SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2PO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5o2j PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN PTXB
(Pseudomonas
stutzeri) 		5 / 12 TYR A  94
ALA A 159
ASP A 156
ILE A 251
TYR A  49
 2PO  A 301 (-4.9A)
None
None
None
2PO  A 301 (-4.7A)
 1.44A 1xvaB-5o2jA:
undetectable		 1xvaB-5o2jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		4 / 8 LEU A 185
SER A 132
VAL A 157
GLY A 158
 None
2PO  A 301 (-2.5A)
None
None
 0.93A 2qd5B-5jvbA:
3.8		 2qd5B-5jvbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		5 / 12 LEU A 185
TYR A  55
VAL A 157
GLY A 126
LEU A 177
 None
2PO  A 301 (-4.5A)
None
None
None
 1.27A 3pghA-5jvbA:
undetectable		 3pghA-5jvbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		5 / 12 GLY A 217
ASP A 182
PHE A 165
PHE A 180
HIS A 214
 None
2PO  A1002 (-4.3A)
None
None
None
 1.17A 4wh5A-2invA:
undetectable		 4wh5A-2invA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		6 / 12 LEU A 185
TYR A  55
VAL A 157
GLY A 126
SER A 133
LEU A 177
 None
2PO  A 301 (-4.5A)
None
None
2PO  A 301 ( 4.4A)
None
 1.29A 5jvzA-5jvbA:
undetectable		 5jvzA-5jvbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		5 / 12 LEU A 185
TYR A  55
GLY A 126
SER A 133
LEU A 177
 None
2PO  A 301 (-4.5A)
None
2PO  A 301 ( 4.4A)
None
 1.04A 5jvzB-5jvbA:
undetectable		 5jvzB-5jvbA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		4 / 7 GLY A 158
PHE A 156
SER A 133
ASP A 127
 None
None
2PO  A 301 ( 4.4A)
None
 1.00A 5n5dB-5jvbA:
2.4		 5n5dB-5jvbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 5o2j PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN PTXB
(Pseudomonas
stutzeri) 		4 / 7 GLY A 153
PHE A 151
SER A 127
ASP A 121
 None
None
2PO  A 301 ( 4.7A)
None
 1.11A 5n5dB-5o2jA:
2.6		 5n5dB-5o2jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN
(Trichodesmium
erythraeum) 		4 / 8 PRO A 137
THR A 131
TYR A 125
PRO A 180
 None
2PO  A 301 (-3.6A)
None
None
 1.21A 5x2sI-5jvbA:
undetectable
5x2sJ-5jvbA:
undetectable
5x2sK-5jvbA:
undetectable		 5x2sI-5jvbA:
19.86
5x2sJ-5jvbA:
23.48
5x2sK-5jvbA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5o2j PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN PTXB
(Pseudomonas
stutzeri) 		4 / 5 TYR A  94
GLN A 202
GLY A 255
ILE A 130
 2PO  A 301 (-4.9A)
None
None
None
 1.31A 6debB-5o2jA:
undetectable		 6debB-5o2jA:
20.00