SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2W4'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 PRO A1264
GLY A2061
ALA A2112
GLN A2031
 2W4  A2205 (-4.4A)
2W4  A2205 (-4.9A)
None
2W4  A2205 ( 4.1A)
 1.12A 4g0uA-4pivA:
undetectable		 4g0uA-4pivA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 7 SER A2021
GLN A2031
TYR A2034
LEU A2069
 2W4  A2205 (-2.7A)
2W4  A2205 ( 4.1A)
2W4  A2205 ( 4.4A)
NDP  A2202 ( 3.5A)
 0.83A 4hxyB-4pivA:
36.1		 4hxyB-4pivA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A1895
GLY A1897
ALA A1901
ILE A2068
VAL A2070
 NDP  A2202 (-3.6A)
None
None
2W4  A2205 (-3.9A)
None
 1.06A 6iftA-4pivA:
9.1		 6iftA-4pivA:
18.22