SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2TT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
VAL A 981
ASN A1028
LEU A1030
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-3.7A)
2TT  A1202 (-4.5A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.67A 1fmoE-4oliA:
24.2		 1fmoE-4oliA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
ALA A 928
LYS A 930
GLU A 947
LEU A 976
GLY A 984
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
None
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.99A 1m17A-4oliA:
31.6		 1m17A-4oliA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 9 LEU A 903
GLY A 904
VAL A 911
ALA A 928
TYR A 980
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
 0.75A 1muoA-4oliA:
7.8		 1muoA-4oliA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
VAL A 911
ALA A 928
GLU A 947
LEU A 951
GLY A 984
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.57A 1t46A-4oliA:
27.5		 1t46A-4oliA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 ALA A 928
GLU A 947
LEU A 951
LEU A1014
HIS A1021
GLY A1040
 2TT  A1202 ( 3.9A)
None
None
None
None
2TT  A1202 (-3.4A)
 0.93A 1uwhA-4oliA:
26.4		 1uwhA-4oliA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 ALA A 928
LYS A 930
GLU A 947
LEU A 951
LEU A1014
HIS A1021
GLY A1040
 2TT  A1202 ( 3.9A)
None
None
None
None
None
2TT  A1202 (-3.4A)
 0.95A 1uwhB-4oliA:
26.3		 1uwhB-4oliA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 SER A 580
GLY A 984
LEU A 983
ARG A 901
VAL A 673
 None
2TT  A1202 (-3.4A)
None
2TT  A1202 ( 4.8A)
None
 1.26A 1vpoH-4oliA:
undetectable
1vpoL-4oliA:
undetectable		 1vpoH-4oliA:
18.15
1vpoL-4oliA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 9 LEU A 595
VAL A 603
GLY A 693
PRO A 694
LEU A 741
 2TT  A1201 (-4.1A)
2TT  A1201 (-4.2A)
2TT  A1201 (-3.5A)
2TT  A1201 ( 4.4A)
2TT  A1201 (-4.1A)
 0.54A 1xbbA-4oliA:
28.9		 1xbbA-4oliA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 11 GLY A 904
GLY A 906
VAL A 911
ALA A 928
MET A 978
TYR A 980
SER A 985
LEU A1030
 2TT  A1202 ( 4.2A)
2TT  A1202 ( 3.8A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.6A)
None
2TT  A1202 (-4.4A)
 0.66A 2evaA-4oliA:
26.3		 2evaA-4oliA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
VAL A 981
ASN A1028
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-3.7A)
2TT  A1202 (-4.5A)
2TT  A1202 (-4.6A)
 0.53A 2fumA-4oliA:
24.9		 2fumA-4oliA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		9 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
MET A 978
TYR A 980
VAL A 981
ASN A1028
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.6A)
2TT  A1202 (-3.7A)
2TT  A1202 (-4.5A)
2TT  A1202 (-4.6A)
 0.62A 2fumB-4oliA:
24.9		 2fumB-4oliA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
MET A 978
TYR A 980
VAL A 981
ASN A1028
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.6A)
2TT  A1202 (-3.7A)
2TT  A1202 (-4.5A)
 0.49A 2fumC-4oliA:
24.7		 2fumC-4oliA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
ALA A 928
GLU A 947
LEU A 976
GLY A 984
ASP A 988
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
None
2TT  A1202 (-4.4A)
 0.93A 2itoA-4oliA:
29.5		 2itoA-4oliA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 9 LEU A 903
ALA A 928
GLY A 984
LEU A1030
GLY A1040
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.6A)
 0.72A 2xp2A-4oliA:
28.6		 2xp2A-4oliA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 10 VAL A 911
ALA A 928
ILE A 960
GLY A 984
ASP A 988
LEU A1030
 2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 (-3.4A)
None
2TT  A1202 (-4.4A)
 0.74A 2y7jC-4oliA:
25.9		 2y7jC-4oliA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 6 LEU A 595
VAL A 603
LYS A 642
LEU A 741
 2TT  A1201 (-4.1A)
2TT  A1201 (-4.2A)
2TT  A1201 ( 4.6A)
2TT  A1201 (-4.1A)
 0.89A 3cs9D-4oliA:
26.3		 3cs9D-4oliA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 6 LEU A 903
VAL A 911
LYS A 930
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
2TT  A1202 (-4.4A)
 0.85A 3cs9D-4oliA:
26.3		 3cs9D-4oliA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		10 / 12 LEU A 903
GLY A 904
GLY A 906
GLY A 909
VAL A 911
ALA A 928
MET A 978
SER A 985
ASN A1028
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 ( 3.8A)
None
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 ( 4.4A)
None
2TT  A1202 (-4.5A)
2TT  A1202 (-4.4A)
 0.66A 3eygA-4oliA:
38.5		 3eygA-4oliA:
29.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		9 / 12 LEU A 903
GLY A 904
GLY A 906
GLY A 909
VAL A 911
SER A 985
ASN A1028
LEU A1030
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 ( 3.8A)
None
2TT  A1202 (-4.5A)
None
2TT  A1202 (-4.5A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.81A 3eygA-4oliA:
38.5		 3eygA-4oliA:
29.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		10 / 12 LEU A 903
GLY A 904
GLY A 906
VAL A 911
ALA A 928
LYS A 930
MET A 978
SER A 985
ASN A1028
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 ( 3.8A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 ( 4.4A)
None
2TT  A1202 (-4.5A)
2TT  A1202 (-4.4A)
 0.77A 3eygA-4oliA:
38.5		 3eygA-4oliA:
29.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		10 / 12 LEU A 903
GLY A 904
GLY A 906
GLY A 909
VAL A 911
ALA A 928
LYS A 930
MET A 978
TYR A 980
SER A 985
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 ( 3.8A)
None
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.6A)
None
 0.65A 3fupA-4oliA:
38.7		 3fupA-4oliA:
50.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		10 / 12 LEU A 903
GLY A 904
GLY A 909
VAL A 911
ALA A 928
LYS A 930
MET A 978
TYR A 980
SER A 985
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
None
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.6A)
None
2TT  A1202 (-4.4A)
 0.62A 3fupA-4oliA:
38.7		 3fupA-4oliA:
50.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
GLY A 904
GLY A 909
VAL A 911
TYR A 980
SER A 985
LEU A1030
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
None
2TT  A1202 (-4.5A)
2TT  A1202 (-4.6A)
None
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.79A 3fupA-4oliA:
38.7		 3fupA-4oliA:
50.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
MET A 978
TYR A 980
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
 0.53A 3fupB-4oliA:
38.6		 3fupB-4oliA:
50.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 11 LEU A 903
VAL A 911
ALA A 928
TYR A 980
GLY A 984
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.51A 3g0eA-4oliA:
25.1		 3g0eA-4oliA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 11 LEU A 903
VAL A 911
ALA A 928
TYR A 980
GLY A 984
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.58A 3g0fA-4oliA:
26.6		 3g0fA-4oliA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 10 LEU A 595
VAL A 603
THR A 687
TYR A 689
GLY A 693
LEU A 741
 2TT  A1201 (-4.1A)
2TT  A1201 (-4.2A)
None
2TT  A1201 (-4.0A)
2TT  A1201 (-3.5A)
2TT  A1201 (-4.1A)
 0.82A 3g0fB-4oliA:
27.0		 3g0fB-4oliA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 10 LEU A 903
VAL A 911
ALA A 928
TYR A 980
GLY A 984
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.48A 3g0fB-4oliA:
27.0		 3g0fB-4oliA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 VAL A 911
ALA A 928
GLU A 947
LEU A 951
ILE A 960
HIS A1021
 2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
None
None
 1.05A 3gp0A-4oliA:
21.1		 3gp0A-4oliA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 VAL A 981
GLU A 979
LEU A 990
ARG A 987
GLY A1040
 2TT  A1202 (-3.7A)
None
None
None
2TT  A1202 (-3.4A)
 1.31A 3j6pB-4oliA:
undetectable		 3j6pB-4oliA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
MET A 978
TYR A 980
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
 0.67A 3lxkA-4oliA:
37.7		 3lxkA-4oliA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
GLY A 904
GLY A 906
VAL A 911
ALA A 928
TYR A 980
VAL A 981
SER A 985
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 ( 3.8A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-3.7A)
None
 0.60A 3lxnA-4oliA:
39.8		 3lxnA-4oliA:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
GLY A 904
ILE A 960
VAL A 981
SER A 985
LEU A1030
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
None
2TT  A1202 (-3.7A)
None
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.65A 3lxnA-4oliA:
39.8		 3lxnA-4oliA:
47.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		10 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
ILE A 960
TYR A 980
VAL A 981
SER A 985
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-3.7A)
None
2TT  A1202 (-4.4A)
 0.57A 3lxnA-4oliA:
39.8		 3lxnA-4oliA:
47.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 595
VAL A 603
LYS A 642
THR A 687
TYR A 689
GLY A 693
LEU A 741
 2TT  A1201 (-4.1A)
2TT  A1201 (-4.2A)
2TT  A1201 ( 4.6A)
None
2TT  A1201 (-4.0A)
2TT  A1201 (-3.5A)
2TT  A1201 (-4.1A)
 0.71A 3octA-4oliA:
26.3		 3octA-4oliA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 ALA A 928
LYS A 930
LEU A 976
MET A 978
GLY A 984
ASP A 988
LEU A1030
 2TT  A1202 ( 3.9A)
None
None
2TT  A1202 ( 4.4A)
2TT  A1202 (-3.4A)
None
2TT  A1202 (-4.4A)
 0.91A 3ug2A-4oliA:
31.5		 3ug2A-4oliA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 LEU A 903
VAL A 911
ALA A 928
GLU A 947
LEU A 951
GLY A 984
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
 0.57A 3wzdA-4oliA:
27.7		 3wzdA-4oliA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 5 LYS A 930
ILE A 950
LEU A1030
ASP A1041
 None
None
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 1.16A 3wzdA-4oliA:
27.7		 3wzdA-4oliA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
VAL A 911
ALA A 928
GLU A 947
LEU A 951
GLY A 984
LEU A1014
HIS A1021
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
None
None
 0.76A 3wzeA-4oliA:
27.9		 3wzeA-4oliA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 ALA A 928
GLY A 984
LEU A1030
GLY A1040
ASP A1041
 2TT  A1202 ( 3.9A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.6A)
 0.53A 3zbfA-4oliA:
28.4		 3zbfA-4oliA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 9 ILE A 950
ILE A 959
ILE A 960
TYR A 980
ILE A1039
 None
None
None
2TT  A1202 (-4.6A)
None
 0.58A 3zosA-4oliA:
26.1		 3zosA-4oliA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 9 LEU A 903
ILE A 950
ILE A 959
TYR A 980
ILE A1039
 2TT  A1202 (-3.5A)
None
None
2TT  A1202 (-4.6A)
None
 0.58A 3zosB-4oliA:
26.3		 3zosB-4oliA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 9 LEU A 903
ILE A 950
LEU A 954
ILE A 959
ILE A1039
 2TT  A1202 (-3.5A)
None
None
None
None
 0.74A 3zosB-4oliA:
26.3		 3zosB-4oliA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.72A 4ag8A-4oliA:
28.0		 4ag8A-4oliA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 LEU A 903
VAL A 911
ALA A 928
GLU A 947
GLY A 984
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.45A 4agcA-4oliA:
27.5		 4agcA-4oliA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 9 LEU A 903
VAL A 911
ALA A 928
MET A 978
GLY A 984
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 ( 4.4A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.71A 4ansA-4oliA:
27.1		 4ansA-4oliA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
VAL A 911
ALA A 928
GLU A 947
LEU A 951
GLY A 984
LEU A1014
HIS A1021
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
None
None
 0.95A 4asdA-4oliA:
27.5		 4asdA-4oliA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 5 VAL A 911
ILE A 959
TYR A 980
ILE A1039
 2TT  A1202 (-4.5A)
None
2TT  A1202 (-4.6A)
None
 0.68A 4c8bA-4oliA:
25.5		 4c8bA-4oliA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 10 LEU A 903
GLY A 904
VAL A 911
ALA A 928
TYR A 980
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
 0.46A 4ckjA-4oliA:
31.9		 4ckjA-4oliA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 10 LEU A 903
VAL A 911
ALA A 928
TYR A 980
SER A 985
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
None
2TT  A1202 (-4.4A)
 0.48A 4ckjA-4oliA:
31.9		 4ckjA-4oliA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 LEU A 595
VAL A 603
LYS A 642
THR A 687
GLY A 693
LEU A 741
 2TT  A1201 (-4.1A)
2TT  A1201 (-4.2A)
2TT  A1201 ( 4.6A)
None
2TT  A1201 (-3.5A)
2TT  A1201 (-4.1A)
 0.52A 4hjoA-4oliA:
28.7		 4hjoA-4oliA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		9 / 12 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
LEU A 976
GLY A 984
ASP A 988
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
None
2TT  A1202 (-4.4A)
 0.98A 4i22A-4oliA:
27.2		 4i22A-4oliA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 595
VAL A 603
LYS A 642
THR A 687
TYR A 689
GLY A 693
LEU A 741
 2TT  A1201 (-4.1A)
2TT  A1201 (-4.2A)
2TT  A1201 ( 4.6A)
None
2TT  A1201 (-4.0A)
2TT  A1201 (-3.5A)
2TT  A1201 (-4.1A)
 0.52A 4mxxB-4oliA:
26.3		 4mxxB-4oliA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 6 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.4A)
 0.41A 4o0wA-4oliA:
24.9		 4o0wA-4oliA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 7 GLY A 904
ALA A 928
ASN A1028
LEU A1030
ASP A1041
 2TT  A1202 ( 4.2A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.5A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.66A 4ogrE-4oliA:
25.1		 4ogrE-4oliA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 9 GLY A 906
VAL A 911
ALA A 928
ASN A1028
LEU A1030
ASP A1041
 2TT  A1202 ( 3.8A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.5A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.74A 4ogrI-4oliA:
26.3		 4ogrI-4oliA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 LEU A 595
VAL A 603
LYS A 642
THR A 687
TYR A 689
GLY A 693
LEU A 741
 2TT  A1201 (-4.1A)
2TT  A1201 (-4.2A)
2TT  A1201 ( 4.6A)
None
2TT  A1201 (-4.0A)
2TT  A1201 (-3.5A)
2TT  A1201 (-4.1A)
 0.61A 4otwA-4oliA:
27.9		 4otwA-4oliA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 ALA A 928
LYS A 930
GLU A 947
TYR A 980
LEU A1030
ASP A1041
 2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.82A 4qmnA-4oliA:
26.7		 4qmnA-4oliA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLY A 984
ASN A1028
LEU A1030
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.5A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.73A 4twpA-4oliA:
31.5		 4twpA-4oliA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLY A 984
ASN A1028
LEU A1030
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.5A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.72A 4twpB-4oliA:
30.8		 4twpB-4oliA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 6 LEU A 903
VAL A 911
LYS A 930
ILE A 959
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
 0.67A 4tyjA-4oliA:
28.0		 4tyjA-4oliA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 6 LEU A 903
VAL A 911
LYS A 930
ILE A 959
ILE A1039
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
None
 0.61A 4tyjA-4oliA:
28.0		 4tyjA-4oliA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 10 LEU A 903
VAL A 911
GLU A 947
LEU A 954
ILE A 959
TYR A 980
ILE A1039
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
None
2TT  A1202 (-4.6A)
None
 0.75A 4u0iA-4oliA:
27.2		 4u0iA-4oliA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 9 LEU A 903
VAL A 911
ALA A 928
TYR A 980
GLY A 984
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.69A 4u5jB-4oliA:
28.7		 4u5jB-4oliA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 7 VAL A 911
LYS A 930
ILE A 960
ILE A1039
 2TT  A1202 (-4.5A)
None
None
None
 0.59A 4uxqA-4oliA:
28.0		 4uxqA-4oliA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 9 LEU A 903
VAL A 911
LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A 959
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
None
 1.22A 4v01A-4oliA:
27.4		 4v01A-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 9 LEU A 903
VAL A 911
LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A1039
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
None
 0.71A 4v01A-4oliA:
27.4		 4v01A-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 9 LYS A 930
ILE A 960
TYR A 980
ARG A1022
LEU A1030
ILE A1039
 None
None
2TT  A1202 (-4.6A)
None
2TT  A1202 (-4.4A)
None
 1.16A 4v01A-4oliA:
27.4		 4v01A-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 9 LEU A 903
VAL A 911
LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A 959
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
None
 1.43A 4v01B-4oliA:
27.5		 4v01B-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 9 LEU A 903
VAL A 911
LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A1039
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
None
 0.81A 4v01B-4oliA:
27.5		 4v01B-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 8 ILE A 960
TYR A 980
ARG A1022
LEU A1030
ILE A1039
 None
2TT  A1202 (-4.6A)
None
2TT  A1202 (-4.4A)
None
 1.46A 4v04A-4oliA:
26.9		 4v04A-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 8 LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A1039
 None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
None
 0.72A 4v04A-4oliA:
26.9		 4v04A-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 10 LEU A 903
LYS A 930
ILE A 960
TYR A 980
ARG A1022
LEU A1030
ILE A1039
 2TT  A1202 (-3.5A)
None
None
2TT  A1202 (-4.6A)
None
2TT  A1202 (-4.4A)
None
 1.30A 4v04B-4oliA:
27.0		 4v04B-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 10 LEU A 903
VAL A 911
LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A 959
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
None
 1.21A 4v04B-4oliA:
27.0		 4v04B-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 10 LEU A 903
VAL A 911
LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A1039
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
None
 0.75A 4v04B-4oliA:
27.0		 4v04B-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 8 LEU A 903
ALA A 928
MET A 978
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.4A)
 0.65A 4wboB-4oliA:
22.5		 4wboB-4oliA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 6 ARG A 901
LEU A 903
ALA A 928
MET A 978
LEU A1030
 2TT  A1202 ( 4.8A)
2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.4A)
 1.02A 4wboC-4oliA:
16.8		 4wboC-4oliA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
ALA A 928
LYS A 930
GLU A 947
LEU A 976
GLY A 984
ASP A 988
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
None
None
None
2TT  A1202 (-3.4A)
None
2TT  A1202 (-4.4A)
 0.99A 4wkqA-4oliA:
32.5		 4wkqA-4oliA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 VAL A 911
ALA A 928
GLY A1040
ASP A1041
PHE A1042
 2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.6A)
None
 0.71A 4xv2A-4oliA:
26.8		 4xv2A-4oliA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 ALA A 928
LEU A 951
GLY A1040
ASP A1041
PHE A1042
 2TT  A1202 ( 3.9A)
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.6A)
None
 0.96A 4xv2B-4oliA:
27.0		 4xv2B-4oliA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 9 LEU A 903
ALA A 928
GLY A 984
LEU A1030
GLY A1040
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.6A)
 0.71A 5aaaA-4oliA:
27.4		 5aaaA-4oliA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 10 LEU A 903
ALA A 928
LYS A 930
GLY A 984
LEU A1030
GLY A1040
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.6A)
 0.76A 5aabA-4oliA:
27.5		 5aabA-4oliA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 10 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLY A 984
LEU A1030
GLY A1040
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
2TT  A1202 (-3.4A)
 0.92A 5aacA-4oliA:
28.7		 5aacA-4oliA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		9 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
ILE A 960
TYR A 980
GLY A 984
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.70A 5bvwA-4oliA:
25.9		 5bvwA-4oliA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 GLY A 596
GLY A 598
VAL A 603
LYS A 642
THR A 687
 2TT  A1201 (-3.3A)
2TT  A1201 ( 4.4A)
2TT  A1201 (-4.2A)
2TT  A1201 ( 4.6A)
None
 0.50A 5hieC-4oliA:
26.0		 5hieC-4oliA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 GLY A 904
GLY A 906
VAL A 911
ALA A 928
GLY A1040
ASP A1041
 2TT  A1202 ( 4.2A)
2TT  A1202 ( 3.8A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.6A)
 0.83A 5hieC-4oliA:
26.0		 5hieC-4oliA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 GLY A 904
GLY A 906
VAL A 911
ALA A 928
LYS A 930
ASP A1041
 2TT  A1202 ( 4.2A)
2TT  A1202 ( 3.8A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 (-4.6A)
 0.77A 5hieC-4oliA:
26.0		 5hieC-4oliA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 ASP A 696
GLY A 737
ASN A 739
ALA A 671
LYS A 642
 None
None
2TT  A1201 ( 4.6A)
None
2TT  A1201 ( 4.6A)
 1.45A 5kc0A-4oliA:
undetectable		 5kc0A-4oliA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 11 LEU A 903
GLY A 904
VAL A 911
ALA A 928
TYR A 980
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
 0.45A 5lvnA-4oliA:
26.0		 5lvnA-4oliA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 10 GLY A 904
VAL A 911
ALA A 928
ILE A 960
MET A 978
LEU A1030
 2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.4A)
 1.50A 5lw1E-4oliA:
19.9		 5lw1E-4oliA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 10 LEU A 903
VAL A 911
LYS A 930
GLU A 947
GLY A 984
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
2TT  A1202 (-3.4A)
 0.63A 5mo4A-4oliA:
23.0		 5mo4A-4oliA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 10 LEU A 903
VAL A 911
ALA A 928
TYR A 980
VAL A 981
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-3.7A)
2TT  A1202 (-4.4A)
 0.64A 5n3hA-4oliA:
23.9		 5n3hA-4oliA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 8 ALA A 928
GLU A 947
LEU A1030
ASP A1041
 2TT  A1202 ( 3.9A)
None
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.60A 5owrA-4oliA:
21.8		 5owrA-4oliA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		3 / 3 GLU A 688
TYR A 689
ARG A 638
 None
2TT  A1201 (-4.0A)
None
 0.80A 5uunA-4oliA:
undetectable		 5uunA-4oliA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 ALA A 928
GLU A 947
TYR A 980
GLY A 984
ASP A 988
ASP A1041
 2TT  A1202 ( 3.9A)
None
2TT  A1202 (-4.6A)
2TT  A1202 (-3.4A)
None
2TT  A1202 (-4.6A)
 0.79A 5vc3A-4oliA:
22.9		 5vc3A-4oliA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 LEU A 903
ALA A 928
GLU A 947
LEU A 976
GLY A 984
GLY A1040
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-3.4A)
 1.12A 5vcvA-4oliA:
23.4		 5vcvA-4oliA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 LEU A 903
ALA A 928
LYS A 930
GLU A 947
GLY A 984
GLY A1040
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-3.4A)
 1.06A 5vcvA-4oliA:
23.4		 5vcvA-4oliA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 ARG A 901
LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
 2TT  A1202 ( 4.8A)
2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.97A 5y7zA-4oliA:
21.6		 5y7zA-4oliA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 ARG A 901
LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
 2TT  A1202 ( 4.8A)
2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.97A 5y7zA-4oliA:
21.6		 5y7zA-4oliA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
ALA A 928
LYS A 930
GLU A 947
LEU A 976
GLY A 984
LEU A1030
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
None
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.74A 5y7zB-4oliA:
21.8		 5y7zB-4oliA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		8 / 12 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.72A 5y80A-4oliA:
6.3		 5y80A-4oliA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 LEU A 903
VAL A 911
ALA A 928
GLU A 947
TYR A 980
GLY A 984
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 (-4.6A)
2TT  A1202 (-3.4A)
 0.69A 5zv2A-4oliA:
27.6		 5zv2A-4oliA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		7 / 12 VAL A 911
ALA A 928
LYS A 930
GLU A 947
TYR A 980
GLY A 984
LEU A1030
 2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.61A 6bsdA-4oliA:
25.5		 6bsdA-4oliA:
8.72