SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2YS'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N4F_A_ASRA141_0 (LYSOZYME C)	4q80	SERINE PROTEASE 57 (Homo sapiens)	5 / 6	ASP A 222 GLY A 221 THR A 224 PRO A 225 SER A 216	None None None None 2YS A 304 (-3.7A)	1.28A	1n4fA-4q80A: undetectable	1n4fA-4q80A: 20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBH_A_SAMA293_0 (GLYCINE N-METHYLTRANSFERASE)	4q80	SERINE PROTEASE 57 (Homo sapiens)	5 / 12	ILE A 16 GLY A 197 VAL A 138 SER A 54 HIS A 57	None None None None 2YS A 304 (-2.6A)	1.22A	1nbhA-4q80A: undetectable	1nbhA-4q80A: 24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBH_C_SAMC2293_0 (GLYCINE N-METHYLTRANSFERASE)	4q80	SERINE PROTEASE 57 (Homo sapiens)	5 / 12	ILE A 16 GLY A 197 VAL A 138 SER A 54 HIS A 57	None None None None 2YS A 304 (-2.6A)	1.23A	1nbhC-4q80A: undetectable	1nbhC-4q80A: 24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBH_D_SAMD3293_0 (GLYCINE N-METHYLTRANSFERASE)	4q80	SERINE PROTEASE 57 (Homo sapiens)	5 / 12	ILE A 16 GLY A 197 VAL A 138 SER A 54 HIS A 57	None None None None 2YS A 304 (-2.6A)	1.22A	1nbhD-4q80A: undetectable	1nbhD-4q80A: 24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QB9_A_PARA500_1 (ENHANCED INTRACELLULAR SURVIVAL PROTEIN)	4q80	SERINE PROTEASE 57 (Homo sapiens)	5 / 10	SER A 145 PHE A 148 SER A 192 ASP A 226 GLY A 221	None None 2YS A 304 (-4.4A) None None	1.44A	4qb9A-4q80A: undetectable	4qb9A-4q80A: 22.22

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1N4F_A_ASRA141_0","LYSOZYME C","4q80","SERINE PROTEASE 57","Homo sapiens",5,"ASP A 222;GLY A 221;THR A 224;PRO A 225;SER A 216","None;None;None;None;2YS A 304 (-3.7A)","1.28A","1n4fA-4q80A:undetectable",null],["1NBH_A_SAMA293_0","GLYCINE N-METHYLTRANSFERASE","4q80","SERINE PROTEASE 57","Homo sapiens",5,"ILE A  16;GLY A 197;VAL A 138;SER A  54;HIS A  57","None;None;None;None;2YS A 304 (-2.6A)","1.22A","1nbhA-4q80A:undetectable","1n4fA-4q80A:20.63"],["1NBH_C_SAMC2293_0","GLYCINE N-METHYLTRANSFERASE","4q80","SERINE PROTEASE 57","Homo sapiens",5,"ILE A  16;GLY A 197;VAL A 138;SER A  54;HIS A  57","None;None;None;None;2YS A 304 (-2.6A)","1.23A","1nbhC-4q80A:undetectable","1nbhA-4q80A:24.53"],["1NBH_D_SAMD3293_0","GLYCINE N-METHYLTRANSFERASE","4q80","SERINE PROTEASE 57","Homo sapiens",5,"ILE A  16;GLY A 197;VAL A 138;SER A  54;HIS A  57","None;None;None;None;2YS A 304 (-2.6A)","1.22A","1nbhD-4q80A:undetectable","1nbhC-4q80A:24.53"],["4QB9_A_PARA500_1","ENHANCED INTRACELLULAR SURVIVAL PROTEIN","4q80","SERINE PROTEASE 57","Homo sapiens",5,"SER A 145;PHE A 148;SER A 192;ASP A 226;GLY A 221","None;None;2YS A 304 (-4.4A);None;None","1.44A","4qb9A-4q80A:undetectable","1nbhD-4q80A:24.53"]]