SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2U9'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 12 ILE C  37
GLY C 228
VAL C 130
ALA C 176
MET C 202
 None
2U9  C 301 (-3.6A)
None
None
None
 1.20A 1kiaB-4p74C:
undetectable		 1kiaB-4p74C:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 12 ILE C  37
GLY C 228
VAL C 130
ALA C 176
MET C 202
 None
2U9  C 301 (-3.6A)
None
None
None
 1.19A 1nbhA-4p74C:
undetectable		 1nbhA-4p74C:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 12 ILE C  37
GLY C 228
VAL C 130
ALA C 176
MET C 202
 None
2U9  C 301 (-3.6A)
None
None
None
 1.20A 1nbhC-4p74C:
undetectable		 1nbhC-4p74C:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 12 ILE C  37
GLY C 228
VAL C 130
ALA C 176
MET C 202
 None
2U9  C 301 (-3.6A)
None
None
None
 1.19A 1nbhD-4p74C:
undetectable		 1nbhD-4p74C:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT
(Pseudomonas
aeruginosa) 		9 / 12 ARG C 116
GLN C 129
PHE C 169
PHE C 171
THR C 172
GLY C 203
GLY C 205
ALA C 226
GLY C 228
 2U9  C 301 ( 4.2A)
2U9  C 301 (-3.6A)
2U9  C 301 (-3.9A)
2U9  C 301 (-4.2A)
2U9  C 301 ( 4.2A)
2U9  C 301 (-3.2A)
None
2U9  C 301 (-3.3A)
2U9  C 301 (-3.6A)
 0.64A 3tegA-4p74C:
25.0		 3tegA-4p74C:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT
(Pseudomonas
aeruginosa) 		8 / 12 GLU C 131
PHE C 169
PHE C 171
THR C 172
GLY C 203
GLY C 205
ALA C 226
GLY C 228
 2U9  C 301 (-3.4A)
2U9  C 301 (-3.9A)
2U9  C 301 (-4.2A)
2U9  C 301 ( 4.2A)
2U9  C 301 (-3.2A)
None
2U9  C 301 (-3.3A)
2U9  C 301 (-3.6A)
 0.73A 3tegA-4p74C:
25.0		 3tegA-4p74C:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT
(Pseudomonas
aeruginosa) 		9 / 12 SER C  92
ARG C 116
GLN C 129
PHE C 169
PHE C 171
THR C 172
GLY C 205
ALA C 226
GLY C 228
 2U9  C 301 (-3.6A)
2U9  C 301 ( 4.2A)
2U9  C 301 (-3.6A)
2U9  C 301 (-3.9A)
2U9  C 301 (-4.2A)
2U9  C 301 ( 4.2A)
None
2U9  C 301 (-3.3A)
2U9  C 301 (-3.6A)
 0.70A 3tegA-4p74C:
25.0		 3tegA-4p74C:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT
(Pseudomonas
aeruginosa) 		6 / 12 SER C  92
GLN C  95
ARG C 116
GLN C 129
ALA C 226
GLY C 228
 2U9  C 301 (-3.6A)
2U9  C 301 (-3.9A)
2U9  C 301 ( 4.2A)
2U9  C 301 (-3.6A)
2U9  C 301 (-3.3A)
2U9  C 301 (-3.6A)
 1.37A 3tegA-4p74C:
25.0		 3tegA-4p74C:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT
(Pseudomonas
aeruginosa) 		8 / 12 SER C  92
GLU C 131
PHE C 169
PHE C 171
THR C 172
GLY C 205
ALA C 226
GLY C 228
 2U9  C 301 (-3.6A)
2U9  C 301 (-3.4A)
2U9  C 301 (-3.9A)
2U9  C 301 (-4.2A)
2U9  C 301 ( 4.2A)
None
2U9  C 301 (-3.3A)
2U9  C 301 (-3.6A)
 0.96A 3tegA-4p74C:
25.0		 3tegA-4p74C:
27.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT
(Pseudomonas
aeruginosa) 		7 / 9 HIS C  90
SER C  92
ARG C 116
GLN C 129
GLU C 131
ALA C 226
GLY C 228
 None
2U9  C 301 (-3.6A)
2U9  C 301 ( 4.2A)
2U9  C 301 (-3.6A)
2U9  C 301 (-3.4A)
2U9  C 301 (-3.3A)
2U9  C 301 (-3.6A)
 0.92A 3tehA-4p74C:
28.7		 3tehA-4p74C:
47.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT
(Pseudomonas
aeruginosa) 		5 / 9 HIS C  90
SER C  92
GLU C 131
VAL C 207
ALA C 226
 None
2U9  C 301 (-3.6A)
2U9  C 301 (-3.4A)
2U9  C 301 ( 4.6A)
2U9  C 301 (-3.3A)
 1.48A 3tehA-4p74C:
28.7		 3tehA-4p74C:
47.27