SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2Q2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 8 TYR A  92
LEU A  95
SER A 174
GLU A  73
 None
None
None
2Q2  A 403 (-2.8A)
 1.08A 1i7zA-4o8mA:
undetectable		 1i7zA-4o8mA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		5 / 12 VAL A 196
SER A  68
ASN A  35
TYR A 147
ASN A 210
 None
None
None
2Q2  A 403 (-4.1A)
2Q2  A 403 (-2.8A)
 1.23A 3d4sA-4o8mA:
undetectable		 3d4sA-4o8mA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 8 ASN A 106
PRO A 211
SER A 237
GLY A 148
 None
None
2Q2  A 403 (-2.6A)
None
 0.92A 3lslA-4o8mA:
8.9
3lslD-4o8mA:
8.6		 3lslA-4o8mA:
19.88
3lslD-4o8mA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 6 ASP A  91
LEU A 176
HIS A 235
THR A 233
 2Q2  A 403 (-4.2A)
None
2Q2  A 403 (-3.9A)
None
 1.28A 4paeA-4o8mA:
undetectable		 4paeA-4o8mA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 4 ARG A 170
SER A 174
ASP A  91
HIS A 235
 2Q2  A 403 (-3.0A)
None
2Q2  A 403 (-4.2A)
2Q2  A 403 (-3.9A)
 1.27A 5zhmA-4o8mA:
undetectable		 5zhmA-4o8mA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Actinobacillus
succinogenes) 		4 / 6 LEU A  95
TYR A 147
GLN A  36
GLU A  73
 None
2Q2  A 403 (-4.1A)
None
2Q2  A 403 (-2.8A)
 1.50A 6djzC-4o8mA:
undetectable		 6djzC-4o8mA:
20.35