SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2TX'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VW7_A_VPXA2001_1 (PROTEINASE-ACTIVATED RECEPTOR 1, LYSOZYME)	4omj	SEC14-LIKE PROTEIN 2 (Homo sapiens)	5 / 12	TYR A 153 LEU A 189 PHE A 198 ALA A 167 TYR A 171	2TX A 310 (-4.3A) 2TX A 310 (-4.8A) 2TX A 310 (-4.7A) 2TX A 310 (-3.9A) 2TX A 310 (-4.1A)	1.17A	3vw7A-4omjA: undetectable	3vw7A-4omjA: 18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WQ5_B_ACTB404_0 (TRNA N6-ADENOSINE THREONYLCARBAMOYLTRA NSFERASE)	4omj	SEC14-LIKE PROTEIN 2 (Homo sapiens)	3 / 3	TYR A 202 ARG A 214 LYS A 206	2TX A 310 (-4.9A) CL A 306 (-3.4A) CL A 306 ( 3.7A)	1.34A	4wq5B-4omjA: undetectable	4wq5B-4omjA: 22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CR1_A_T44A201_1 (TRANSTHYRETIN)	4omj	SEC14-LIKE PROTEIN 2 (Homo sapiens)	4 / 5	LEU A 158 ALA A 194 LEU A 197 VAL A 219	2TX A 310 ( 4.4A) None None None	1.19A	5cr1A-4omjA: undetectable	5cr1A-4omjA: 22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MUR_B_PFLB407_1 (PROTON-GATED ION CHANNEL)	4omj	SEC14-LIKE PROTEIN 2 (Homo sapiens)	4 / 7	TYR A 153 ILE A 151 ILE A 152 ILE A 258	2TX A 310 (-4.3A) 2TX A 310 ( 4.4A) None None	0.87A	5murB-4omjA: undetectable	5murB-4omjA: 14.03

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3VW7_A_VPXA2001_1","PROTEINASE-ACTIVATED RECEPTOR 1, LYSOZYME","4omj","SEC14-LIKE PROTEIN 2","Homo sapiens",5,"TYR A 153;LEU A 189;PHE A 198;ALA A 167;TYR A 171","2TX A 310 (-4.3A);2TX A 310 (-4.8A);2TX A 310 (-4.7A);2TX A 310 (-3.9A);2TX A 310 (-4.1A)","1.17A","3vw7A-4omjA:undetectable",null],["4WQ5_B_ACTB404_0","TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE","4omj","SEC14-LIKE PROTEIN 2","Homo sapiens",3,"TYR A 202;ARG A 214;LYS A 206","2TX A 310 (-4.9A); CL A 306 (-3.4A); CL A 306 ( 3.7A)","1.34A","4wq5B-4omjA:undetectable","3vw7A-4omjA:18.89"],["5CR1_A_T44A201_1","TRANSTHYRETIN","4omj","SEC14-LIKE PROTEIN 2","Homo sapiens",4,"LEU A 158;ALA A 194;LEU A 197;VAL A 219","2TX A 310 ( 4.4A);None;None;None","1.19A","5cr1A-4omjA:undetectable","4wq5B-4omjA:22.01"],["5MUR_B_PFLB407_1","PROTON-GATED ION CHANNEL","4omj","SEC14-LIKE PROTEIN 2","Homo sapiens",4,"TYR A 153;ILE A 151;ILE A 152;ILE A 258","2TX A 310 (-4.3A);2TX A 310 ( 4.4A);None;None","0.87A","5murB-4omjA:undetectable","5cr1A-4omjA:22.35"]]