SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2UF'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I7Z_A_COCA301_1 (CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION)	4pbq	PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN (Haemophilus influenzae)	4 / 8	TYR A 262 TYR A 142 LEU A 120 GLU A 105	None None None 2UF A 401 (-2.8A)	1.01A	1i7zA-4pbqA: undetectable	1i7zA-4pbqA: 21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_D_ZPCD1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	4pbq	PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN (Haemophilus influenzae)	4 / 7	GLU A 207 PHE A 175 HIS A 32 VAL A 77	None 2UF A 401 (-4.5A) None None	0.92A	4a97D-4pbqA: undetectable	4a97D-4pbqA: 22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K17_B_OHBB701_0 (LEUCINE-RICH REPEAT-CONTAINING PROTEIN 16A)	4pbq	PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN (Haemophilus influenzae)	4 / 5	GLU A 207 ARG A 148 PRO A 170 SER A 188	None 2UF A 401 (-2.9A) 2UF A 401 (-4.3A) None	1.38A	4k17B-4pbqA: undetectable	4k17B-4pbqA: 19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GTR_A_ESTA601_2 (ESTROGEN RECEPTOR)	4pbq	PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN (Haemophilus influenzae)	4 / 5	LEU A 109 LEU A 92 PHE A 110 LEU A 120	None 2UF A 401 (-4.3A) None None	0.97A	5gtrA-4pbqA: undetectable	5gtrA-4pbqA: 20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDH_A_DAHA60_1 (PUTATIVE CYTOCHROME C)	4pbq	PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN (Haemophilus influenzae)	4 / 6	HIS A 230 ASN A 172 VAL A 169 LEU A 167	None 2UF A 401 (-3.9A) None None	1.34A	5xdhA-4pbqA: undetectable 5xdhC-4pbqA: undetectable	5xdhA-4pbqA: 14.98 5xdhC-4pbqA: 14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDH_B_DAHB60_1 (PUTATIVE CYTOCHROME C)	4pbq	PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN (Haemophilus influenzae)	4 / 5	HIS A 230 ASN A 172 VAL A 169 LEU A 167	None 2UF A 401 (-3.9A) None None	1.29A	5xdhB-4pbqA: undetectable	5xdhB-4pbqA: 14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDH_D_DAHD60_1 (PUTATIVE CYTOCHROME C)	4pbq	PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN (Haemophilus influenzae)	4 / 5	HIS A 230 ASN A 172 VAL A 169 LEU A 167	None 2UF A 401 (-3.9A) None None	1.35A	5xdhD-4pbqA: undetectable	5xdhD-4pbqA: 14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB302_1 (BIFUNCTIONAL PROTEIN FOLD)	4pbq	PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN (Haemophilus influenzae)	5 / 12	LEU A 218 PRO A 170 ILE A 203 VAL A 202 THR A 196	None 2UF A 401 (-4.3A) None None None	1.21A	6debB-4pbqA: undetectable	6debB-4pbqA: 12.81

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1I7Z_A_COCA301_1","CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION","4pbq","PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN","Haemophilus influenzae",4,"TYR A 262;TYR A 142;LEU A 120;GLU A 105","None;None;None;2UF A 401 (-2.8A)","1.01A","1i7zA-4pbqA:undetectable",null],["4A97_D_ZPCD1318_2","CYS-LOOP LIGAND-GATED ION CHANNEL","4pbq","PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN","Haemophilus influenzae",4,"GLU A 207;PHE A 175;HIS A  32;VAL A  77","None;2UF A 401 (-4.5A);None;None","0.92A","4a97D-4pbqA:undetectable","1i7zA-4pbqA:21.56"],["4K17_B_OHBB701_0","LEUCINE-RICH REPEAT-CONTAINING PROTEIN 16A","4pbq","PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN","Haemophilus influenzae",4,"GLU A 207;ARG A 148;PRO A 170;SER A 188","None;2UF A 401 (-2.9A);2UF A 401 (-4.3A);None","1.38A","4k17B-4pbqA:undetectable","4a97D-4pbqA:22.35"],["5GTR_A_ESTA601_2","ESTROGEN RECEPTOR","4pbq","PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN","Haemophilus influenzae",4,"LEU A 109;LEU A  92;PHE A 110;LEU A 120","None;2UF A 401 (-4.3A);None;None","0.97A","5gtrA-4pbqA:undetectable","4k17B-4pbqA:19.76"],["5XDH_A_DAHA60_1","PUTATIVE CYTOCHROME C;PUTATIVE CYTOCHROME C","4pbq","PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN","Haemophilus influenzae",4,"HIS A 230;ASN A 172;VAL A 169;LEU A 167","None;2UF A 401 (-3.9A);None;None","1.34A","5xdhA-4pbqA:undetectable;5xdhC-4pbqA:undetectable","5gtrA-4pbqA:20.96"],["5XDH_B_DAHB60_1","PUTATIVE CYTOCHROME C","4pbq","PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN","Haemophilus influenzae",4,"HIS A 230;ASN A 172;VAL A 169;LEU A 167","None;2UF A 401 (-3.9A);None;None","1.29A","5xdhB-4pbqA:undetectable","5xdhA-4pbqA:14.98;5xdhC-4pbqA:14.98"],["5XDH_D_DAHD60_1","PUTATIVE CYTOCHROME C","4pbq","PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN","Haemophilus influenzae",4,"HIS A 230;ASN A 172;VAL A 169;LEU A 167","None;2UF A 401 (-3.9A);None;None","1.35A","5xdhD-4pbqA:undetectable","5xdhB-4pbqA:14.98"],["6DEB_B_MTXB302_1","BIFUNCTIONAL PROTEIN FOLD","4pbq","PUTATIVE TRAP PERIPLASMIC SOLUTE BINDING PROTEIN","Haemophilus influenzae",5,"LEU A 218;PRO A 170;ILE A 203;VAL A 202;THR A 196","None;2UF A 401 (-4.3A);None;None;None","1.21A","6debB-4pbqA:undetectable","5xdhD-4pbqA:14.98"]]