE A 153
THR A 169
MET A 172
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.85A 6bsdA-4aw5A:
30.9		 6bsdA-4aw5A:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		12 / 12 ILE A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
THR A 169
MET A 172
GLY A 175
LEU A 223
SER A 233
 30K  A1365 (-4.5A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
 0.48A 6fnmA-4aw5A:
40.9		 6fnmA-4aw5A:
97.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		5 / 9 ASP A 234
SER A 233
GLY A 293
SER A 291
VAL A 285
 30K  A1365 (-3.3A)
30K  A1365 ( 3.7A)
None
None
None
 1.40A 6giqA-4aw5A:
1.9
6giqE-4aw5A:
undetectable
6giqI-4aw5A:
undetectable		 6giqA-4aw5A:
21.87
6giqE-4aw5A:
21.82
6giqI-4aw5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 105
ALA A 121
GLU A 140
MET A 144
ILE A 167
THR A 169
PHE A 171
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
 0.76A 6hd6A-4aw5A:
31.9		 6hd6A-4aw5A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens) 		7 / 12 VAL A 105
ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
PHE A 171
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-4.4A)
 0.76A 6hd6A-4aw5A:
31.9		 6hd6A-4aw5A:
14.34